2011 Fiscal Year Final Research Report
Basic research on the integrated regulation of locomotive function
| Project/Area Number |
20249064
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Sakae 東京大学, 医学部・附属病院, 教授 (50282661)
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| Co-Investigator(Kenkyū-buntansha) |
HIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
OGATA Toru 国立身体障害者リハビリテーションセンター研究所, 運動機能系障害研究部, 室長 (00392192)
HAGA Nobuhiko 東京大学, 医学部附属病院, 教授 (80251263)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 骨 / 軟骨 / 筋 / 神経 / Bcl-2ファミリー |
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| Research Abstract |
"Locomotive organs "regulates the important function of animals, motor function, and include various tissues such as bone, cartilage, muscle and neuron. We here investigated the regulatory mechanism of locomotive organs by focusing on the role of Bcl-2 family proteins, which regulate the apoptosis of the cells.
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[Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-b through molecular interaction between Smad3 and Traf62011
Author(s)
Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, Hirose J, Omata Y, Yasuda H, Imumara T, Nakamura K, Tanaka S.
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Journal Title
J Bone Miner Res
Volume: 26(7)
Pages: 1447-1456
DOI
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[Journal Article] Hes1 functions downstream of growth factors to maintain oligodendeocyte lineage cells in the early progenitor stage2011
Author(s)
Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M.
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Journal Title
Neuroscience
Volume: 176
Pages: 132-141
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[Journal Article] Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin injection in Cbl-b-deficient mice2011
Author(s)
Kohno S, Ueji T, Abe T, Nakao R, Hirasaka K, Oarada M, Harada-Sukeno A, Ohno A, Higashibata A, Mukai R, Terao J, Okumura Y, Nikawa T.
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Journal Title
Muscle Nerve
Volume: 43(2)
Pages: 9-223
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[Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.2011
Author(s)
Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T.
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Journal Title
Biochem Biophys Res Commun
Volume: 407(1)
Pages: 8-213
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[Journal Article] Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis2010
Author(s)
Doi T, Miyazaki T, Nishino J, Tanaka S, Matsui T, Komiya A, Yamamoto S, Tokimura F, Mori T, Nishimura K, Katho N, Hasegawa J, Omata Y, Matsushita T, Thoma S.
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Journal Title
Mod Rheumatol
Volume: 20(6)
Pages: 573-579
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[Journal Article] Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone2010
Author(s)
Nagase Y, Iwasawa M, Akiyama T, Ogata N, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Masuda H, Bouillet P, Nakamura K, Tanaka S.
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Journal Title
Ann N Y Acad Sci
Volume: 1192(1)
Pages: 330-337
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[Journal Article] Negative regulation of bone-resorbing activity of osteoclasts by anti-apoptotic Bcl-xL protein2009
Author(s)
Iwasawa M, Miyazaki T, Nagase Y, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Nakamura T, Kato S, Henninghausen L, Nakamura K, Tanaka S.
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Journal Title
J Clin Invest
Volume: 119
Pages: 3149-3159
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[Journal Article] The anti-apoptotic molecule Bcl-2 regulates the differentiation, activation and survival of both osteoblasts and osteoclasts2009
Author(s)
Nagase Y, Iwasawa M, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Hirose J, Nakamura H, Miyamoto T, Bouillet P, Nakamura K, Tanaka S.
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Journal Title
J Biol Chem
Volume: 284(52)
Pages: 36659-36669
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[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading2009
Author(s)
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T.
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Journal Title
Mol Cell Biol
Volume: 29(17)
Pages: 811-4798
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