Relationships among skeletal, adipose and vasclar regulatory system, and elucidation of pathogensis caused by disturbances of these systems

2010 Fiscal Year Final Research Report

• Project/Area Number: 20249050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: The University of Tokushima
• Principal Investigator: MATSUMOTO Toshio The University of Tokushima, 大学院・ヘルスバイオサエン研究部, 教授 (20157374)
• Co-Investigator(Kenkyū-buntansha): ABE Masahiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (80263812) ; AIHARA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372711) ; FUJINAKA Yuichi 徳島大学, 病院, 講師 (30432751) ; ENDO Itsuro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10432759)
• Project Period (FY): 2008 – 2010
• Keywords: 内科 / 老化 / 多発性骨髄腫 / 骨粗鬆症 / 糖尿病 / 動脈硬化

Research Abstract

IL-11 gene transcription is enhanced by mechanical stress to bone, and IL-11 stimulates osteoblast differentiation and bone formation via activation of canonical Wnt signaling. TGF-・inhibitor enhances osteoblast differentiation, and mature osteoblasts inhibit myeloma cell proliferation. Thus, TGF-・inhibition can become a new therapeutic approach against multiple myeloma. Pitavastatin ameliorates left ventricular diastolic function and microalbumiuria via suppression of oxidative stress. A thrombin inhibitor, heparin cofactor II, inhibits migration and proliferation of vascular smooth muscle cells, and protects against atherosclerotic changes.

Research Products

• [Journal Article] The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells (2011)
  • Author(s): Asano J, Nakano A, Oda A, Amou H, Hiasa M, Takeuchi K, Miki H, Nakamura S, Harada T, Fujii S, Kagawa K, Endo I, Yata K-I, Sakai A, Ozaki S, Matsumoto T, Abe M
  • Journal Title: Leukemia in press
  • Peer Reviewed
• [Journal Article] Activation of Peroxisome Proliferator-activated Receptor alpha in Megakaryocytes Reduces Platelet-derived Growth Factor-BB in Platelets (2011)
  • Author(s): Hashizume S, Akaike M, Azuma H, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Aihara KI, Abe M, Sata M, Matsumoto T
  • Journal Title: J Atheroscler Thromb 18 Pages: 138-147
  • Peer Reviewed
• [Journal Article] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors. (2011)
  • Author(s): Ise T, Aihara K, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T
  • Journal Title: Hypertens Res 34 Pages: 225-231
  • Peer Reviewed
• [Journal Article] TGF-β-related mechanisms of bone destruction in multiplemyeloma. (2011)
  • Author(s): Matsumoto T, Abe M
  • Journal Title: Bone 48 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Chapter 11. Mechanosensing and Signaling Crosstalks. (2011)
  • Author(s): Matsumoto T, Kuriwaka-Kido R, Kido S
  • Journal Title: Mechanosensing Biology (Book) Edited by Noda, M Part 3 : Skeltal Response Pages: 157-166
  • Peer Reviewed
• [Journal Article] Delayed treatment with vitamin C and N-acetyl-L:-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib. (2011)
  • Author(s): Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T
  • Journal Title: Int J Hematol 93 Pages: 727-735
  • Peer Reviewed
• [Journal Article] Vitamin D Insufficiency Defined by Serum 25-Hydroxyvitamin D and Parathyroid Hormone Before and After Oral Vitamin D3 Load in Japanese Subjects. (2011)
  • Author(s): Okazaki R, Sugimoto T, Kaji H, Fujii Y, Shiraki M, Inoue D, Endo I, Okano T, Hirota T, Matsumoto T
  • Journal Title: J Bone Miner Metab 29 Pages: 103-110
  • Peer Reviewed
• [Journal Article] Transient inflammatory reaction during Ienalidomide plus reduced-dose dexamethasone therapy in two patients with relapsed multiple myeloma. (2011)
  • Author(s): Ozaki S, Harada T, Fujii S, Nakamura S, Miki H, Nakano A, Kagawa K, Takeuchi K, Abe M, Matsumoto T
  • Journal Title: Int J Hematol 93 Pages: 257-259
  • Peer Reviewed
