2010 Fiscal Year Final Research Report
Regulatory mechanisms of differentiation and mechano-response in the osteocyte linage.
| Project/Area Number |
20249081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAMOTO Teruko Tohoku University, 大学院・歯学研究科, 教授 (00127250)
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| Co-Investigator(Kenkyū-buntansha) |
出口 徹 東北大学, 大学院・歯学研究科, 准教授 (30346457)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨細胞 / 骨芽細胞 / メカニカルストレス / 三次元ネットワーク / 細胞骨格 / 原子間力顕微鏡 / カルシウム応答 |
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| Research Abstract |
We established an experimental system that apply the mechanical stimulus to a single osteocyte and an osteoblast using an atomic force microscope and we examined mechanically induced site-dependent calcium responses.The different responses to extracellular stimuli among osteoblasts, osteoid osteocytes and mature osteocytes might be related to the differences in their mechanical properties and focal adhesions.
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Research Products
(30 results)
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[Journal Article] Sox9 Expression during Fracture Repair.2011
Author(s)
Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, Uematsu S, Yoshida Y, Kamioka H, Takano-Yamamoto T, Takada K, Yamashiro T.
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Journal Title
Cells Tissues Organs. (in press)
Peer Reviewed
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[Journal Article] Runxl is involved in the fusion of the primary and the secondary palatal shelves.2009
Author(s)
Charoenchaikorn K, Yokomizo T, Rice DP, Honjo T, Matsuzaki K, Shintaku Y, Imai Y, Wakamatsu A, Takahashi S, Ito Y, Takano-Yamamoto T, Thesleff I, Yamamoto M, Yamashiro T.
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Journal Title
Dev Biol. 326(2) Epub 2008 Oct 29. Erratum
Pages: 392-402
Peer Reviewed
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[Journal Article] The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes.2008
Author(s)
Sugawara Y, Ando R, Kamioka H, Ishihara Y, Murshid SA, Hashimoto K, Kataoka N, Tsujioka K, Kajiya F, Yamashiro T, Takano- Yamamoto T.
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Journal Title
Peer Reviewed
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