2011 Fiscal Year Final Research Report
Efficient Creation of Drug-functional Molecules with Chemically Evolutional Synthetic Chemistry
| Project/Area Number |
20249006
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Naoki 名古屋市立大学, 大学院・薬学研究科, 准教授 (40347422)
KATO Nobuki 名古屋市立大学, 大学院・薬学研究科, 助教 (50400221)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAIZUMI Yuji 名古屋市立大学, 大学院・薬学研究科, 教授 (60117794)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 化学平衡 / 親和性 / ダイナミックコンビナトリアルケミストリー / 創薬手法 |
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| Research Abstract |
We have succeeded in the development of 2, 4, 6-triethyl-1, 3, 5-di(alkylamino) benzene dynamic combinatorial library having affinity to hemin by utilizing aldehyde/amine-imine equilibrium reaction between 2, 4, 6-triethyl-1, 3, 5-benzenetricarbaldehyde(1) scaffold and amines. Increased products in the presence of hemin had higher affinity with hemin than not increased products. Porphyrin having four aldehyde precursors as a scaffold was synthesized. Equilibrium reaction between scaffold 1 and boomerang-form diamines converged to a cage-type supramolecule mainly.
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