2010 Fiscal Year Final Research Report
A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization
| Project/Area Number |
20248032
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MATSUDA Hiroshi Tokyo University of Agriculture and Technology, 大学院・農学研究院, 教授 (80145820)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Akane 東京農工大学, 大学院・農学研究院, 准教授 (80418673)
OHMORI Keitaro 東京農工大学, 大学院・農学研究院, 助教 (20466915)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 低酸素反応性因子 / 癌 / 遺伝子治療 |
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| Research Abstract |
In a malignant solid carcinoma, proliferation of cancer cells are sometimes accelerated after a surgery and radiation therapy and a cancer may recur in a short term. It is thought that a cancer stem cell of the drug resistance and the high vascularization inducibility bring the rapid expansion of the cancer tissue, but the control method is not yet found. Based on the author's past research on mast cell tumors, we evaluated a silencing therapy or a gene control therapy for the endogenous inhibitors for vascularization and hypoxia inducible factors which controlled neo-vascularization. We developed effective therapy for controlling neo-vascularization. In addition, we elucidated mechanism of the drug resistance of cancer stem cells and obtained fundamental researche data for establishment of a novel therapy.
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