Study on the molecular diagnosis of metastasis and recurrence and molecular targeted therapy for intractable hepato-pancreatic cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 20249061
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ARII Shigeki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50151171)
• Co-Investigator(Kenkyū-buntansha): INAZAWA Jyouji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551) ; MIKI Yoshio 東京医科歯科大学, 難治疾患研究所, 教授 (10281594) ; TANAKA Shinji 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30253420)
• Project Period (FY): 2008 – 2011
• Keywords: 肝癌 / 膵癌 / DNAマイクロアレイ / microRNA / 幹細胞 / EpCAM / 酸化ストレス / 分子標的治療

Research Abstract

According to the DNA microarray analysis using clinical samples of hepatocellular carcinoma(HCC), aurora kinase B was identified as the only independent predictor of the lethal recurrence. Preclinical tests revealed the specific inhibitor of aurora kinase B was the promising agent to treat the aggressive HCC.
The distinct signature of gene expression closely related to the morphological progression in HCC. Especially, a stem cell marker EpCAM might play a critical role in the aggressiveness of confluent multinodular type of HCC.
Among the alterations of transport system in the nuclear microenvironment, we focused on the importin family using microarray analysis of HCC tissues. Importin alpha1 was identified as a molecule activated functionally in HCC cells, and its significance was also validated clinicopathologically.
The study showed that(i) tumor-specific hypermethylation-mediated silencing of miR-124 and miR-203 was a relatively frequent molecular event in primary HCCs and(ii) miR-124 and miR-203 exert cell growth-inhibitory effect with the downregulation of their potential targets, resulting in cell cycle arrest at the G1 S checkpoint and apoptosis, respectively.
We identified the downregulation of CYP1A2 in non-cancerous liver tissue as a predictive factor for recurrence of early-stage HCC. The significance of non-cancerous CYP1A2 was confirmed by validation study using the prospective multi-center cohort. GSEA revealed that close association of CYP1A2 was implicated with the oxidative stress pathways in liver tissue.
We used a fluorescence marker system for level of proteasome activity to identify pancreatic cancer cells with features of cancer stem cells(CSCs). We screened and identified a compound that is specifically toxic to the pancreatic CSCs.

Research Products

• [Journal Article] Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity (2012)
  • Author(s): Sakai S, Inamoto K, Liu Y, Tanaka S, Arii S, Taya M
  • Journal Title: Cancer Science Volume: 103(3) Pages: 549-554
  • Peer Reviewed
• [Journal Article] DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue (2012)
  • Author(s): Yasen M, Obulhasim G, Kajino K, Mogushi K, Mizushima H, Tanaka S, Tanaka H, Hino O, Arii S
  • Journal Title: International Journal of Oncology Volume: 40(3) Pages: 789-797
  • Peer Reviewed
• [Journal Article] Oxidative stress pathways in non-cancerous human liver tissue to predict hepatocellular carcinoma recurrence (2011)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Ban D, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Yamamoto M, Kokudo N, Takayama T, Kawasaki S, Sakamoto M, Arii S
