2012 Fiscal Year Final Research Report
Search for antitumor marine natural products through growth recovery assay in engineered yeasts
| Project/Area Number |
20248022
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUNAGA Shigeki 東京大学, 大学院・農学生命科学研究科, 教授 (60183951)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Minoru 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 主任研究員 (80191617)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 天然物化学 |
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| Research Abstract |
Most important issue in the natural products discovery study is how to link the high-through-put in vitro assay results and cell-based in vivo activities. The growth recovery assay of the otherwise lethal gene-overexpressing mutant yeasts constructed by Dr. Yoshida is a method of choice for such purposes. From the extracts of marine invertebrates we isolated two truncated thiamine derivatives from the marine sponge Theonella swinhoei and three steroid glycosides from an unidentified marine sponge.
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