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2010 Fiscal Year Final Research Report

Elucidation of the aging process of human heat adaptability and strategies for delaying it

Research Project

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Project/Area Number 20247035
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied anthropology
Research InstitutionOsaka International University

Principal Investigator

INOUE Yoshimitsu  Osaka International University, 人間科学部, 教授 (70144566)

Co-Investigator(Kenkyū-buntansha) KOGA Syunsaku  神戸芸術工科大学, デザイン学部, 教授 (50125712)
KONDO Narihiko  神戸大学, 人間発達環境学研究科, 教授 (70215458)
UEDA Hiroyuki  大阪信愛女学院短期大学, 看護学科, 教授 (00203448)
ISHIZASHI Hiromichi  奈良県立医科大学, 医学部, 准教授 (50260807)
SHIBASAKI Manabu  奈良女子大学, 生活環境学部, 准教授 (00314526)
OUMI Masato  大阪大学, 大学院・医学系研究科, 助教 (60273645)
Project Period (FY) 2008 – 2010
Keywords環境適応能 / 全身的協関 / 高齢者 / 体温調節 / 発汗 / 循環調節
Research Abstract

This research project addressed the ways in which human heat adaptability changes with aging from the viewpoint of whole body coordination. Our findings suggest that in men and women, age-related decrement in thermoregulatory function may involve the input system, effector system, output system, and central system in that order, and the decrement in sweat gland function in the lower limbs may proceed from the lower legs to thigh and from posterior to anterior areas. Our results suggest that non-thermal heat loss response to combined input and sex differences in heat loss responses in young adults tended to decrease with aging. They also suggest that the enhancement of peripheral sweat function toward summer was delayed with aging, the contribution of the skin blood flow adjustment to orthostatic tolerance during the summer heat is smaller in older people, and older people are more prone to thrombogenesis in the summer. Although we failed to find a strategy to delay aging of input and output systems of the thermoregulatory function, the establishment of an exercise habit is effective for the effector system.

  • Research Products

    (29 results)

All 2011 2010 2009 2008 Other

All Journal Article (14 results) Presentation (6 results) Book (6 results) Remarks (3 results)

  • [Journal Article] Reply to C. Schwiening's commentary.2011

    • Author(s)
      CD Ichinose-Kuwahara T, Inoue Y
    • Journal Title

      Exp Physiol 96

      Pages: 559-560

  • [Journal Article] Sex differences in the effects of physical training on sweat gland responses during a graded exercise.2010

    • Author(s)
      Ichinose-Kuwahara T, Inoue Y, Iseki Y, et al.
    • Journal Title

      Exp Physiol 95

      Pages: 1026-1032

  • [Journal Article] Non-thermal modification of heat-loss responses during exercise in human.2010

    • Author(s)
      Kondo N. Nishiyasu T, Inoue Y. Koga S
    • Journal Title

      Eur J Appl Physiol 110

      Pages: 447-458

  • [Journal Article] Cutaneous vasodilation response to a linear increase in air temperature from 28℃ to 40℃ in prepubertal boys and young men.2009

    • Author(s)
      Inoue Y, Ichinose-Kuwahara T, Naka mura S, et al.
    • Journal Title

      J Physiol Anthropol 28

      Pages: 137-144

  • [Journal Article] Sweat gland function in Thai and Japanese Males in relation to physical training.2009

    • Author(s)
      Inoue Y, Ueda H, Kubota T, et al.
    • Journal Title

      Environmental Ergonomics 13

      Pages: 276-279

  • [Journal Article] Enhanced heat loss responses induced by short-term endurance training in exercising women.2009

    • Author(s)
      Ichinose-Kuwahara T, Inoue Y, Hirata M, et al.
    • Journal Title

      Exp Physiol 94

      Pages: 90-102

  • [Journal Article] Evaluation of the dynamics of muscle oxygenation by near-infrared-based tissue oximeters. (Reply to the Letter of Quaresima and Ferrari).2009

    • Author(s)
      Jones A, Koga S, et al.
    • Journal Title

      J Appl Physiol 107

      Pages: 372-373

  • [Journal Article] Effects of prior heavy exercise on heterogeneity of muscle deoxygenation kinetics during subsequent heavy exercise.2009

    • Author(s)
      R Saitoh T, Koga S, et al.
    • Journal Title

      Am J Physiol 297

      Pages: R615-621

  • [Journal Article] Neural and non-neural control of skin blood flow during isometric handgrip exercise in the heat stressed human.2009

