2010 Fiscal Year Final Research Report
Development of new therapeutic agents for brain tumor using protein therapy
| Project/Area Number |
20249009
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Okayama University |
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Principal Investigator |
MATSUI Hideki Okayama University, 大学院・医歯薬学総合研究科, 教授 (30157234)
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| Co-Investigator(Renkei-kenkyūsha) |
MICHIUE Hiroyuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20572499)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳腫瘍 / 悪性グリオーマ / タンパク質セラピー法 / タンパク質導入 / 中性子捕捉療法 |
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| Research Abstract |
Boron neutron capture therapy (BNCT) is a novel cancer treatment modality that can selectively target the tumor without causing excessive radiation damage to the normal tissues. In this project, we developed 2 types of new therapeutic agents for BNCT : cell-penetrating peptides using the protein therapy or nanoparticles, which are effective of delivering cargo into cells, to deliver ^<10>B into the tumor cells as BNCT agents. In both in-vitro studies using the cultured tumor cells and in-vivo studies using tumor-bearing mice, these agents were only observed in the tumor. The results suggest that our systems utilizing peptides or nanoparticles provide an effective means of delivering ^<10>B into tumor cells selectively in BNCT.
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