2010 Fiscal Year Final Research Report
Molecular signaling in neuromuscular synaptogenesis, hematopoiesis, and related disorders
| Project/Area Number |
20247024
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Osamu 東京大学, 医科学研究所, 准教授 (50361720)
MASHIMA Ryuichi 東京大学, 医科学研究所, 助教 (00401365)
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| Project Period (FY) |
2008 – 2010
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| Keywords | シグナル伝達 / アダプター / タンパク質チロシンキナーゼ |
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| Research Abstract |
To understand molecular signaling involved in neuromuscular synaptogenesis, hematopoiesis, and related disorders, we focused on the Dok-family of adaptor proteins. Our findings together revealed that the cytoplasmic protein Dok-7 directly interacts with the receptor tyrosine kinase MuSK and activates it to form neuromuscular synapses. We also revealed that autoantibodies to Lrp4, a MuSK's coreceptor, in patients with myasthenia gravis, and that Dok-1/2/3 suppress histiocytic sarcoma.
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[Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive hisitocytic sarcoma2010
Author(s)
Ryuichi Mashima, Honda Kazuho, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, and Yuji Yamanashi
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Journal Title
Lab. Investigation
Volume: 90
Pages: 1357-1364
Peer Reviewed
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[Journal Article] Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARγphosphorylation.2008
Author(s)
Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, Takehiro Nakamura, Hiroshi Sakaue, Hiroshi Inoue, Wataru Ogawa, Kazutoshi Tobimatsu, Kazuo Takazawa, Mashito Sakai, Yasushi Matsuki, Ryuji Hiramatsu, Tomoharu Yasuda, Mitchell A
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Journal Title
Nature Med
Volume: 14
Pages: 188-193
Peer Reviewed
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