• [Journal Article] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension. (2011)
  • Author(s): Yagi S, Akaike M, Aihara K, Iwase T, Yoshida S, Sumitomo-Ueda Y, Ikeda Y, Ishikawa K, Matsumoto T, Sata M
  • Journal Title: Hypertens Res 34 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Bosentan improves systemic sclerosis-related peripheral circulation insufficiency. (2011)
  • Author(s): Yagi S, Akaike M, Aihara KI, Iwase T, Sumitomo-Ueda Y, Yoshida S, Matsumoto T, Sata M
  • Journal Title: Int J Cardiol in press
  • Peer Reviewed
• [Journal Article] Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice. (2010)
  • Author(s): Ikeda Y, Aihara K, Akaike M, Sato T, Ishikawa K, Ise T, Yagi S, Iwase T, Ueda Y, Yoshida S, Azuma H, Walsh K, Tamaki T, Kato S, Matsumoto T
  • Journal Title: Mol Endocrinol 24 Pages: 1338-1348
  • Peer Reviewed
• [Journal Article] A defucosylated anti-CD317 antibody exhibited enhanced antibody-dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients. (2010)
  • Author(s): Ishiguro T, Kawai S, Habu K, Sugimoto M, Shiraiwa H, Iijima S, Ozaki S, Matsumoto T, Yamada-Okabe H
  • Journal Title: Cancer Sci 101 Pages: 2227-2233
  • Peer Reviewed
• [Journal Article] Mechanical Stress Activates Smad Pathway through PKC δ to Enhance Interleukin-11 Gene Transcription in Osteoblasts. (2010)
  • Author(s): Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T
  • Journal Title: PLoS ONE 5 Pages: e13090
  • Peer Reviewed
• [Journal Article] Validation of the Japanese Osteoporosis Quality of Life Questionnaire. (2010)
  • Author(s): Kumamoto K, Nakamura T, Suzuki T, Gorai I, Fujinawa O, Ohta H, Shiraki M, Yoh K, Fujiwara S, Endo N, Matsumoto T
  • Journal Title: J Bone Miner Metab 28 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism. (2010)
  • Author(s): Matsumoto T, Takano T, Yamakido S, Takahashi F, Tsuji N
  • Journal Title: J Steroid Biochem Mol Biol 121 Pages: 261-264
  • Peer Reviewed
• [Journal Article] Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice. (2010)
  • Author(s): Mihara M, Aihara K, Ikeda Y, Yoshida S, Kinouchi M, Kurahashi K, Fujinaka Y, Akaike M, Matsumoto T
  • Journal Title: Endocrinology 151 Pages: 513-519
  • Peer Reviewed
• [Journal Article] Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study : 12-month, randomized, placebo-controlled, double-blind and 12-month open-label phases. (2010)
  • Author(s): Miyauchi A, Matsumoto T, Sugimoto T, Tsujimoto M, Warner MR, Nakamura T
  • Journal Title: BONE 47 Pages: 493-502
  • Peer Reviewed
• [Journal Article] Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles. (2010)
  • Author(s): Nakamura M, Ozaki S, Abe M, Doi H, Matsumoto T, Ishimura K
  • Journal Title: Colloids Surf B Biointerfaces 79 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice. (2010)
  • Author(s): Sumitomo-Ueda Y, Aihara K, Ise T, Yoshida S, Ikeda Y, Uemoto R, Yagi S, Iwase T, Ishikawa K, Hirata Y, Akaike M, Sata M, Kato S, Matsumoto T
  • Journal Title: Hypertension 56 Pages: 430-436
  • Peer Reviewed
• [Journal Article] Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth. (2010)
  • Author(s): Takeuchi K, Abe M, Hiasa M, Oda A, Amou H, Kido S, Harada T, Tanaka O, Miki H, Nakamura S, Nakano A, Kagawa K, Yata K, Ozaki S, Matsumoto T
  • Journal Title: PLoS ONE 5 Pages: e9870
  • Peer Reviewed
• [Journal Article] Induction of endosomal/lysosomal pathways in differentiating osteoblasts as revealed by combined proteomic and transcriptomic analyses. (2010)
  • Author(s): Taniguchi T, Kido S, Yamauchi E, Abe M, Matsumoto T, Taniguchi H
  • Journal Title: FEBS Lett 584 Pages: 3969-3974
  • Peer Reviewed
• [Journal Article] Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury. (2010)
  • Author(s): Yagi S, Akaike M, Aihara K, Ishikawa K, Iwase T, Ikeda Y, Soeki T, Yoshida S, Sumitomo-Ueda Y, Matsumoto T, Sata M
  • Journal Title: Hypertension 55 Pages: 918-923
