2010 Fiscal Year Final Research Report
Activation of Zinc signal and its biological significance
| Project/Area Number |
20249030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
HIRANO Toshio Osaka University, 生命機能研究科, 教授 (40136718)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masaaki 大阪大学, 生命機能研究科, 准教授 (00250514)
KAMIMURA Daisuke 大阪大学, 生命機能研究科, 助教 (20391922)
FUKUSHIMA Toru 大阪大学, 医学系研究科, 助教 (60447977)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKADA Toshiyuki 理化学研究所, 免疫アレルギー総合科学研究センター, 上級研究員 (70373363)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 亜鉛 / 亜鉛トランスポーター / Zip13 / STAT3 / 免疫反応 |
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| Research Abstract |
We here attempt to investigate intracellular Zn signaling, which is important for cell fate and/or cell activation status determination followed by various diseases and disorders. We mainly have three results, which are obtained by this grant. (I) Investigation of intracellular Zn signals, (II) Molecular basis of Zn signal to analyze Zn-binding sites in the target molecules and their mechanism, and (III) in vivo significances of Zn signal using various Zn-related molecule deficient mice and several disease/disorder models.
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[Journal Article] Zinc suppresses Thdevelopment via inhibition of STAT3 activation.2010
Author(s)
Kitabayashi C., T.Fukada, M.Kanamoto, W.Ohashi, S.Hojyo, T.Atsumi, N.Ueda, I.Azuma, H.Hirota, M.Murakami, T.Hirano
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Journal Title
Int.Immunol. 22(5)
Pages: 375-386
Peer Reviewed
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[Journal Article] The Zinc Transporter SLC39A13/ZIP13 is Required for Connective Tissue Development ; Its Involvement in BMP/TGF-beta Signaling Pathways.2008
Author(s)
Fukada T., N.Civic, T.Furuichi, S.Shimoda, K.Mishima, H.Higashiyama, Y.Idaira, Y.Asada, H.Kitamura, S.Yamasaki, S.Hojyo, M.Nakayama, O.Ohara, H.Koseki, H.G.dos Santos, L.Bonafe, R.Ha-Vinh, A.Zankl, S.Unger, M.E.Kraenzlin, J.S.Beckmann, I.Saito, C.Rivolta, S.Ikegawa, A.Superti-Furga, T.Hirano
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Journal Title
PLoS ONE 3(11)
Pages: e3642
Peer Reviewed
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[Presentation] International Symposium "Towards Comprehensive Understanding of Immune Dynamism", "Zinc Prevents Th17 Cell-Mediated Autoimmune Disease by Directly Inhibiting STAT3"2011
Author(s)
C.Kitabayashi1, T.Fukada, M.Kanamoto, N.Ueda, W.Ohashi, S.Hojyo, I.Azuma, H.Hirota, M.Murakami, T.Hirano
Organizer
Senri Hankyu Hotel & Osaka University
Place of Presentation
Osaka
Year and Date
20110301-20110302
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[Presentation] Zinc and Th17-mediated autoimmune diseases2010
Author(s)
Masaaki Murakami, Chika Kitabayashi, Toshiyuki Fukada, Minoru Kanamoto, Wakana Ohashi, Shintaro Hojyo, Toru Atsumi, Naoko Ueda, Ichiro Azuma, Hiroshi Hirota, Toshio Hirano
Organizer
The 60^<th> Fujihara Seminar Zinc Signaling and Cellular Functions
Place of Presentation
Osaka International Convention Center
Year and Date
20101029-20101031
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[Presentation] Zinc and CD4+ T cell-mediatautoimmune diseases2010
Author(s)
Masaaki Murakami, Chika Kitabayashi, Toshiyuki Fukada, Minoru Kanamoto, Wakana Ohashi, Shintaro Hojyo, Toru Atsumi, Naoko Ueda, Ichiro Azuma, Hiroshi Hirota, Tosh Hirano
Organizer
The 60^<th> Fujihara Seminar Zinc Signaling and Cellular Functions
Place of Presentation
OsakaInternational Convention Center
Year and Date
20101029-20101031
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[Presentation] Zinc-mediated STAT3 suppression is involved in inhibition of autoimmune disease development via regulating Th17 differentiation.2010
Author(s)
Chika Kitabayashi, Toshiyuki Fukada, Minoru Kanamoto, Wakana Ohashi, Shintaro Hojyo, Toru Atsumi, Naoko Ueda, Ichiro Azuma, Hiroshi Hirota, Masaaki Murakami, Toshio Hirano
Organizer
14^<th> International Congress of Immunology (第14回国際免疫学会議)
Place of Presentation
Kobe, Japan
Year and Date
20100822-20100827
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