2010 Fiscal Year Final Research Report
Liver transplantation with novel strategy using the engineered chimeric liver as alternative graft
| Project/Area Number |
20249058
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
UEMOTO Shinji Kyoto University, 医学研究科, 教授 (40252449)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Eiji 自治医科大学, 医学部, 客員教授 (00245044)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 移植外科学 / 肝臓移植 / キメラ肝臓 |
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| Research Abstract |
To solve the serious shortage of liver grafts, the feasibility of chimeric liver as an alternative liver graft has been investigated. The chimeric liver formed with rat hepatic parenchyma and mouse non-parenchyma was harvested from scaffold mouse and transplanted into rat recipient, followed by the immunosuppressive protocols. We have found, with appropriate immunosuppression, graft survival was significantly prolonged and graft tissues were maintained better. Moreover, we found its albumin production for 4 months. We have shown the possibility of the strategy using chimeric liver graft.
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