2010 Fiscal Year Final Research Report
Studies on the structure-activity relationship on pharmacological modulations of potassium channels
| Project/Area Number |
20249012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
KURACHI Yoshihisa Osaka University, 大学院・医学系研究科, 教授 (30142011)
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| Co-Investigator(Kenkyū-buntansha) |
INANOBE Atsushi 大阪大学, 医学系研究科, 准教授 (00270851)
HIBINO Hiroshi 新潟大学, 医歯学系, 教授 (70314317)
MURAKAMI Shingo 大阪大学, 医学系研究科, 助教 (40437314)
FURUTANI Kazuharu 大阪大学, 医学系研究科, 助教 (40452437)
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| Project Period (FY) |
2008 – 2010
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| Keywords | イオンチャネル / 内向き整流性カリウムチャネル / 電位依存性カリウムチャネル / 薬物-チャネル相互作用 / 構造活性相関 / 薬理学 / 生物物理学 |
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| Research Abstract |
Ion channel functions are modulated by the drugs. However, the mechanisms underling drug actions are often not well understood. In this study, we examined the mechanisms of drug actions in inward-rectifier potassium channels and voltage-dependent potassium channel. Our studies reveal structural bases of drug-channel interactions and their functional alterations in potassium channel. Moreover, our results provide better understandings of their clinical efficacy or undesirable side effects, and shed light on the rational development of pharmacological agents.
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Research Products
(46 results)
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[Journal Article] on behalf of the J-RHYTHM II Investigators. Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II Study).2011
Author(s)
Yamashita T, Inoue H, Okumura K, Kodama I, Aizawa Y, Atarashi H, Ohe T, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Koretsune Y, Saikawa T, Sakurai M, Sato T, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E, Ogawa S
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Journal Title
Europace 13(4)
Pages: 473-479
Peer Reviewed
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[Journal Article] A platform for in silico modeling of physiological systems III.2009
Author(s)
Suzuki Y, Asai Y, Oka H, Heien E, Urai T, Okamoto T, Yumikura Y, Tominaga K, Kido Y, Nakanishi M, Hagihara K, Kurachi Y, Nomura T.
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Journal Title
Conf Proc IEEE Eng Med Biol Soc. 2009
Pages: 2803-2806
Peer Reviewed
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[Journal Article] Optimal treatment strategy for patients with paroxysmal atrial fibrillation : J-RHYTHM Study.2009
Author(s)
Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H.
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Journal Title
Circ J 73(2)
Pages: 242-248
Peer Reviewed
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