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2013 Fiscal Year Final Research Report

Multidisciplinary studies on the biological functions of GnRH peptidergic neurons

Research Project

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Project/Area Number 20247005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

OKA Yoshitaka  東京大学, 理学(系)研究科(研究院), 教授 (70143360)

Co-Investigator(Renkei-kenkyūsha) AKAZOME Yasuhisa  東京大学, 大学院理学系研究科, 助教 (50302807)
KANDA Shinji  東京大学, 大学院理学系研究科, 助教 (50634284)
Project Period (FY) 2008-04-08 – 2013-03-31
Keywordsペプチド / 生殖 / 性行動 / 神経生理学 / トランスジェニック / メダカ
Research Abstract

We generated GnRH1, GnRH2, and GnRH3 GFP-transgenic medaka to visualize each neuron in a whole brain in vitro preparation. We recorded spontaneous electrical activities and responses to various neurotransmitter/neuromodulator substances and analyzed their physiological functions. We also generated a transgenic medaka for monitoring the release activity of pituitary gonadotropic hormones and analyzed the central mechanisms of hormone release. Our research achievements enabled us to understand the multiple biological functions of GnRH peptidergic neurons that are based on their evolutionary history.

  • Research Products

    (69 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (39 results) (of which Peer Reviewed: 39 results) Presentation (28 results) (of which Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Neurobiological study of fish brains gives insights into the nature of gonadotropin-releasing hormone 1-3 neurons2013

    • Author(s)
      Karigo, T., and Oka, Y.
    • Journal Title

      Frontiers in Endocrinology (Experimental Endocrinology). "Biology of Gonadotropin-Releasing Hormone Neurons"

      Volume: 4:177(Article 177) Pages: 1-10

    • DOI

      10.3389/fendo.2013.00177

    • Peer Reviewed
  • [Journal Article] Anatomical distribution of sex steroid hormone receptors in the brain of female medaka2013

    • Author(s)
      Zempo, B., Kanda, S., Okubo, K., Akazome, Y., and Oka, Y.
    • Journal Title

      Journal of Comparative Neurology

      Volume: 521 Pages: 1760-1780

    • DOI

      10.1002/cne.23255

    • Peer Reviewed
  • [Journal Article] Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons2013

    • Author(s)
      Umatani, C., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 109 Pages: 2354-2363

    • DOI

      10.1152/jn.00145.2012

    • Peer Reviewed
  • [Journal Article] Neuroanatomical evidence that kisspeptin directly regulates isotocin and vasotocin neurons2013

    • Author(s)
      Kanda, S., Akazome, Y., Mitani, Y., Okubo, K., and Oka, Y.
    • Journal Title

      PLosOne

      Volume: 8 Pages: e62776

    • DOI

      10.1371/journal.pone.0062776

    • Peer Reviewed
  • [Journal Article] Expression and putative function of kisspeptins and their receptors during early development in medaka2013

    • Author(s)
      Hodne, K., Weltzien, F.-A., Oka, Y., and Okubo, K.
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 3437-3446

    • DOI

      10.1210/en.2013-1065

    • Peer Reviewed
  • [Journal Article] Burst generation mediated by cholinergic input in terminal nerve-gonadotrophin releasing hormone neurones of the goldfish2013

    • Author(s)
      Kawai, T., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Physiology-London

      Volume: 591 Pages: 5509-5523

    • DOI

      10.1113/jphysiol.2013.258343

    • Peer Reviewed
  • [Journal Article] Evolutionary insights into the steroid sensitive kiss1 and kiss2 neurons in the vertebrate brain2012

    • Author(s)
      Kanda, S., and Oka, Y.
    • Journal Title

      Frontiers in Genomic Endocrinology "Estrogenic control of hypothalamic GnRH neurons"

      Volume: 3:28(Article 28) Pages: 1-10

    • DOI

      10.3389/fendo.2012.00028

    • Peer Reviewed
  • [Journal Article] Dopaminergic neuromodulation of synaptic transmission between the mitral and granule cells in the teleost olfactory bulb2012

