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2011 Fiscal Year Annual Research Report

サブナノ秒パルスパワー技術開発と環境・バイオ・リサイクル・微細加工・医療への応用

Research Project

Project/Area Number 20246053
Research InstitutionKumamoto University

Principal Investigator

秋山 秀典  熊本大学, 大学院・自然科学研究科, 教授 (50126827)

Co-Investigator(Kenkyū-buntansha) 勝木 淳  熊本大学, バイオエレクトリクス研究センター, 教授 (80233758)
浪平 隆男  熊本大学, バイオエレクトリクス研究センター, 准教授 (40315289)
佐久川 貴志  熊本大学, 大学院・自然科学研究科, 准教授 (40398186)
Keywords電気機器工学 / 電力工学 / プラズマ・核融合 / 環境
Research Abstract

パルス幅が数十ナノ秒の高繰り返しパルスパワー発生装置の開発と、環境浄化、バイオ技術、リサイクル、超微細加工などへの応用をこれまで行ってきた。本研究目的は、パルス幅を更に減少させて、サブナノ秒以下と極短パルスにした高繰り返しサブナノ秒パルスパワー発生装置の開発、サブナノ秒パルスパワーを高気圧気体、液体、超臨界流体及び固体に作用させて放電プラズマ生成、及び放電プラズマ或いはパルスパワーのバイオ・生体・化学物質等との相互作用を調べ、サブナノ秒パルスパワー応用としての新しい産業分野を形成する。さらに、パルスパワーのバイオへの作用とその環境・医療への応用という新しい分野であるバイオエレクトリクスの学問創生に寄与する。本年度は下記のような研究成果が得られた。1.パルスパワーの気体、液体、バイオ、超臨界への作用の解明を活かし、ディーゼル車や船からの排ガス処理(大気環境浄化として)、ダムのアオコ処理(湖沼環境浄化として)、排水の殺菌(水環境浄化として)、医療用殺菌(医療応用として)の四つに絞り、基礎研究を行った。いずれの応用も実用化の可能性があることが分かった。2.万能細胞と言われているES細胞に、サブナノ秒パルスパワーを印加して、細胞分化への影響を調べ、新しい作用因子となることを明らかにした。3.パルスパワーをヒラ細胞(人間の子宮がん細胞)に照射して、アポトーシスの誘導とその機構が明らかになってきたので、非加熱・無痛治療の可能性のある新しいがん治療法の開発を進めた。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

「パルスパワーを高気圧気体、液体、超臨界流体及び固体に作用させて放電プラズマを生成し、バイオ・生体・化学物質等との相互作用を調べ、パルスパワー応用としての新しい産業分野につなげる,さらに、パルスパワーのバイオへの作用とその環境・医療への応用という新しい分野であるバイオエレクトリクスの学問創生に寄与する。」という研究目的を順調に達成しつつある。

Strategy for Future Research Activity

次年度は最終年度であるので、これまでの基礎研究成果をもとに、車からの排ガス処理、アオコ処理、金属蒸着プラスチックのリサイクル、非侵襲型がん治療、iPS細胞生成手法等の実用化に向けて、データ集積を行う。

  • Research Products

    (62 results)

All 2012 2011

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (46 results)

  • [Journal Article] Enhancement of Proliferation Activity of Mammalian Cells by Intense Burst Sinusoidal Electric Fields2012

    • Author(s)
      M. Yano
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 19 Pages: 331-336

    • Peer Reviewed
  • [Journal Article] Effect of Pulsing Sequence of Nanosecond Pulsed Electric Fields on Viability of HeLa S3 Cells2012

    • Author(s)
      K. Mitsutake
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 19 Pages: 337-342

    • Peer Reviewed
  • [Journal Article] Energy Transfer Efficiency of Nano-Seconds Pulsed Power Generator for Nonthermal Plasma Processing Technique2011

    • Author(s)
      D.Wang, 他
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 18 Pages: 1091-1096

    • Peer Reviewed
  • [Journal Article] Influence of 60 ns Pulsed Electric Fields on Embryonic Stem Cells2011

    • Author(s)
      M.akiyama, 他
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 18 Pages: 1119-1123