  • Peer Reviewed
• [Journal Article] Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia. (2010)
  • Author(s): Yagi S, Akaike M, Aihara K, Iwase T, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Kusunose K, Niki T, Yamaguchi K, Koshiba K, Hirata Y, Dagvasumberel M, Taketani Y, Tomita N, Yamada H, Soeki T, Wakatsuki T, Matsumoto T, Sata M
  • Journal Title: J Atheroscler Thromb 17 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function. (2010)
  • Author(s): Yoshida S, Aihara K, Azuma H, Uemoto R, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Nishio S, Kawano H, Miki J, Yamada H, Hirata Y, Akaike M, Sata M, Matsumoto T
  • Journal Title: Atherosclerosis 212 Pages: 310-315
  • Peer Reviewed
• [Journal Article] Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-lalpha and MIP-lbeta production. (2009)
  • Author(s): Abe M, Hiura K, Ozaki S, Kido S, Matsumoto T
  • Journal Title: J Bone Miner Metab 27 Pages: 16-23
  • Peer Reviewed
• [Journal Article] Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors. (2009)
  • Author(s): Aihara K, Azuma H, Akaike M, Kurobe H, Takamori N, Ikeda Y, Sumitomo Y, Yoshida S, Yagi S, Iwase T, Ishikawa K, Sata M, Kitagawa T, Matsumoto T
  • Journal Title: J Atheroscler Thromb 16 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Heparin cofactor II as a novel vascular protective factor against atherosclerosis. (2009)
  • Author(s): Aihara K, Akaike M, Sata M, Matsumoto T
  • Journal Title: J Atheroscler Thromb 16 Pages: 523-531
  • Peer Reviewed
• [Journal Article] Targeting Bone Remodeling for the Treatment of Osteoporosis : Summary of the Proceedings of an ASBMR Workshop. (2009)
  • Author(s): Bilezikian JP, Matsumoto T, Bellido T, Khosla S, Martin J, Recker RR, Heaney R, Seeman E, Papapoulos S, Goldring SR
  • Journal Title: J Bone Miner Res 24 Pages: 373-385
  • Peer Reviewed
• [Journal Article] Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvediolo therapy is a novel predictor of long-term outcome in patients with chronic heart failure. (2009)
  • Author(s): Fujimura M, Akaike M, Iwase T, Yoshida S, Sumitomo Y, Yagi S, Ikeda Y, Hashizume S, Aihara K, Nishiuchi T, Yasumura Y, Matsumoto T
  • Journal Title: Acta Cardiol 64 Pages: 589-595
  • Peer Reviewed
• [Journal Article] A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis. (2009)
  • Author(s): Hagino H, Nishizawa Y, Sone T, Morii H, Taketani Y, Nakamura T, Itabashi A, Mizunuma H, Ohashi Y, Shiraki M, Minamide T, Matsumoto T
  • Journal Title: BONE 44 Pages: 1078-1084
  • Peer Reviewed
• [Journal Article] GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE). (2009)
  • Author(s): Hiasa M, Abe M, Nakano A, Oda A, Amou H, Kido S, Takeuchi K, Kagawa K, Yata K, Hashimoto T, Ozaki S, Asaoka K, Tanaka E, Moriyama K, Matsumoto T
  • Journal Title: Blood 114 Pages: 4517-4526
  • Peer Reviewed
• [Journal Article] Androgen-androgen receptor system protects against angiotensin II-inducedvascular remodeling. (2009)
  • Author(s): Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, Akaike M, Kato S, Matsumoto T
  • Journal Title: Endocrinology 150 Pages: 2857-2864
  • Peer Reviewed
• [Journal Article] Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. (2009)
  • Author(s): Kido S, Kuriwaka-Kido R, Imamura T, Ito Y, Inoue D, Matsumoto T
  • Journal Title: BONE 45 Pages: 1125-1132
  • Peer Reviewed
• [Journal Article] Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma. (2009)
  • Author(s): Kitazoe K, Abe M, Hiasa M, Oda A, Amou H, Harada T, Nakano A, Takeuchi K, Hashimoto T, Ozaki S, Matsumoto T
  • Journal Title: Int J Hematol 89 Pages: 45-57
  • Peer Reviewed
• [Journal Article] Effect of daily oral minodronate on vertebral fractures in Japanese postmenopausal women with established osteoporosis : a randomized placebo-controlled double-blind study. (2009)