  • Journal Title: a prospective multi-center study. Hepatology Volume: 54(4) Pages: 1273-1281
  • Peer Reviewed
• [Journal Article] Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies (2011)
  • Author(s): Tanaka S, Arii S
  • Journal Title: Journal of Gastroenterology Volume: 46 Pages: 289-296
  • Peer Reviewed
• [Journal Article] Gene expression signature of the gross morphology in hepatocellular carcinoma (2011)
  • Author(s): Murakata A, Tanaka S, Mogushi K, YasenM, Noguchi N, Kudo A, Nakamura N, ItoK, Miki Y, Inazawa J, Tanaka H, AriiS
  • Journal Title: Annals of Surgery Volume: 253(1) Pages: 94-100
  • Peer Reviewed
• [Journal Article] Importin-alpha1 as a novel prognostic target for hepatocellular carcinoma (2011)
  • Author(s): Yoshitake Y, Tanaka S, Mogushi K, Aihara A, Murakata A, Matsumura S, Mitsunori Y, Yasen M, Ban D, NoguchiN, Irie T, Kudo A, Nakamura N, TanakaH, Arii S
  • Journal Title: Annals of Surgical Oncology Volume: 18(7) Pages: 2093-2103
  • Peer Reviewed
• [Journal Article] Pancreatoduodenectomy after coronary artery bypass grafting using the right gastroepiploic artery (2011)
  • Author(s): Nakamura N, Irie T, Ochiai T, Kudo A, Itoh K, Tanaka S, Teramoto K, Arii S
  • Journal Title: Hepatogastroenterology Volume: 58(109) Pages: 1137-1141
  • Peer Reviewed
• [Journal Article] Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile (2011)
  • Author(s): Miyaguchi K, Fukuoka Y, Mizushima H, Yasen M, Nemoto S, Ishikawa T, UetakeH, Tanaka S, Sugihara K, Arii S, Tanaka H
  • Journal Title: Bioinformation Volume: 7(6) Pages: 280-284
  • Peer Reviewed
• [Journal Article] Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas (2010)
  • Author(s): Tanaka S, Mogushi K, Yasen M, NoguchiN, Kudo A, Nakamura N, Ito K, Miki Y, Inazawa J, Tanaka H, Arii S
  • Journal Title: Surgery Volume: 147 Pages: 405-414
  • Peer Reviewed
• [Journal Article] Novelmolecular-targeted therapy for hepatocellular carcinoma (2010)
  • Author(s): Tanaka S, Arii S
  • Journal Title: J Hepato-Biliary-Pancreat Surg Volume: 7(4) Pages: 1
• [Journal Article] Current status of molecularly targeted therapy for hepatocellular carcinoma : basic science (2010)
  • Author(s): Tanaka S, Arii S
  • Journal Title: Int J Clin Oncol Volume: 15(3) Pages: 235-41, 258-263
  • Peer Reviewed
• [Journal Article] The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma (2010)
  • Author(s): Aihara A, Tanaka S, Yasen M, MatsumuraS, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S
  • Journal Title: JHepatol Volume: 52 Pages: 63-71
  • Peer Reviewed
• [Journal Article] Surgical strategies for hepatocellular carcinoma with special reference to anatomical hepatic resection and intraoperative contrast-enhanced ultrasonography (2010)
  • Author(s): Arii S, Tanaka S, Mitsunori Y, Nakamura N, Kudo A, Noguchi N, Irie T
  • Journal Title: Oncology Volume: 78 Pages: 125-130
  • Peer Reviewed
• [Journal Article] miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma (2010)
  • Author(s): Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J
  • Journal Title: Carcinogenesis Volume: 31 Pages: 766-776
  • Peer Reviewed
• [Journal Article] Preservation solutions alter mrp2-dependent bile flow in cold ischemic rat livers (2010)