    • Author(s)
      Kawai, T., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 107 Pages: 1313-1324

    • DOI

      10.1152/jn.00536.2011

    • Peer Reviewed
  • [Journal Article] Steroid sensitive kiss2 neurones in the goldfish: evolutionary insights into the duplicate kisspeptin gene-expressing neurones2012

    • Author(s)
      Kanda, S., Karigo, T., and Oka, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 24 Pages: 897-906

    • DOI

      10.1111/j.1365-2826.2012.02296.x

    • Peer Reviewed
  • [Journal Article] Time-of-day dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka2012

    • Author(s)
      Karigo, T., Kanda, S., Abe, H., Okubo, K., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 3394-3404

    • DOI

      10.1210/en.2011-2022

    • Peer Reviewed
  • [Journal Article] Female-specific target sites for both estrogen and androgen in the teleost brain2012

    • Author(s)
      Hiraki, T., Takeuchi, A., Tsumaki, T., Zempo, B., Kanda, S., Oka, Y., Nagahama, Y., and Okubo, K.
    • Journal Title

      Proceedings of the Royal Society. B, Biological sciences

      Volume: 279 Pages: 5014-5023

    • DOI

      10.1098/rspb.2012.2011

    • Peer Reviewed
  • [Journal Article] Mechanisms of neuromodulation by a nonhypophysiotropic GnRH system controlling motivation for reproductive behavior in the teleost brain2011

    • Author(s)
      Abe, H., and Oka, Y.
    • Journal Title

      Journal of Reproduction and Development

      Volume: 57 Pages: 665-674

    • Peer Reviewed
  • [Journal Article] Sex differences in aromatase gene expression in the medaka brain2011

    • Author(s)
      Okubo, K., Takeuchi, A., Chaube, R., Paul-Prasanth, B., Kanda, S., Oka, Y., and Nagahama, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 23 Pages: 412-423

    • DOI

      10.1111/j.1365-2826.2011.02120.x

    • Peer Reviewed
  • [Journal Article] Expression of vesicular glutamate transporter-2.1 in medaka terminal nerve gonadotrophinreleasing hormone neurones2011

    • Author(s)
      Akazome, Y., Kanda, S., and Oka, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 23 Pages: 570-576

    • DOI

      10.1111/j.1365-2826.2011.02142.x

    • Peer Reviewed
  • [Journal Article] Differential regulation of luteinizing hormone genes in teleosts and tetrapods due to their distinct genomic environments-insights into gonadotropin beta subunit evolution2011

    • Author(s)
      Kanda, S., Okubo, K., and Oka, Y.
    • Journal Title

      General and Comparative Endocrinology

      Volume: 173 Pages: 253–258

    • DOI

      10.1016/j.ygcen.2011.05.015

    • Peer Reviewed
  • [Journal Article] Anatomical relations between neuropeptide Y, galanin, and gonadotropin-releasing hormone in the brain of chondrostean, the Siberian sturgeon Acipenser baeri2011

    • Author(s)
      Amiya, N., Amano, M., Tabuchi, A., and Oka, Y.
    • Journal Title

      Neuroscience Letters

      Volume: 503 Pages: 87-92

    • DOI

      10.1016/j.neulet.2011.08.008

    • Peer Reviewed
  • [Journal Article] Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of the male and female red seabream Pagrus major2011

    • Author(s)
      Shimizu, Y., Tomikawa, J., Hirano, K., Nanikawa, Y., Akazome, Y., Kanda, S., Kazeto, Y., Okuzawa, K., Uenoyama, Y., Ohkura, S., Tsukamura, H., Maeda, K.-I., Gen, K., Oka, Y., and Yamamoto, N.
    • Journal Title

      General and Comparative Endocrinology

      Volume: 175 Pages: 432-442

    • DOI

      10.1016/j.ygcen.2011.11.038

    • Peer Reviewed
  • [Journal Article] Functional and evolutionary insights into vertebrate kisspeptin systems from studies of fish brain2010

    • Author(s)
      Akazome, Y., Kanda, S., Okubo, K., and Oka, Y.
    • Journal Title

