2011 Fiscal Year Final Research Report
Studies on Brain Actions of the Steroid/Growth Factor System
| Project/Area Number |
20248030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIHARA Masugi 東京大学, 大学院・農学生命科学研究科, 教授 (90145673)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANOUCHI Keitaro 東京大学, 大学院・農学生命科学研究科, 准教授 (70272440)
MATSUWAKI Takashi 東京大学, 大学院・農学生命科学研究科, 特任助教 (20447361)
TAKAHASHI Shin-ichiro 東京大学, 大学院・農学生命科学研究科, 准教授 (00197146)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 脳・神経 / ステロイドホルモン / 成長因子 / プログラニュリン / 神経新生 / 神経変性 / 性分化 |
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| Research Abstract |
This study was conducted to elucidate the role of sex steroid/growth factor systems in sexual differentiation of the brain during perinatal period and neuroprotection as well as neurogenesis after maturation. By the studies using progranulin(PGRN)-deficient mice we have generated, we found that PGRN mediates the brain actions of estrogens and modulates brain sexual differentiation, neurogenesis in the dentate gyrus of the hippocampus and neurodegeneration. It is also demonstrated that PGRN plays a role in regulating the activation of microglia after traumatic brain injury. In addition, it is suggested that the actions of PGRN in the brain is transduced through glycogen synthase kinase 3βphosphorylation, and mediated by genes/proteins containing LIM domain.
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[Journal Article] Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging2010
Author(s)
Ahmed Z, Sheng H, Xu YF, Lin WL, Innes A, Yu X, Hou H, Chiba S, Yamanouchi K, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson D, Lewis J
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Journal Title
Am J Pathol
Volume: 177
Pages: 311-324
DOI
Peer Reviewed
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[Journal Article] Proteolytic processing of tar DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin2009
Author(s)
Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C
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Journal Title
J Neurochem
Volume: 110
Pages: 1082-1094
DOI
Peer Reviewed
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