  • Author(s): Sui S, Kudo A, Suematsu M, Tanaka S, Nakamura N, Ito K, Arii S
  • Journal Title: J SurgRes Volume: 159 Pages: 572-581
  • Peer Reviewed
• [Journal Article] PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma (2010)
  • Author(s): Tsuji K, Yasui K, Gen Y, Endo M, DohiO, Zen K, Mitsuyoshi H, Minami M, ItohY, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T
  • Journal Title: Cancer Genet Cytogenet Volume: 198 Pages: 118-125
  • Peer Reviewed
• [Journal Article] Analogy between sphere forming ability and stemness of human hepatoma cells (2010)
  • Author(s): Uchida U, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie K, Kudo A, Nakamura N, Lai PB, Arii S
  • Journal Title: Oncol Rep Volume: 24 Pages: 1147-1151
  • Peer Reviewed
• [Journal Article] A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating Rho A in Huh-7 hepatocellular carcinoma cells (2009)
  • Author(s): Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyosi H, MinamiM, Itoh Y, Tanaka S, Taniwaki M, AriiS, Okanoue T, Yoshikawa T
  • Journal Title: Cancer Letter Volume: 275 Pages: 27-34
  • Peer Reviewed
• [Journal Article] ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry (2009)
  • Author(s): Zen K, Yasui K, Nakajima T, Zen Y, ZenK, Gen Y, Mitsuyosi H, Mimami M, Mitsufuji S, Tanaka S, Itoh Y, Nakanuma Y, Taniwaki M, Arii S, Okanoue T, Yoshikawa T
  • Journal Title: GenesChromosomes Cancer Volume: 48 Pages: 109-120
  • Peer Reviewed
• [Journal Article] Expression of Aurora B and their alternative variant forms in hepatrocellular carcinoma and the adjacent tissue (2009)
  • Author(s): Mahmut Y, Mizushima H, Mogushi K, Obulhasim G, Miyaguchi K, Inoue K, Nakahara I, Ohta T, Aihara A, TanakaS, Arii S, Tanaka H
  • Journal Title: Cancer Sci Volume: 100 Pages: 472-480
  • Peer Reviewed
• [Journal Article] Surgical contribution to recurrence-free survival in patients with macrovascular invasion-negative hepatocellular carcinoma (2009)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Kurokawa T, Nakamura N, Inazawa J, Tanaka H, Arii S
  • Journal Title: J Am Coll Surg Volume: 208 Pages: 368-374
  • Peer Reviewed
• [Journal Article] Infrequent amplification of JUN in hepatocellular carcinoma (2009)
  • Author(s): Endo M, Yasui K, Nakajima T, Gen Y, Tsuji K, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, TanakaS, Arii S, Okanoue T, Yoshikawa T
  • Journal Title: Anticancer Res Volume: 29 Pages: 4989-4994
  • Peer Reviewed
• [Journal Article] CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma (2008)
  • Author(s): Inagaki Y, Yasui K, Endo M, Nakajima T, Zen K, Tsuji K, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, Okanoue T
  • Journal Title: Cancer Genet Cytogenet Volume: 180 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Aurora kinase B is a predictive factor for aggressive recurrence of hepatocellular carcinoma after curative hepatectomy (2008)
  • Author(s): Tanaka S, Arii S, Yasen M, Mogusi K, Su N-T, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H
  • Journal Title: Brit J Surg Volume: 95 Pages: 61-619
  • Peer Reviewed
• [Journal Article] Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan (2008)
