2010 Fiscal Year Final Research Report
Relationships among skeletal, adipose and vasclar regulatory system, and elucidation of pathogensis caused by disturbances of these systems
Project/Area Number |
20249050
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | The University of Tokushima |
Principal Investigator |
MATSUMOTO Toshio The University of Tokushima, 大学院・ヘルスバイオサエン研究部, 教授 (20157374)
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Co-Investigator(Kenkyū-buntansha) |
ABE Masahiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (80263812)
AIHARA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372711)
FUJINAKA Yuichi 徳島大学, 病院, 講師 (30432751)
ENDO Itsuro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10432759)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 内科 / 老化 / 多発性骨髄腫 / 骨粗鬆症 / 糖尿病 / 動脈硬化 |
Research Abstract |
IL-11 gene transcription is enhanced by mechanical stress to bone, and IL-11 stimulates osteoblast differentiation and bone formation via activation of canonical Wnt signaling. TGF-・inhibitor enhances osteoblast differentiation, and mature osteoblasts inhibit myeloma cell proliferation. Thus, TGF-・inhibition can become a new therapeutic approach against multiple myeloma. Pitavastatin ameliorates left ventricular diastolic function and microalbumiuria via suppression of oxidative stress. A thrombin inhibitor, heparin cofactor II, inhibits migration and proliferation of vascular smooth muscle cells, and protects against atherosclerotic changes.
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[Journal Article] The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells2011
Author(s)
Asano J, Nakano A, Oda A, Amou H, Hiasa M, Takeuchi K, Miki H, Nakamura S, Harada T, Fujii S, Kagawa K, Endo I, Yata K-I, Sakai A, Ozaki S, Matsumoto T, Abe M
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Journal Title
Peer Reviewed
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[Journal Article] Activation of Peroxisome Proliferator-activated Receptor alpha in Megakaryocytes Reduces Platelet-derived Growth Factor-BB in Platelets2011
Author(s)
Hashizume S, Akaike M, Azuma H, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Aihara KI, Abe M, Sata M, Matsumoto T
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Journal Title
J Atheroscler Thromb 18
Pages: 138-147
Peer Reviewed
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[Journal Article] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors.2011
Author(s)
Ise T, Aihara K, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T
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Journal Title
Hypertens Res 34
Pages: 225-231
Peer Reviewed
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[Journal Article] Delayed treatment with vitamin C and N-acetyl-L:-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib.2011
Author(s)
Nakano A, Abe M, Oda A, Amou H, Hiasa M, Nakamura S, Miki H, Harada T, Fujii S, Kagawa K, Takeuchi K, Watanabe T, Ozaki S, Matsumoto T
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Journal Title
Int J Hematol 93
Pages: 727-735
Peer Reviewed
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[Journal Article] Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.2010
Author(s)
Ikeda Y, Aihara K, Akaike M, Sato T, Ishikawa K, Ise T, Yagi S, Iwase T, Ueda Y, Yoshida S, Azuma H, Walsh K, Tamaki T, Kato S, Matsumoto T
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Journal Title
Mol Endocrinol 24
Pages: 1338-1348
Peer Reviewed
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[Journal Article] Validation of the Japanese Osteoporosis Quality of Life Questionnaire.2010
Author(s)
Kumamoto K, Nakamura T, Suzuki T, Gorai I, Fujinawa O, Ohta H, Shiraki M, Yoh K, Fujiwara S, Endo N, Matsumoto T
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Journal Title
J Bone Miner Metab 28
Pages: 1-7
Peer Reviewed
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[Journal Article] Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice.2010
Author(s)
Sumitomo-Ueda Y, Aihara K, Ise T, Yoshida S, Ikeda Y, Uemoto R, Yagi S, Iwase T, Ishikawa K, Hirata Y, Akaike M, Sata M, Kato S, Matsumoto T
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Journal Title
Hypertension 56
Pages: 430-436
Peer Reviewed
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[Journal Article] Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.2010
Author(s)
Takeuchi K, Abe M, Hiasa M, Oda A, Amou H, Kido S, Harada T, Tanaka O, Miki H, Nakamura S, Nakano A, Kagawa K, Yata K, Ozaki S, Matsumoto T
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Journal Title
Peer Reviewed
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[Journal Article] Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.2010
Author(s)
Yagi S, Akaike M, Aihara K, Ishikawa K, Iwase T, Ikeda Y, Soeki T, Yoshida S, Sumitomo-Ueda Y, Matsumoto T, Sata M
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Journal Title
Hypertension 55
Pages: 918-923
Peer Reviewed
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[Journal Article] Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.2010
Author(s)