      Special Issue of the Journal of Fish Biology; Reproductive Physiology STATE-OF-THE-SCIENCE, Journal of Fish Biology

      Volume: 76 Pages: 161-182

    • DOI

      10.1111/j.1095-8649.2009.02496.x

    • Peer Reviewed
  • [Journal Article] Electrophysiological characteristics of gonadotrophinreleasing hormone 1-3 neurones: insights from a study of fish brains2010

    • Author(s)
      Oka, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 22 Pages: 659-663

    • DOI

      10.1111/j.1365-2826.2010.02035.x

    • Peer Reviewed
  • [Journal Article] Transgenic medaka in neurobiological studies (In Japanese)2010

    • Author(s)
      Kanda, S., and Oka, Y.
    • Journal Title

      Laboratory Animal Technology and Science

      Volume: 22(5) Pages: 16-22

    • Peer Reviewed
  • [Journal Article] Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus2010

    • Author(s)
      Maeda, K.-I., Ohkura, S., Uenoyama, Y., Wakabayashi, Y., Oka, Y., Tsukamura, H., and Okamura, H.
    • Journal Title

      Brain Research 1364 (Review, Special Issue: New Insights into the Neurobiology of Reproduction and Puberty)

      Pages: 103-115

    • DOI

      10.1016/j.brainres.2010.10.026

    • Peer Reviewed
  • [Journal Article] Regular pacemaker activity characterizes gonadotropinreleasing hormone 2 neurons recorded from green fluorescent protein-transgenic medaka2010

    • Author(s)
      Kanda, S., Nishikawa, K., Karigo, T., Okubo, K., Isomae, S, Abe, H., Kobayashi, D., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 695-701

    • DOI

      10.1210/en.2009-0842

    • Peer Reviewed
  • [Journal Article] Hypothalamic kiss1 but not kiss2 neurons are involved in estrogen feedback in medaka (Oryzias latipes)2010

    • Author(s)
      Mitani, Y., Kanda, S., Akazome, Y., Zempo, B., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 1751–1759

    • DOI

      10.1210/en.2009-1174

    • Peer Reviewed
  • [Journal Article] Excitatory action of GABA in the terminal nerve gonadotropinreleasing hormone neurons2010

    • Author(s)
      Nakane, R., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 103 Pages: 1375-1384

    • DOI

      10.1152/jn.00910.2009

    • Peer Reviewed
  • [Journal Article] Biochemical and immunohistochemical analyses of a GnRH-like peptide in the neural ganglia of the Pacific abalone Haliotis discus hannai (Gastropoda)2010

    • Author(s)
      Amano, M., Moriyama, S., Okubo, K., Nagai, Y., Amiya, N., Takahashi, A., and Oka, Y.
    • Journal Title

      Zoological Science

      Volume: 27 Pages: 656–661

    • DOI

      10.2108/zsj.27.656

    • Peer Reviewed
  • [Journal Article] Biochemical and immunohistochemical analyses of GnRH like peptides in the nerve ganglion of the chiton2010

    • Author(s)
      Amano, M., Yokoyama, T., Amiya, N., Hotta, M., Takakusaki, Y., Kado, R., and Oka, Y.
    • Journal Title

      Acanthopleura japonica. Zoological Science

      Volume: 27 Pages: 924-930

    • DOI

      10.2108/zsj.27.924

    • Peer Reviewed
  • [Journal Article] Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons2010

    • Author(s)
      Saito, T., Nakane, R., Akazome, Y., Abe, H., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 104 Pages: 3518-3529

    • DOI

      10.1152/jn.01027.2009

    • Peer Reviewed
  • [Journal Article] Neuromodulatory effect of GnRH on the synaptic transmission of the olfactory bulbar neural circuit in goldfish, Carassius auratus2010

    • Author(s)
      Kawai, T., Abe, H., Akazome, Y., and Oka, Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 104 Pages: 3540-3550