  • Author(s): Makuuchi M, Kokudo N, Arii S, Futagawa S, Kaneko S, Kawasaki S, Matsuyama Y, Okazaki M, Okita K, Omata M, Saida Y, Takayama T, Yamaoka Y
  • Journal Title: Hepatology Res Volume: 38 Pages: 37-51
  • Peer Reviewed
• [Journal Article] Activation of B-Myb by E2F1 in hepatocellular carcinoma (2008)
  • Author(s): Nakajima T, Yasui K, Keika Z, Inagaki Y, Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, AriiS, Inazawa J, Okanoue T
  • Journal Title: Hepatology Res Volume: 38 Pages: 886-895
  • Peer Reviewed
• [Journal Article] Vitamin K(2) suppresses malignancy of HuH 7 hepatoma cells via inhibition of conenexin 43 (2008)
  • Author(s): Kaneda M, Zhang D, Bhattacharjee R, Nakahama K, Arii S, Morita I
  • Journal Title: Cancer Lett Volume: 38 Pages: 761-772
  • Peer Reviewed
• [Journal Article] The Liver Cancer Study Group of Japan Comparison of the outcomes between an anatomical resection and a non-anatomical minor heoatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey (2008)
  • Author(s): Eguchi S, Kanematsu T, Arii S, Okazaki M, Okita K, Omata M, IkaiI, Kudo M, Kojiro M, Makuuchi M, Monden M, Matsuyama Y, Nakanuma Y, Takayasu K
  • Journal Title: Surgery Volume: 143 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Liver Cancer Study Group of Japan Surgical resection vs percutaneous ablation for hepatocellular carcinoma : A preliminary report of the Japanese nationwide survey (2008)
  • Author(s): Hasegawa K, Makuuchi M, TakayamaT, Kokudo N, Arii S, Okazaki M, Okita K, Omata M, Kudo M, Kojiro M, Nakanuma Y, Takayasu K, Monden M, Matsuyama Y, Ikai I
  • Journal Title: J Hepatology Volume: 49 Pages: 589-594
  • Peer Reviewed
• [Journal Article] Influence of risk factors for metabolic syndrome and non-alcoholic fatty liver disease on the progression and prognosis of hepatocellular carcinoma (2008)
  • Author(s): Takamatsu S, Noguchi N, Kudo A, Nakamura N, Kawamura T, Teramoto K, Igari T, Arii S
  • Journal Title: Hepatogastroenterology Volume: 55 Pages: 609-614
  • Peer Reviewed
• [Journal Article] 肝癌に対する各種治療法消化器癌の外科治療 (2008)
  • Author(s): 有井滋樹
  • Journal Title: 肝胆膵(上西紀夫、中尾昭公編) Volume: 2巻 Pages: 6-10
  • Peer Reviewed
• [Journal Article] 小肝細胞癌の治療消化器癌の外科治療 (2008)
  • Author(s): 有井滋樹
  • Journal Title: 肝胆膵(上西紀夫、中尾昭公編) Volume: 2巻 Pages: 23-26
  • Peer Reviewed
• [Journal Article] Current Organ Topics肝癌の診断・治療 (2008)
  • Author(s): 有井滋樹, 田中真二, 伊東浩次, 中村典明, 工藤篤, 野口典男
  • Journal Title: 最前線、癌と化学療法 Volume: 35(10) Pages: 1676-1680
  • Peer Reviewed
• [Journal Article] [肝移植Crossfire]肝細胞癌と肝移植Neoadjuvant治療とSalvage移植の意義 (2008)
  • Author(s): 田中真二, 野口典男, 平良薫, 工藤篤, 中村典明, 伊東浩次, 有井滋樹
  • Journal Title: 肝・胆・膵 Volume: 56(4)巻 Pages: 549-555
  • Peer Reviewed
• [Journal Article] [癌の転移形成のメカニズムと治療戦略]臨床検体を用いた転移形成遺伝子群の同定と機能解析による分子標的治療の開発 (2008)
  • Author(s): 田中真二, 有井滋樹
  • Journal Title: 癌の臨床 Volume: 54(3)巻 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents
  • Author(s): Adikrisna R, Tanaka S, Muramatsu S, Aihara A, Ban D, Ochiai T, Irie T, KudoA, Nakamura N, Yamaoka S, Arii S
  • Journal Title: Gastroenterology Volume: (in press)
• [Journal Article] Contrast-enhanced intraoperative ultrasound for hepatocellular carcinoma : high sensitivity of diagnosis and therapeutic impact
  • Author(s): Mitsunori Y, Tanaka S, Nakamura N, BanD, Irie T, Noguchi N, Kudo A, IijimaH, Arii SQ
