2010 Fiscal Year Final Research Report
PHARMACOKINETICS IN THE PATIENTS WITH METABOLIC SYNDROME AND APPLICATION FOR PHARMACOTHERAPY
| Project/Area Number |
20249036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
INUI Ken-ichi Kyoto University, 医学研究科, 名誉教授 (70034030)
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| Co-Investigator(Kenkyū-buntansha) |
KATSURA Toshiya 京都大学, 医学研究科, 准教授 (10283615)
MASUDA Satoshiro 京都大学, 医学研究科, 講師 (90303825)
TERADA Tomohiro 京都大学, 医学研究科, 薬剤部副薬剤部長 (10324641)
YONEZAWA Atsushi 京都大学, 医学研究科, 助教 (90452341)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 薬学 / 薬剤反応 / 薬物トランスポータ / 転写因子 / 核内受容体 / メトホルミン |
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| Research Abstract |
Drug response is likely altered in the patient with metabolic syndrome. The present results indicated that the expression levels of drug transporters were varied, and pharmacokinetics was changed in several diseases. Especially, we clearly revealed that an efflux transporter MATE1 could influence the sensitivities of anti-diabetic drug metformin and anti-cancer drug cisplatin. These outcomes can lead to the optimized pharmacotherapy in metabolic syndrome patients.
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[Journal Article] Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss : a prospective clinical trial.2010
Author(s)
Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, Ono K, Yamamoto M, Tabata Y, Teramukai S, Tanaka S, Tada H, Onodera R, Yonezawa A, Inui K, Ito J.
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Journal Title
Peer Reviewed
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[Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010
Author(s)
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K.
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Journal Title
Pharmacogenet Genomics 20
Pages: 135-138
Peer Reviewed
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[Journal Article] Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis.2010
Author(s)
Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, Ueno S, Uza N, Masuda S, Inui K, Chiba T.
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Journal Title
Inflamm Bowel Dis 16
Pages: 2022-2033
Peer Reviewed
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[Journal Article] SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.2009
Author(s)
Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, 以下11名
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Journal Title
J Am Soc Nephrol 20
Pages: 2546-2555
Peer Reviewed
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