    • DOI

      10.1152/jn.00639.2010

    • Peer Reviewed
  • [Journal Article] Three types of gonadotrophin-releasing hormone neurones and steroid-sensitive sexually dimorphic kisspeptin neurones in teleosts2009

    • Author(s)
      Oka, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 21 Pages: 334-338

    • DOI

      10.1111/j.1365-2826.2009.01850.x

    • Peer Reviewed
  • [Journal Article] The role of the terminal nerve and GnRH in olfactory system neuromodulation2009

    • Author(s)
      Kawai, T., Oka, Y., and Eisthen, H.
    • Journal Title

      Zoological Science

      Volume: 26 Pages: 669-680

    • DOI

      10.2108/zsj.26.669

    • Peer Reviewed
  • [Journal Article] Primary culture of the isolated terminal nerve-gonadotrophin releasing hormone (GnRH) neurones derived from adult teleost (dwarf gourami, Colisa lalia) brain for the study of peptide release mechanisms2009

    • Author(s)
      Abe, H., and Oka, Y.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 21 Pages: 489-505

    • DOI

      10.1111/j.1365-2826.2009.01866.x

    • Peer Reviewed
  • [Journal Article] Possible role of oestrogen in pubertal increase of Kiss1/Kisspeptin expression in discrete hypothalamic areas of female rats2009

    • Author(s)
      Takase, K., Uenoyama, Y., Inoue, N., Matsui, H., Yamada, S., Shimizu, M., Homma,T., Tomikawa, J., Kanda, S., Matsumoto, H., Oka, Y., Tsukamura, H., and Maeda, K.-I.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 21 Pages: 527–537

    • DOI

      10.1111/j.1365-2826.2009.01868.x

    • Peer Reviewed
  • [Journal Article] Interaction between neuropeptide Y immunoreactive neurons and galanin immunoreactive neurons in the brain of the masu salmon, Oncorhynchus masou2009

    • Author(s)
      Amano, M., Amiya, N., Hiramatsu, M., Tomioka, T., and Oka, Y.
    • Journal Title

      Neuroscience Letters

      Volume: 462 Pages: 33-38

    • DOI

      10.1016/j.neulet.2009.06.067

    • Peer Reviewed
  • [Journal Article] Calcium oscillations in the olfactory nonsensory cells of the goldfish, Carassius auratus2009

    • Author(s)
      Kawai, T., Abe, H., Wakabayashi, K., and Oka, Y.
    • Journal Title

      Biochimica et Biophysica Acta-General Subjects

      Volume: 1790 Pages: 1681-1688

    • DOI

      10.1016/j.bbagen.2009.09.009

    • Peer Reviewed
  • [Journal Article] Biochemical analysis and immunohistochemical examination of a GnRH-like immunoreactive peptide in the central nervous system of a decapod crustacean the kuruma prawn (Marsupenaeus japonicus)2009

    • Author(s)
      Amano, M., Okumura, T., Okubo , K., Amiya, N., Takahashi, A, and Oka, Y.
    • Journal Title

      Zoological Science, Zoological Science Award. 2010

      Volume: 26 Pages: 840-845

    • DOI

      10.2108/zsj.26.840

    • Peer Reviewed
  • [Journal Article] Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually-dimorphic kisspeptin neurons in medaka (Oryzias latipes)2008

    • Author(s)
      Kanda, S., Akazome, Y., Matsunaga, T., Yamamoto, N., Yamada, S., Tsukamura, H., Maeda, K., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 149 Pages: 2467-2476

    • DOI

      10.1210/en.2007-1503

    • Peer Reviewed
  • [Journal Article] Coordinated synchronization in the electrically coupled network of terminal nerve gonadotropinreleasing hormone neurons as demonstrated by double patch-clamp study2008

    • Author(s)
      Haneda, K., and Oka, Y.
    • Journal Title

      Endocrinology

      Volume: 149 Pages: 3540-3548

    • DOI

      10.1210/en.2008-0299

    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of a GnRH-like peptide in the brain of the cephalopod spear-squid, Loligo bleekeri2008

    • Author(s)
      Amano, M., Oka, Y., Nagai, Y., Amiya, N., and Yamamori, K.
    • Journal Title

      General and Comparative Endocrinol.