Yagi S, Akaike M, Aihara K, Iwase T, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Kusunose K, Niki T, Yamaguchi K, Koshiba K, Hirata Y, Dagvasumberel M, Taketani Y, Tomita N, Yamada H, Soeki T, Wakatsuki T, Matsumoto T, Sata M
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Journal Title
J Atheroscler Thromb 17
Pages: 173-180
Peer Reviewed
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[Journal Article] Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function.2010
Author(s)
Yoshida S, Aihara K, Azuma H, Uemoto R, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Nishio S, Kawano H, Miki J, Yamada H, Hirata Y, Akaike M, Sata M, Matsumoto T
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Journal Title
Atherosclerosis 212
Pages: 310-315
Peer Reviewed
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[Journal Article] Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors.2009
Author(s)
Aihara K, Azuma H, Akaike M, Kurobe H, Takamori N, Ikeda Y, Sumitomo Y, Yoshida S, Yagi S, Iwase T, Ishikawa K, Sata M, Kitagawa T, Matsumoto T
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Journal Title
J Atheroscler Thromb 16
Pages: 127-134
Peer Reviewed
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[Journal Article] Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvediolo therapy is a novel predictor of long-term outcome in patients with chronic heart failure.2009
Author(s)
Fujimura M, Akaike M, Iwase T, Yoshida S, Sumitomo Y, Yagi S, Ikeda Y, Hashizume S, Aihara K, Nishiuchi T, Yasumura Y, Matsumoto T
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Journal Title
Acta Cardiol 64
Pages: 589-595
Peer Reviewed
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[Journal Article] A double-blinded head-to-head trial of minodronate and alendronate in women with postmenopausal osteoporosis.2009
Author(s)
Hagino H, Nishizawa Y, Sone T, Morii H, Taketani Y, Nakamura T, Itabashi A, Mizunuma H, Ohashi Y, Shiraki M, Minamide T, Matsumoto T
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Journal Title
Peer Reviewed
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[Journal Article] GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE).2009
Author(s)
Hiasa M, Abe M, Nakano A, Oda A, Amou H, Kido S, Takeuchi K, Kagawa K, Yata K, Hashimoto T, Ozaki S, Asaoka K, Tanaka E, Moriyama K, Matsumoto T
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Journal Title
Blood 114
Pages: 4517-4526
Peer Reviewed
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[Journal Article] Androgen-androgen receptor system protects against angiotensin II-inducedvascular remodeling.2009
Author(s)
Ikeda Y, Aihara K, Yoshida S, Sato T, Yagi S, Iwase T, Sumitomo Y, Ise T, Ishikawa K, Azuma H, Akaike M, Kato S, Matsumoto T
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Journal Title
Endocrinology 150
Pages: 2857-2864
Peer Reviewed
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[Journal Article] Valproic acid exerts anti-tumor as well as anti-angiogenic effects on myeloma.2009
Author(s)
Kitazoe K, Abe M, Hiasa M, Oda A, Amou H, Harada T, Nakano A, Takeuchi K, Hashimoto T, Ozaki S, Matsumoto T
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Journal Title
Int J Hematol 89
Pages: 45-57
Peer Reviewed
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[Journal Article] Marked improvement of platelet transfusion refractoriness after bortezomib therapy in multiple myeloma.2009
Author(s)
Miki H, Ozaki S, Tanaka O, Lee E, Takimoto T, Watanabe H, Fujii S, Nakamura S, Kagawa K, Takeuchi K, Yata K, Abe M, Kagami S, Matsumoto T
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Journal Title
Int J Hematol 89
Pages: 223-226
Peer Reviewed
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[Journal Article] Pinl down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.2009
Author(s)
Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T
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Journal Title
J Biol Chem 284
Pages: 6109-6115
Peer Reviewed
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[Journal Article] Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement.2008
Author(s)
Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T
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Journal Title
Peer Reviewed
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[Journal Article] Causes and differential diagnosis of hypocalcemia -Recommendation proposed by expert panel supported by Ministry of Health, Labour and Welfare, Japan-.2008
Author(s)
Fukumoto, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T
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Journal Title
Endocr J 55
Pages: 787-794
Peer Reviewed
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[Journal Article] Pitavastatin, an HMG-GoA Reductase Inhibitor, Exerts eNOS-independent Protective Actions against Angiotensin II-Induced Cardiovascular Remodeling and Renal Insufficiency.2008
Author(s)
Yagi S, Aihara K, Ikeda Y, Sumitomo Y, Iwase T, Ishikawa K, Azuma H, Akaike M, Matsumoto T
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Journal Title
Circ Res 102
Pages: 68-76
Peer Reviewed
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