    • Peer Reviewed
  • [Journal Article] ANew Family of Marx Generators Based on Commutation Circuits2011

    • Author(s)
      S.Zabihi, 他
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 18 Pages: 1181-1188

    • Peer Reviewed
  • [Journal Article] Nanosecond Pulsed Power Application to Nitrogen Oxides Treatment with Coaxial Reactors2011

    • Author(s)
      N.Shimomura, 他
    • Journal Title

      IEEE Transactions on Dielectrics and Electrical Insulation

      Volume: 18 Pages: 1274-1280

    • Peer Reviewed
  • [Journal Article] Weibull Statistical Analysis of Pulsed Breakdown Voltages in High-Pressure Carbon Dioxide Including Supercritical Phase2011

    • Author(s)
      T.Kiyan, 他
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 39 Pages: 1729-1735

    • Peer Reviewed
  • [Journal Article] Electrical Recovery After Laser-Assisted Discharge for Highly Repetitive Plasma EUV Source2011

    • Author(s)
      P.Lu, 他
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 39 Pages: 1849-1854

    • Peer Reviewed
  • [Journal Article] Optical observation of cell sonoporation with low intensity ultrasound2011

    • Author(s)
      Seyedeh Moosavi Nejad, 他
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 413 Pages: 218-223

    • Peer Reviewed
  • [Journal Article] Propagation of Streamer Heads During a 5-ns Pulsed Discharge2011

    • Author(s)
      D.Wnag, 他
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 39 Pages: 2268-2269

    • Peer Reviewed
  • [Journal Article] Discharge Appearances of 2-and 5-ns Pulsed Power2011

    • Author(s)
      T.Matsumoto, 他
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 39 Pages: 2262-2263

    • Peer Reviewed
  • [Journal Article] Streamer Propagation of Nanosecond Pulse Discharge With Various Rise Times2011

    • Author(s)
      I.Yagi, 他
    • Journal Title

      IEEE Transactions on Plasma Science

      Volume: 39 Pages: 2232-2233

    • Peer Reviewed
  • [Journal Article] パルス高電界の生体作用と先端的医療応用2011

    • Author(s)
      勝木淳, 他
    • Journal Title

      プラズマ・核融合学会誌

      Volume: 87 Pages: 710-714

    • Peer Reviewed
  • [Journal Article] FPGAを用いたパルスパワーの電圧制御2011

    • Author(s)
      秋山雅裕, 他
    • Journal Title

      プラズマ・核融合学会誌

      Volume: 87 Pages: 724-727

    • Peer Reviewed
  • [Journal Article] Degradation of Aniline by Pulsed Discharge Plasma in Hydrothermal Conditions2011

    • Author(s)
      Wahyudiono, 他
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 36 Pages: 459-464

    • Peer Reviewed
  • [Journal Article] Characteristics of Micro Underwater Shock Waves Produced by Pulsed Electric Discharges for Medical Applications2011

    • Author(s)
      S.H.R.Hosseini, 他
    • Journal Title

      Journal of the Korean Physical Society

      Volume: 59 Pages: 3526-3530

    • Peer Reviewed
  • [Presentation] 磁気スイッチによるオゾナイザの放電安定性の向上2012

    • Author(s)
      田中文章
    • Organizer
      電気学会全国大会
    • Place of Presentation
      広島工業大学(広島)
    • Year and Date
      2012-03-22
  • [Presentation] パルスパワー方式マイクロプラズマの生成2012

    • Author(s)
      猪口誠
    • Organizer
      電気学会全国大会
    • Place of Presentation
      広島工業大学(広島)
    • Year and Date
      2012-03-21
  • [Presentation] 高繰り返しパルスパワー発生用スイッチング周波数1MHz充電器2012

    • Author(s)
      梶原泰治
    • Organizer
      電気学会全国大会
    • Place of Presentation
      広島工業大学(広島)
    • Year and Date
      2012-03-21
  • [Presentation] 超臨界二酸化炭素中における正ストリーマ形状の複雑性評価2011

    • Author(s)
      古里友宏
    • Organizer
      放電学会年次大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-11-26
  • [Presentation] バイオエレクトリクス:プラズマの生体相互作用2011

