2011 Fiscal Year Final Research Report
Asymmetric Addition of carbon, nitrogen, oxygen and sulfur nucleophiles and its application to the synthesis of biologically active compounds
| Project/Area Number |
20249002
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts (2011)
Kyoto University (2008-2010) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Ken-ichi 京都大学, 薬学研究科, 准教授 (00335184)
YAMAMOTO Yasutomo 同志社女子大学, 薬学部, 助教 (10452278)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 四大元素 / キラル配位子 / 不斉触媒 / 天然物合成 / 連続反応 |
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| Research Abstract |
Most chiral carbon centers of biologically active compound directly connect to representative 4 atoms, carbon, nitrogen, oxygen, and sulfur atoms. Asymmetric addition reaction of these 4 atoms develops the methodology for the efficient synthesis of useful medicines and biologically active molecules. We achieved asymmetric addition of organolithiums, lithium enolates, lithium amides, organoboranes, organomagnesiums, and organozincs. Asymmetric total synthesis of some natural products was also achieved by using our developed asymmetric reaction as a key step.
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