2010 Fiscal Year Final Research Report
Regulatory mechanisms of differentiation and mechano-response in the osteocyte linage.
| Project/Area Number |
20249081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAMOTO Teruko Tohoku University, 大学院・歯学研究科, 教授 (00127250)
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| Co-Investigator(Kenkyū-buntansha) |
出口 徹 東北大学, 大学院・歯学研究科, 准教授 (30346457)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨細胞 / 骨芽細胞 / メカニカルストレス / 三次元ネットワーク / 細胞骨格 / 原子間力顕微鏡 / カルシウム応答 |
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| Research Abstract |
We established an experimental system that apply the mechanical stimulus to a single osteocyte and an osteoblast using an atomic force microscope and we examined mechanically induced site-dependent calcium responses.The different responses to extracellular stimuli among osteoblasts, osteoid osteocytes and mature osteocytes might be related to the differences in their mechanical properties and focal adhesions.
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Cells Tissues Organs. (in press)
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[Journal Article] The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes.2008
Author(s)
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Peer Reviewed
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