2010 Fiscal Year Final Research Report
Role of diseased angiogenesis in diabetic cardiomyopathy and its significance for the invention of novel therapeutic strategy.
| Project/Area Number |
20249045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MUROHARA Toyoaki Nagoya University, 医学系研究科, 教授 (90299503)
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| Co-Investigator(Kenkyū-buntansha) |
SHINTANI Satoshi 名古屋大学, 大学院・医学研究科, 講師 (20309777)
BANDO Yasuko 名古屋大学, 大学院・医学研究科, 助教 (60452190)
MAEDA Kengo 名古屋大学, 医学部付属病院, 助教 (80456673)
SHIBATA Rei 名古屋大学, 大学院・医学研究科, 特任講師 (70343689)
TAKESHITA Kyosuke 名古屋大学, 医学部付属病院, 講師 (70444403)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖尿病 / 糖尿病性心筋症 / 血管新生 |
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| Research Abstract |
Mismatch between cardiomyocyte growth and reduced coronary angiogenesis promotes maladaptive cardiac remodeling including diabetic cardiomyopathy. Diabetes enhances cardiac aminopeptidase activity which promotes degradation in angiogenic chemokine SDF1-α, leading to reduced coronary angiogenesis and resultant cardiac remodeling. Our data suggest that regulation of cardiac aminopepetidase activity may be essential for therapeutic strategy of maladaptive cardiac remodeling in diabetes.
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[Journal Article] Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.2008
Author(s)
Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M.
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Journal Title
Nat.Cell Biol. 10
Pages: 329-337
Peer Reviewed
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