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: (in press)
  • Peer Reviewed
• [Presentation] Asia-Pacific Symposium Angiogenesis and stemnesspotentials in hepatocellularcarcinoma (2011)
  • Author(s): Tanaka S, Arii S
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-10
• [Presentation] シンポジウム「進行肝細胞癌の治療戦略」進行肝細胞癌に対する集学的治療戦略と肝切除術の意義 (2011)
  • Author(s): 田中真二,藍原有弘,伴大輔,落合高〓,入江工,工藤篤,中村典明,有井滋樹
  • Organizer: 第73回日本臨床外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-17
• [Presentation] Symposium : Liver Pathology. Gene expression signature and the specific role of EpCAM stem cell marker in gross morphology of hepatocellular carcinoma (2011)
  • Author(s): Tanaka S, Murakata A, Mogushi K, Ogawa K, Muramatsu S, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yasen M, Tanaka H, Arii S
  • Organizer: 21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: 東京
  • Year and Date: 2011-11-10
• [Presentation] パネルディスカッション「消化器癌の悪性度・予後における分子診断」幹細胞性GSEA/パスウェイ解析に基づいた肝癌臨床への展開 (2011)
  • Author(s): 田中真二,茂櫛薫,有井滋樹
  • Organizer: 第9回日本消化器外科学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-24
• [Presentation] 高度進行肝癌に対する集学的治療戦略 (2011)
  • Author(s): 田中真二,伴大輔,入江工,野口典男,工藤篤,中村典明,有井滋樹
  • Organizer: 第15回日本肝臓学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-20
• [Presentation] 肝癌再発を予測するオミックス解析と分子標的治療への応用 (2011)
  • Author(s): 田中真二,藍原有弘,茂櫛薫,落合高〓,ヤセンマハムット,稲澤譲治,田中博,有井滋樹
  • Organizer: EpCAM, a molecular target associated with the gross morphology in hepatocellular carcinoma 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] ワークショップ「消化器癌に対する分子生物学の臨床応用」肝胆膵癌の包括的オミックス解析による臨床応用 (2011)
  • Author(s): 田中真二,松村聡,渡辺雄一郎,光法雄介,伴大輔,入江工,野口典男,工藤篤,中村典明,有井滋樹
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-15
• [Presentation] ワークショップ「がん幹細胞」肝癌の腫瘍形態と幹細胞マーカーの意義 (2011)
  • Author(s): 田中真二,村形綾乃,茂櫛薫,小川康介,伴大輔,入江工,野口典男,工藤篤,中村典明,田中博,有井滋樹
  • Organizer: 第15回日本がん分子標的治療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-24
• [Presentation] シンポジウム「進行肝癌に対する治療戦略と手術の実際」進行肝癌に対する治療方針と集学的治療の意義 (2011)
  • Author(s): 田中真二,松村聡,光法雄介,伴大輔,入江工,野口典男,工藤篤,中村典男,有井滋樹
  • Organizer: 第23回日本肝胆膵外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-10
• [Presentation] シンポジウム「テーラーメイド医療時代へ向けた肝癌治療」肝癌の臨床解析に基づく治療戦略 (2011)
  • Author(s): 田中真二,中村典明,有井滋樹
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-03
• [Presentation] 難治性癌の肝細胞性解析に基づく分子標的治療の開発と応用 (2011)
  • Author(s): 田中真二,村形綾乃,村松俊輔,アディクリスナラマ,茂櫛薫,伴大輔,入江工,野口典男,工藤篤,中村典明,中山恒,田中博,田賀哲也,有井滋樹
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-28
• [Presentation] Gene expression signature of the non-cancerous liver tissue associated with the early recurrence of hepatocellular carcinoma (2011)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Inazawa J, Tanaka H, Arii S
  • Organizer: 102nd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-03
• [Presentation] 口演・統合的アレイ解析によるDNA過剰メチル化を指標とした肝細胞癌の新規がん抑制遺伝子の探索 (2010)
  • Author(s): 松村聡,井本逸勢,稲澤譲治,有井滋樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-28
• [Presentation] シンポジウム・外科臨床に基づく肝癌分子標的の解析と臨床展開 (2010)
  • Author(s): 田中真二,村形綾乃,有井滋樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-28
• [Presentation] 口演・肝細胞癌の早期再発を予測する非癌部遺伝子発現プロファイル (2010)
  • Author(s): 茂櫛薫,田中真二, Mahmut Yasen,野口典男,入江工,工藤篤,中村典明,稲澤譲治,田中博,有井滋樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] ポスター・遺伝子発現解析に基づいて肝癌脈管浸潤関連遺伝子の探索と同定 (2010)