    • Author(s)
      秋山秀典
    • Organizer
      Plasma Conference 2011
    • Place of Presentation
      右川県立音楽堂(石川)
    • Year and Date
      2011-11-23
  • [Presentation] Applications of nano-seconds pulsed discharge2011

    • Author(s)
      浪平隆男
    • Organizer
      2nd ISNPEDADM-2011
    • Place of Presentation
      New Calednia
    • Year and Date
      2011-11-16
  • [Presentation] Environmental Application of Nano-Seconds Pulsed Discharge System2011

    • Author(s)
      浪平隆男
    • Organizer
      The17th International Conference on Advanced Oxidation Technologies for Treatment of Water, Air and Soil
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-11-08
  • [Presentation] Degradation of Phenol by Nano-Seconds Pulsed Discharge on Solution Surface2011

    • Author(s)
      島崎祐輔
    • Organizer
      The17th International Conference on Advanced Oxidation Technologies for Treatment of Water, Air and Soil
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-11-08
  • [Presentation] Phenol Treatment by Laser Produced Plasma in Pressurized Solution2011

    • Author(s)
      鶴我諒介
    • Organizer
      The17th International Conference on Advanced Oxidation Technologies for Treatment of Water, Air and Soil
    • Place of Presentation
      San Diego USA
    • Year and Date
      2011-11-08
  • [Presentation] Underwater shock waves, cavitation and their medicalical applications2011

    • Author(s)
      HOSSEINI SEYED HAMID REZA
    • Organizer
      第20回日本ソノケミストリー学会討論会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2011-11-04
  • [Presentation] パルス高電界の生体作用と最新技術2011

    • Author(s)
      勝木淳
    • Organizer
      第11回マイナスイオン応用フォーラム
    • Place of Presentation
      東京大学(東京都)(招待講演)
    • Year and Date
      2011-10-14
  • [Presentation] 高繰り返しパルスパワー発生用共振充電器の開発2011

    • Author(s)
      松本勇人
    • Organizer
      平成23年電気学会基礎・材料・共通部門大会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-09-21
  • [Presentation] パルスパワー水中放電を利用したアオコ処理2011

    • Author(s)
      青木伸親
    • Organizer
      平成23年電気学会基礎・材料・共通部門大会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-09-21
  • [Presentation] パルス高電界を用いた細胞への熱的、非熱的効果2011

    • Author(s)
      光武和典
    • Organizer
      平成23年電気学会基礎・材料・共通部門大会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-09-21
  • [Presentation] 大気圧プラズマジェットによる細胞内へのタンパク質導入2011

    • Author(s)
      高村紀充
    • Organizer
      平成23年電気学会基礎・材料・共通部門大会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-09-21
  • [Presentation] パルスパワーによるウミグモの電気的駆除2011

    • Author(s)
      後藤貴弘
    • Organizer
      平成23年電気学会基礎・材料・共通部門大会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-09-21
  • [Presentation] Influence of Pulse Rise Time on Streamer Velocity and Spectroscopic of Plasma Emission Using All Solid Type Nanosecond Pulsed Power Generator2011

    • Author(s)
      浪平隆男
    • Organizer
      静電気学会全国大会
    • Place of Presentation
      東京理科大学(東京都)
    • Year and Date
      2011-09-12
  • [Presentation] Development of a, Rapid e-Learning System and its Use at Graduate School2011

    • Author(s)
      秋山秀典
    • Organizer
      ITHET2011
    • Place of Presentation
      Kusadasi TURKIYE(招待講演)
    • Year and Date
      2011-08-05
  • [Presentation] High repetitive pulsed streamer discharges in water, their induced shock waves and medical applications2011

    • Author(s)
      HOSSEINI SEYED HAMID REZA
    • Organizer
      The 28th International Symposium on Shock Waves
    • Place of Presentation
      Manchester UK
    • Year and Date
      2011-07-19
  • [Presentation] Visualization of Positive Pulsed Streamer in Supercirtical Carbon Dioxide by Schlieren Method2011

    • Author(s)
      喜屋武毅
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Influence of Gas Flow Rate and Pressure in Reactor on Ozone Production Using a Compact Pulsed Power Generator2011