      Volume: 156 Pages: 277-284

    • DOI

      10.1016/j.ygcen.2008.01.008

    • Peer Reviewed
  • [Journal Article] Identification and expression analysis of peroxisome proliferatoractivated receptors cDNA in a reptile, the leopard gecko (Eublepharis macularius)2008

    • Author(s)
      Kato, K., Oka, Y., and Park, M.K.
    • Journal Title

      Zoological Science

      Volume: 25 Pages: 492-502

    • DOI

      10.2108/zsj.25.492

    • Peer Reviewed
  • [Presentation] Morphological analysis of the early development of GnRH neuron systems in the EGFP-expressing transgenic medaka lines2013

    • Author(s)
      Takahashi, A., Islam, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      20131109-13
  • [Presentation] Neurobiological analysis of dopaminergic inhibition in the HPG axis regulation2013

    • Author(s)
      Karigo, T., Oka, Y.
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience 2013
    • Place of Presentation
      San Diego
    • Year and Date
      20131109-13
  • [Presentation] 生殖の中枢制御に関わるペプチドニューロン系の研究2013

    • Author(s)
      岡良隆
    • Organizer
      日本動物学会第84回大会, 平成25年度日本動物学会賞受賞者講演
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] 生殖・性行動調節にかかわる脳部位における性差2013

    • Author(s)
      岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] 終神経GnRHニューロンが視覚神経回路に及ぼす作用の解析2013

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] メダカの配偶者選択の分子神経基盤2013

    • Author(s)
      奥山輝大、横井佐織、阿部秀樹、磯江泰子、末廣勇司、今田はるか、島田敦子、川崎隆史、弓場俊輔、谷口善仁、亀井保博、田中実、成瀬清、武田洋幸、岡良隆、久保健雄、竹内秀明
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] RFRP ニューロンの自発活動とGnRH1ニューロン発火抑制に関する電気生理学的解析2013

    • Author(s)
      貝瀬峻、神田真司、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] 性ステロイド感受性を示すKiss1 ニューロンの電気生理学的解析2013

    • Author(s)
      長谷部政治、神田真司、島田洋之、岡良隆
    • Organizer
      日本動物学会第84回大会
    • Place of Presentation
      岡山
    • Year and Date
      20130926-28
  • [Presentation] GnRH neurons involved in central regulation of reproduction and reproductive behavior2013

    • Author(s)
      Oka, Y.
    • Organizer
      2013 Gordon Research Conference, Neuroethology: Behavior, Evolution & Neurobiology; Networks, Circuits, and Modules
    • Place of Presentation
      Mount Snow Resort, West Dover, VT, USA
    • Year and Date
      20130817-25
    • Invited
  • [Presentation] 生殖の中枢制御の鍵を握るキスペプチンとその受容体GPR54を発現するニューロンへの新たな生理学的アプローチ2013

    • Author(s)
      岡良隆
    • Organizer
      第10回GPCR 研究会
    • Place of Presentation
      東京
    • Year and Date
      20130510-11
    • Invited
  • [Presentation] Functional and evolutionary diversity of vertebrate kisspeptin neuron systems 脊椎動物キスペプチン神経系の進化と多様な機能2013

    • Author(s)
      Kanda, S. and Oka, Y.
    • Organizer
      Hiroshi and Aya Irisawa Memorial Award Symposium, The 90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      20130327-29
    • Invited
  • [Presentation] 脊椎動物キスペプチン神経系の進化と未知の機能2013

    • Author(s)
      神田真司、岡良隆
    • Organizer
      東京大学大気海洋研究所共同利用研究集会
    • Place of Presentation
      柏
    • Year and Date
      2013-06-22
    • Invited
  • [Presentation] gpr54-1-EGFP Transgenic Medaka - a New Approach towards the Understanding of Novel Functions of Kisspeptin Neurons2012

    • Author(s)
      Kanda, S., Nakajo, M., Lee, J., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
    • Invited
  • [Presentation] Embryonic Expression and Function of Kisspeptins and their Receptors in a Teleost Fish, medaka2012