  • Author(s): Mahmut Yasen,水島洋,茂櫛薫, Obulhasim Gulanbar,田中真二,有井滋樹,田中博
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] ミニシンポジウム・肝胆膵癌の分子標的治療肝癌臨床検体のオミックス解析を基盤とする分子標的の同定と前臨床試験への展開 (2010)
  • Author(s): 田中真二,藍原有弘,伴大輔,野口典男,入江工,工藤篤,中村典明,有井滋樹
  • Organizer: 第22回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-27
• [Presentation] マイクロアレイ解析により肝癌再発、悪性度診断分子マーカーの構築と同定 (2010)
  • Author(s): Mahmut Yasen,水島洋,茂櫛薫, Gulanbar Obulhasim,田中真二,有井滋樹,田中博
  • Organizer: 第99日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] Gene expression signature of the non-cancerous liver tissue associated with the early recurrence of hepatocellular carcinoma (2010)
  • Author(s): Tanaka S, Mogushi K, Mahmut Y, Noguchi N, Irie T, Kudo A, Nakamura N, Inazawa J, Tanaka H, Arii S
  • Organizer: 101st AACR Annual Meeting2010
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2010-04-19
• [Presentation] Aurora Kinase B is a novel target for treatment of hepatocellular carcinoma (2010)
  • Author(s): Tanaka S, Aihara A, Mahmut Y, Mogushi K, Taira K, Kudo A, Nakamura N, Ito K, Imoto I, EishiY, Miki Y, Inazawa J, Tanaka H, Arii S
  • Organizer: AACR Annual Meeting 2008. 2010. 4. 19. Washington, DC, America
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-04-19
• [Presentation] ワークショップ・難治性肝細胞癌の分子標的Aurora kinase Bの同定と選択的阻害剤を用いた前臨床試験 (2010)
  • Author(s): 藍原有弘,田中真二, Mahmut Yasen,アディクリスナラマ,岡島千怜,村松俊輔,吉武健一郎,松村聡,光法雄介,村形綾乃,入江工,野口典男,工藤篤,中村典明,山崎繁,有井滋樹
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] サージカルフォーラム・肝細胞癌においてDNA過剰メチル化で制御されているがん抑制遺伝子の統合的アレイ (2010)
  • Author(s): 松村聡,井本逸勢,小崎健一,稲澤譲治,有井滋樹
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] サージカルフォーラム・肝細胞癌の新たなバイオマーカーImportinα1の解析 (2010)
  • Author(s): 吉武健一郎,田中真二,茂櫛薫,アディクリスナラマ,村松俊輔,松村聡,光法雄介,村形綾乃,入江工,野口典男,工藤篤,中村典明,田中博,有井滋樹
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] サージカルフォーラム・肝細胞癌肉眼形態における遺伝子発現パターンの相違とその臨床的意義 (2010)
  • Author(s): 村形綾乃,田中真二,茂櫛薫, MahmutYasen,入江工,野口典男,工藤篤,中村典明,田中博,有井滋樹
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] パネルディスカッション・外科臨床に基づいた難治性消化器癌の分子標的治療の開発 (2010)
  • Author(s): 田中真二,藍原有弘,野口典男,入江工,工藤篤,中村典明,有井滋樹
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] Aurora Kinase B pathway as a novel molecular target in invasive hepatocellular carcinoma (2009)
  • Author(s): Tanaka S, Mogushi K, Aihara A, YasenM, Noguchi N, Kudo A, Kurokawa T, Nakamura N, Miki Y, Inazawa J, TanakaH, Arii S
  • Organizer: AACR Annual Meeting 2009
  • Place of Presentation: Denver, CO, USA
  • Year and Date: 2009-04-20
• [Presentation] Development of Novel Molecular Target Therapy for HCC (2008)
  • Author(s): Arii S, Tanaka S
  • Organizer: 6^<th> International Meeting Hepatocellular Carcinoma : Eastern and Western Experien-ces Current Issues of Hepatocellular Carcinoma
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-12-08
• [Presentation] Aurora Kinase B Inhibitor is a novel molecularly targeting therapeutic for hepatocellular carcinoma (2008)
  • Author(s): Aihara A, Tanaka S, Arii S
  • Organizer: ILCA 2008 Annual Conference
  • Place of Presentation: Chicago, USA
  • Year and Date: 2008-09-05
• [Book] 肝細胞癌の早期診断:画像と分子マーカー (2012)
  • Author(s): 有井滋樹
  • Total Pages: 265
  • Publisher: 株式会社アークメディア