  • Author(s): Matsumoto T, Hagino H, Shiraki M, Fukunaga M, Nakano T, Takaoka K, Morii H, Ohashi Y, Nakamura T
  • Journal Title: Osteoporos Int 20 Pages: 1429-1437
  • Peer Reviewed
• [Journal Article] Marked improvement of platelet transfusion refractoriness after bortezomib therapy in multiple myeloma. (2009)
  • Author(s): Miki H, Ozaki S, Tanaka O, Lee E, Takimoto T, Watanabe H, Fujii S, Nakamura S, Kagawa K, Takeuchi K, Yata K, Abe M, Kagami S, Matsumoto T
  • Journal Title: Int J Hematol 89 Pages: 223-226
  • Peer Reviewed
• [Journal Article] Pinl down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. (2009)
  • Author(s): Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T
  • Journal Title: J Biol Chem 284 Pages: 6109-6115
  • Peer Reviewed
• [Journal Article] HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody. (2009)
  • Author(s): Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T, Sone S
  • Journal Title: Cancer Immunol Immunother 58 Pages: 967-976
  • Peer Reviewed
• [Journal Article] Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancercells. (2009)
  • Author(s): Wang W, Nishioka Y, Ozaki S, Jalili A, Verma V, Hanibuchi M, Abe S, Minakuchi K, Matsumoto T, Sone S
  • Journal Title: Lung Cancer 63 Pages: 23-31
  • Peer Reviewed
• [Journal Article] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement. (2008)
  • Author(s): Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T
  • Journal Title: Bone 42 Pages: 1235-1239
  • Peer Reviewed
• [Journal Article] Causes and differential diagnosis of hypocalcemia -Recommendation proposed by expert panel supported by Ministry of Health, Labour and Welfare, Japan-. (2008)
  • Author(s): Fukumoto, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T
  • Journal Title: Endocr J 55 Pages: 787-794
  • Peer Reviewed
• [Journal Article] Effect of Teriparatide on Bone Mineral Density and Biochemical Markers in Japanese Women with Postmenopausal Osteoporosis : a 6-month Dose-response Study. (2008)
  • Author(s): Miyauchi A, Matsumoto T, Shigeta H, Tsujimoto M, Thiebaud D, Nakamura T
  • Journal Title: J Bone Miner Metab 26 Pages: 624-634
  • Peer Reviewed
• [Journal Article] Pitavastatin, an HMG-GoA Reductase Inhibitor, Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency. (2008)
  • Author(s): Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T
  • Journal Title: Circ Res 102 Pages: 68-76
  • Peer Reviewed
• [Presentation] Serum ICTP can be a surrogate marker of coronary unstable plaques (2010)
  • Author(s): 遠藤逸朗
  • Organizer: ASBMR 2010 Annual Meeting
  • Place of Presentation: Metro Toronto Convention
  • Year and Date: 2010-10-15
• [Presentation] TIMP-3 up-regulation facilitates osteoclastogenesis and suppresses DC differentiation from monocytes in the bone marrow microenvironment in myeloma (2010)
  • Author(s): 安倍正博
  • Organizer: 10th International Conference Cancer-Induced Bone Disease (Invited Speaker)
  • Place of Presentation: Sheffield, United Kingdom
  • Year and Date: 2010-09-22
• [Presentation] 新しいビタミンDによる骨折予防 (2010)
  • Author(s): 松本俊夫
  • Organizer: 第83回日本整形外科学会総会(教育講演)
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2010-05-27
• [Presentation] Heparin cofactor II is a novel anticardiac remodeling factor against angiotensin II excess (2010)
  • Author(s): 粟飯原賢一
  • Organizer: 20th International Society for Heart Research
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-05-14
• [Presentation] ロスバスタチンによる心筋リモデリング抑制効果の検討 (2010)
  • Author(s): 粟飯原賢一
  • Organizer: 第83回日本内分泌学術総会
  • Place of Presentation: 京都(国立京都会館)
  • Year and Date: 2010-03-25
• [Presentation] Facilitation of osteoblast differentiation by ATF-4accumulation through proteasome inhibition (2009)
  • Author(s): 安倍正博
  • Organizer: American Society of Hematology 51st Annual Meeting and Exposition
  • Place of Presentation: New Orleans Convention Center
