2011 Fiscal Year Final Research Report
Analysis of cancer suppressor gene PTEN and its regulation
| Project/Area Number |
20249019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SUZUKI Akira 九州大学, 生体防御医学研究所, 教授 (10311565)
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| Project Period (FY) |
2008 – 2011
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| Keywords | PTEN / PICT1 / GLTSCR2 / P53 |
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| Research Abstract |
We generated various tissuespecific PTENdeficient mice and found the novel functions of PTEN in vivo.(2) We found PICT1 binds and stabilizes PTEN protein. Moreover, we found PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus.(3) We found PBP1 binds and activates lipid phosphatase activity of PTEN, and strongly represss the Akt activation in vitro. Thus, we found the novel functions of PTEN and the mechanism of its regulation.
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