    • Author(s)
      Shibasaki M, et al.
    • Journal Title

      J Physiol (London) 587

      Pages: 2101-2107

  • [Journal Article] Botulinum toxin abolishes sweating via impaired sweat gland responsiveness to exogenous acetylcholine.2009

    • Author(s)
      Shibasaki M, et al.
    • Journal Title

      Br J Dermatol 161

      Pages: 757-761

  • [Journal Article] Decreased ADAMTS13 levels in patients after living donor liver transplantation.2009

    • Author(s)
      Kobayashi T, Ishizashi H, et al
    • Journal Title

      Thrombosis Research 124

      Pages: 541-545

  • [Journal Article] Changes in blood flow in conduit artery and veins of the upper arm during leg exercise in humans.2008

    • Author(s)
      Ooue A, Ichinose TK, Inoue Y, et al.
    • Journal Title

      Eur J Appl Physiol 103

      Pages: 367-373

  • [Journal Article] Effects of chemoreflexes on hyperthermic hyperventilation and cerebral blood velocity in resting heated humans.2008

    • Author(s)
      Fujii N, Honda Y, Hayashi K, Kondo N, Koga S. Nishiyasu T
    • Journal Title

      Exp Physiol 93

      Pages: 994-1001

  • [Journal Article] Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine.2008

    • Author(s)
      Shibasaki M, et al.
    • Journal Title

      J Appl Physiol 105

      Pages: 1504-1508

  • [Presentation] 発汗機能の老化.人類学関連学会協議会合同シンポジウム2010

    • Author(s)
      井上芳光
    • Organizer
      加齢-老いの生態をめぐって-
    • Place of Presentation
      仙台
    • Year and Date
      20101000
  • [Presentation] 暑熱適応能の老化とその遅延策2010

    • Author(s)
      井上芳光
    • Organizer
      第18回運動生理学会シンポジウム
    • Place of Presentation
      鹿児島
    • Year and Date
      20100700
  • [Presentation] 高齢者の発汗機能2010

    • Author(s)
      井上芳光
    • Organizer
      第10回日本抗加齢医学会総会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      20100600
  • [Presentation] 老若男女の暑熱適応能2008

    • Author(s)
      井上芳光
    • Organizer
      建築学会環境工学委員会(第38回熱シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      20080700
  • [Presentation] 熱放散反応の老化過程:全身協関的視点からのアプローチ2008

    • Author(s)
      井上芳光
    • Organizer
      日本生理人類学会第58回大会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      20080600
  • [Presentation] よい汗2008

    • Author(s)
      井上芳光
    • Organizer
      日本生理人類学会第59回大会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      20080100
  • [Book] 体温II(井上芳光,近藤徳彦編著)2010

    • Author(s)
      井上芳光,近藤徳彦,他
    • Publisher
      ナップ
  • [Book] からだと温度の事典(彼末一之監修)2010

    • Author(s)
      井上芳光
    • Total Pages
      535-540
    • Publisher
      朝倉書店
  • [Book] スポーツサイエンス入門(田口貞善, ら編)2010

    • Author(s)
      井上芳光
    • Total Pages
      134-145
    • Publisher
      丸善出版
  • [Book] 健康運動指導士養成講習会テキスト2010

    • Author(s)
      近藤徳彦,井上芳光
    • Total Pages
      241-254
    • Publisher
      社会保険研究所
  • [Book] カラダの百科事典(生理人類学会編)2009

    • Author(s)
      井上芳光,他
    • Total Pages
      343-346, 420-424
    • Publisher
      丸善出版
  • [Book] 身体トレーニング(宮村実晴編)2009

    • Author(s)
      井上芳光,他
    • Total Pages
      355-361, 362-366
    • Publisher
      真興交易医書出版
  • [Remarks] 井上芳光:NHK総合テレビ「クローズアップ現代(2010年9月2日放映)」をはじめ,テレビ・ラジオに2008-2010年度で16回出演し,高齢者はなぜ暑さに弱いのか,さらにその老化遅延策を解説した.

  • [Remarks] 井上芳光:朝日新聞「夏のお出かけ恐怖の熱中症(2010年8月3日朝刊)」をはじめ,新聞・雑誌に2008-2010年度で12回,高齢者の熱中症予防策などのコメントが掲載された.

  • [Remarks] 井上芳光:上記の雑誌論文(2)がPressreleaseされ,その内容がBBC, New York Timesをはじめ世界の新聞・雑誌に掲載された.

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Published: 2012-01-26   Modified: 2016-04-21  

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