2011 Fiscal Year Final Research Report
Identification and characterization of host factors involved in transcription and replication of the influenza virus genome
| Project/Area Number |
20249025
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
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| Project Period (FY) |
2008 – 2011
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| Keywords | インフルエンザウイルス / 宿主因子 / ゲノム複製 / 転写 / RNA依存性RNAポリメラーゼ / 酵母レプリコン系 |
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| Research Abstract |
We have focused our study on the identification and characterization of host factors involved in the replication and transcription of the influenza virus genome. We have purified and identified a number of host factors, which stimulate the viral genome replication and transcription, by dissecting and reconstituting a cell-free influenza virus RNA synthesis system. Further, we also established an yeast-based influenza virus replicon system and identified host factors by genome-wide screening system using an yeast single-gene deletion library.
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[Journal Article] Anti-influenza virus compound from Streptomyces sp2010
Author(s)
Takagi M, Motohashi K, Nagai A, Izumikawa M, Tanaka M, Fuse S, Doi T, Iwase K, Kawaguchi A, Nagata K, Takahashi T, Shin-Ya K
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Journal Title
RI18. Org. Lett
Volume: 12
Pages: 4664-4666
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[Journal Article] Epigenetic control of rDNA loci in response to intracellular energy status2008
Author(s)
Murayama A, Omori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, Yanagisawa J
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Journal Title
Cell
Volume: 133
Pages: 627-639
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[Journal Article] Wild-type measles virus with thehemagglutinin protein of the edmonston vaccine strain retains wild-type tropism in macaques
Author(s)
Takeuchi K, Nagata N, Kato SI, Ami Y, Suzuki T, Sato Y, Tsunetsugu-Yokota Y, Mori K, Van Nguyen N, Kimura H, Nagata K
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Journal Title
J. Virol
Volume: (In press)
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