    • Author(s)
      Okubo, K., Hodne, K., Kanda, S., Shimada, H., Oka, Y., Weltzien, F.A.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Electrophysiological and Morphological Analysis of Kiss1 Neurons in Trasgenic Medaka, Oryzias latipes2012

    • Author(s)
      Shimada, H., Kanda, S., Akazome, Y., Abe, H., Okubo, K., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Effects of Kisspeptins on LH Secretion and GnRH1 Neuronal Activities in Goldfish and Medaka2012

    • Author(s)
      Karigo, T., Uenoyama, Y., Oishi, S., Fujii, N., Mitani, Y., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Generation of kiss1 Knockout Medaka using Efficient New Genetic Tools, TALENs2012

    • Author(s)
      Takahashi, A., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Steroid Sensitive Hypothalamic Kiss1 Neurons in Medaka do not Co-express NKB or DYN2012

    • Author(s)
      Zempo, B., Kanda, S., Akazome, Y., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Kiss2 may Activate Receptors for Neuropeptide FF (NPFF) / RF Amide Related Peptide (RFRP) in Medaka2012

    • Author(s)
      Akazome, Y., Yamamoto, E., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Inhibitory Regulation of GnRH3 Neurons by RFRP Neurons in Medaka2012

    • Author(s)
      Nakane, R., Kanda, S., Oka, Y.
    • Organizer
      The 2nd World Conference on Kisspeptin Signaling in the Brain
    • Place of Presentation
      Tokyo
    • Year and Date
      20121106-09
  • [Presentation] Neuroanatomical evidence for direct kisspeptin regulation of vasotocin and isotocin neurons2012

    • Author(s)
      S. Kanda, Y. Oka
    • Organizer
      The 42th Annual Meeting of the Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      20121013-17
  • [Presentation] Neuropeptide RFRP inhibits the pacemaker activity of extrahypothalamic GnRH neurons2012

    • Author(s)
      C. Umatani, H. Abe, Y. Oka
    • Organizer
      The 42th Annual Meeting of the Society for Neuroscience 2012
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      20121013-17
  • [Presentation] RFRPによる終神経GnRHニューロン発火活動抑制作用の解析2012

    • Author(s)
      馬谷千恵、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] 終神経GnRHニューロンにおけるコリン作動性入力を介したバースト活動の誘起2012

    • Author(s)
      河合喬文、阿部秀樹、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] 終神経GnRHペプチドニューロン細胞塊におけるGnRHニューロン間結合様式2012

    • Author(s)
      阿部秀樹、西川穂高、末次翔太、岡良隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20120918-21
  • [Presentation] 生殖中枢制御に対するドーパミンを介した抑制作用に関する神経生物学的解析2012

    • Author(s)
      苅郷友美、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Year and Date
      20120913-15
  • [Presentation] 絶食によるメダカ視床下部NPYニューロンのNPYmRNA発現変動2012

    • Author(s)
      北原翔一、神田真司、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Year and Date
      20120913-15
  • [Presentation] キスペプチン受容体発現ニューロンのGFP標識による未知のキスペプチン機能の探索2012

    • Author(s)
      神田真司、李惇馥、岡良隆
    • Organizer
      日本動物学会第83回大会
    • Place of Presentation
      大阪
    • Year and Date
      20120913-15
  • [Book] Structure, synthesis, and phylogeny of kisspeptin and its receptor. In: " Kisspeptin Signaling in Reproductive Biology " (ed. by A. Kauffman and J. Smith), Chapter 2, Adv Exp Med Biol.2013

    • Author(s)
      Kanda, S., and Oka, Y.
    • Total Pages
      784:9-26
    • Publisher
      Springer Verlag, New York(doi:10.1007/978-1-4614-6199-9_2 査読有)
    • DOI

      10.1007/978-1-4614-6199-9_2

  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/naibunpi/lab.html

URL: 

Published: 2015-07-16   Modified: 2023-03-16  

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