    • Author(s)
      田中文章
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Pulsed Pre-breakdown Phenomena in High Pressurized Carbon Dioxide including Supercritical State2011

    • Author(s)
      猪原武士
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Single Nanosecond Pulsed Power Induced Structural Modifications of Medaka Fish Embryo2011

    • Author(s)
      姜東求
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Simulation of Burst Electromagnetic Waves Inside a Human Body for Medical Applications2011

    • Author(s)
      石澤栄俊
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Visualization and Analysis of Underwater Shock Wave Focusing Generated by Magnetic Pulse Compression(MPC)2011

    • Author(s)
      尾下大樹
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] A Repetitive Solid State Marx-Type Pulsed Power Generator Using Multi-Stage Switch-Capacitor Cells2011

    • Author(s)
      坂本達朗
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Visualization of Positive Pulsed Streamer in Supercritical Carbon Dioxide by Schlieren Method2011

    • Author(s)
      古里友宏
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Miniature Pulsed Power Generator Using a Magnetic Pulse Compression Circuit2011

    • Author(s)
      伊藤優太
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Focusing System of Burst Electromagnetic Waves for Medical Applications2011

    • Author(s)
      橋本成功
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Effects of Pulsed Electric Field Number on Embryonic Development of Oryzias Latipes2011

    • Author(s)
      山中雅斗
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Compact Capacitor Charger Using Resonant MOSFET Inverter2011

    • Author(s)
      佐久川貴志
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Characteristics of High Voltage Electrical Discharge Induced Non-Thermal Plasma in Aqueous Solution under Pulsed Control2011

    • Author(s)
      青木伸親
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Production of Uniform Underwater Shock Waves by Pulsed Electric Discharge2011

    • Author(s)
      奥田裕太
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Stimulation of HeLa Cells by Intense Pulsed Ultraviolet Radiation from Z-Pinch Plasma2011

    • Author(s)
      呂鵬
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Response of HeLa Cells to Transient Thermal Shock2011

    • Author(s)
      光武和典
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Enhancement of Yeast Proliferation Using Pulsed Atmospheric Discharge Plasmas2011

    • Author(s)
      竹内翔
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Study of Proliferation of Budding Yeast Subjected to Nanosecond Pulsed Electric Fields2011

    • Author(s)
      山野孝行
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Gene Analysis of HeLa Cells Subjected to Intense Burst Sinusoidal Electrie Fields2011

    • Author(s)
      田中展子
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Gene Expression Analysis of Apoptosis Pathway in HeLa S3 Cells Subjected to Nanosecond Pulsed Electric Fields2011

    • Author(s)
      矢野美沙子
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Gas temperature measurements of nano-seconds pulsed discharge based ozonizer2011

    • Author(s)
      松本宇生
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Ozone Generation Using Positive- and Negative-Nano-Seconds Pulsed Discharges2011

    • Author(s)
      高村紀充
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Toluene Decomposition Using Nano-Seconds Pulsed Discharge2011

    • Author(s)
      荒木良考
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Axial Propagation of Nano-Seconds Pulsed Discharge in Coaxial Reactor2011

    • Author(s)
      廣田智行
    • Organizer
      18th International Pulsed Power Conference
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-06-23
  • [Presentation] Effect of Field-Induced Transient Thermal Shock on HeLa Cells2011

    • Author(s)
      光武和典
    • Organizer
      2011 International Bioelectrics Symposium
    • Place of Presentation
      Toulouse FRANCE
    • Year and Date
      2011-05-06
  • [Presentation] Analysis of Ion Influx and Expression of CERAMIDE in Hela S3 Cells Subjected to Nanosecond Pulsed Electric Fields2011

    • Author(s)
      秋山秀典
    • Organizer
      2011 International Bioelectrics Symposium
    • Place of Presentation
      Toulouse FRANCE(招待講演)
    • Year and Date
      2011-05-05
  • [Presentation] Nanosecond electric pulse generated underwater shock waves for noninvasive therapies2011

    • Author(s)
      HOSSEINI SEYED HAMID REZA
    • Organizer
      2011 International Bioelectrics Symposium
    • Place of Presentation
      Toulouse FRANCE
    • Year and Date
      2011-05-05

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Published: 2013-06-26  

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