2010 Fiscal Year Final Research Report
Immunological analysis and new immunotherapy of chronic hepatitis C
| Project/Area Number |
20249043
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
MOCHIZUKI Kiyoshi Osaka University, 医学系研究科, 助教 (50467578)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Norio 大阪大学, 医学系研究科, 教授 (00144478)
TAKEHARA Tetsuo 大阪大学, 医学系研究科, 教授 (70335355)
KANTO Tatsuya 大阪大学, 医学系研究科, 寄附講座准教授 (80372613)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ウイルス肝炎 / NK細胞 / 樹状細胞 / ノックアウト / 制御性T細胞 |
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| Research Abstract |
The aim of this study is to analyze the immunological pathogenesis of chronic hepatitis C (CHC). The innate immune system recognizing hepatitis C virus (HCV) in myeloid dendritic cells was impaired in CHC patients. The IFN-α signaling in NK cells altered in CHC patients and this was associated with the outcome of the peg-IFN-α/ribavirin combination therapy. The early induction of HCV-specific CTL responses plays an important role in the eradication of HCV by this combination therapy. The impairment of activation of NKT cells could be occurred in tumor-bearing host and the generation of regulatory T cells could also be occurred in the presence of dendritic cells and HCC cells. These results might contribute to the development of future immunotherapy against CHC and HCC.
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