  • Year and Date: 2009-11-24
• [Presentation] Bone marrow microenvironment up-regulates Pim-2 expression in myeloma cells to enhance myeloma cell survival (2009)
  • Author(s): 安倍正博
  • Organizer: The IX International Meeting on Cancer lnduced Bone Diseases
  • Place of Presentation: Doubletree Hotel, Arlington, Virginia
  • Year and Date: 2009-10-27
• [Presentation] 内臓脂肪蓄積制御に関わる因子の臨床的検討 (2009)
  • Author(s): 粟飯原賢一
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 滋賀県(大津プリンスホテル)
  • Year and Date: 2009-10-01
• [Presentation] A new calcilytic compound, JTT-305, inhibits enhanced signaling by activating mutations of calcium-sensing receptor in autosomal dominant hypocalce mia (ADH) (2009)
  • Author(s): 遠藤逸朗
  • Organizer: American Society for Bone and Mineral Research31th Annual Meeting
  • Place of Presentation: Denver Convention Center
  • Year and Date: 2009-09-16
• [Presentation] 常染色体優性低Ca血症(ADH)に対するcalcilyticsの治療応用への可能性 (2009)
  • Author(s): 遠藤逸朗
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪市(大阪国際会議場)
  • Year and Date: 2009-07-23
• [Presentation] Influence of lipid profile on endothelial function in subjects with cardiovascular risk factors (2009)
  • Author(s): 粟飯原賢一
  • Organizer: 第41回日本動脈硬化学会総会
  • Place of Presentation: 下関(海峡メッセ下関)
  • Year and Date: 2009-07-17
• [Presentation] 微少重力や長期臥床による骨粗鬆症への挑戦 (2009)
  • Author(s): 松本俊夫
  • Organizer: 第46回日本リハビリテーション医学会学術集会(シンポジウム)
  • Place of Presentation: 静岡県コンベンションセンター
  • Year and Date: 2009-06-04
• [Presentation] 尿中アルブミンは内臓脂肪蓄積の強力な増悪因子である (2009)
  • Author(s): 粟飯原賢一
  • Organizer: 第82回日本内分泌学会総会
  • Place of Presentation: 群馬県(群馬県民会館)
  • Year and Date: 2009-04-24
• [Presentation] 多発性骨髄腫骨病変の形成機序の解明と治療法の開発 (2008)
  • Author(s): 安倍正博
  • Organizer: 第26回日本骨代謝学会学術集会(学術賞受賞講演)
  • Place of Presentation: 大阪(大阪国際会議場)
  • Year and Date: 2008-10-30
• [Presentation] 悪性腫瘍と骨病変 (2008)
  • Author(s): 松本俊夫
  • Organizer: 第53回日本口腔外科学会総会(特別講演)
  • Place of Presentation: 徳島県(アスティ徳島)
  • Year and Date: 2008-10-21
• [Presentation] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients-Proposal of diagnostic criteria using FGF23 measurement (2008)
  • Author(s): 遠藤逸朗
  • Organizer: ASBMR 2008
  • Place of Presentation: モントリオール
  • Year and Date: 2008-09-13
• [Presentation] Bone marrow stromal cells up-regulate M-CSF receptor in monocytes to disrupt dendritic cell differentiation while facilitating osteoclastogenesis in myeloma (2008)
  • Author(s): 安倍正博
  • Organizer: ASBMR 2008
  • Place of Presentation: モントリオール
  • Year and Date: 2008-09-13
• [Presentation] 骨髄腫骨病変に対する新規薬物療法の開発(シンポジウム) (2008)
  • Author(s): 安倍正博
  • Organizer: 第17回硬組織再生生物学会総会
  • Place of Presentation: 徳島(徳島文理大学国際会議場)
  • Year and Date: 2008-08-30
• [Presentation] 脂質代謝異常による左室拡張障害の臨床的検討 (2008)
  • Author(s): 粟飯原賢一
  • Organizer: 第40回日本動脈硬化学会総会
  • Place of Presentation: 筑波(筑波国際会議場)
  • Year and Date: 2008-07-11
• [Presentation] TACE up-regulation in monocytes by GM-CSF and IL-4 disrupts myeloma cell-induced osteoclastogenesis while inducing dendritic cell differentiation (2008)
  • Author(s): 安倍正博
  • Organizer: International Meeting on Cancer Induced Bone Disease (Invited speaker)
  • Place of Presentation: Scotland Heriot Watt University
  • Year and Date: 2008-07-02
• [Presentation] The active form of vitamin D, 1, 25 (OH) 2D3, prevents vascular remodeling and glucose intolerance in elderly individuals (2008)
  • Author(s): 粟飯原賢一
  • Organizer: Internat'l Society of Hypertension
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-16
• [Presentation] 骨粗鬆症診療の進歩 (2008)
  • Author(s): 松本俊夫
  • Organizer: 第81回日本整形外科学会総会(教育講演)
  • Place of Presentation: 札幌市(ホテルロイトン札幌)
  • Year and Date: 2008-05-23
• [Presentation] 骨カルシウム内分泌学の他領域との融合に向けた研究 (2008)
  • Author(s): 松本俊夫
  • Organizer: 第81回日本内分泌学会学術総会(学会賞受賞講演)
  • Place of Presentation: 青森県(青森市文化会館)
  • Year and Date: 2008-05-17