2010 Fiscal Year Final Research Report
Pheromone-responsive reorganization of chromosomes in meiosis
| Project/Area Number |
20247021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
HIRAOKA Yasushi Osaka University, 大学院・生命機能研究科, 教授 (10359078)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAKAWA Haruhiko 大阪大学, 生命機能研究科, 助教 (70399533)
CHIKASHIGE Yuji (独)情報通信研究機構, 未来ICT研究センターバイオICTグループ, 主任研究員 (60359081)
DING Da-Qiao (独)情報通信研究機構, 未来ICT研究センターバイオICTグループ, 主任研究員 (50359080)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 染色体 / ゲノム / 可視化 / 細胞・組織 / 染色体構築・機能・分配 / 減数分裂 |
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| Research Abstract |
We are trying to understand molecular mechanisms for reorganization of chromosomes during the transition from mitosis to meiosis using fission yeast. Toward this end, we searched for meiosis-specific protein complexes within the nucleus by fluorescence microscopy in conjunction with molecular genetic analysis. We identified protein complexes that mediate chromosome reorganization and that mediate homologous chromosome pairing.
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[Journal Article] A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.2011
Author(s)
Y. Chen, R. Rai, Z.R. Zhou, J. Kanoh, C. Ribeyre, Y. Yang, H. Zheng, P. Damay, F. Wang, H. Tsujii, Y. Hiraoka, D. Shore, H.Y. Hu, S. Chang, M. Lei
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Journal Title
Nat.Struct.Mol.Biol. 18
Pages: 213-221
Peer Reviewed
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[Journal Article] MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.2010
Author(s)
S. Ito, L.-J. Tan, D. Andoh, T. Narita, M. Seki, Y. Hirano, K. Narita, I. Kuraoka, Y. Hiraoka, K. Tanaka
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Journal Title
Mol.Cell 39
Pages: 632-640
Peer Reviewed
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