2011 Fiscal Year Final Research Report
Advanced Molecular Transformations by Organ catalysts Based on Molecular Recognition
| Project/Area Number |
20245021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TERADA Masahiro 東北大学, 大学院・理学研究科, 教授 (50217428)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Itaru 東北大学, 大学院・理学研究科, 准教授 (00333899)
MOMIYAMA Norie 東北大学, 大学院・理学研究科, 助教 (80447127)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 触媒 / 分子変換 / 不斉合成 / 環境調和 / 水素結合 / 分子認識 / リン酸 / 不斉触媒 |
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| Research Abstract |
The activation of a substrate by means of a Bronsted acid and base is the most straightforward and common approach used to promote a reaction and hence Bronsted acids and bases have been widely utilized as efficient catalysts for a number of organic transformations. The development of novel Bronsted acid and base catalysts has been continuously studied due to their broad synthetic applicability. In the past decade, innovative research on Bronsted acid catalysis has enabled great progress. Specifically, research has focused on ' chiral Bronsted acid or base catalysis', in which enantioenriched products are obtained using a catalytic amount of a chiral organic molecule bearing an acidic or basic functionality. In our continuous studies on the cultivation of efficient and selective transformations using chiral Bronsted acids and bases, we successfully developed novel chiral Bronsted acids and several enantioselective transformations.
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