2010 Fiscal Year Final Research Report
Regulation of Gene Transcription Inferred From Transcription Factor Binding and Nucleosome Positioning
| Project/Area Number |
20300103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
KONO Hidetoshi Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究主幹 (40291918)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Atsushi 日本原子力研究開発機構, 量子ビーム応用研究部門・生体分子シミュレーショングループ, 研究副主幹 (10399420)
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| Project Period (FY) |
2008 – 2010
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| Keywords | バイオインフォマティクス / ヌクレオソーム / 転写 / 遺伝子発現 / 制御 |
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| Research Abstract |
Gene Regulation is controlled by binding of regulator proteins to DNA and positioning of nucleosome structures. We have developed a method that can predict nucleosome positions based on the physico-chemical properties of DNA sequences. The predicted distributions of nucleosome positions around transcription start sites of yeast genes indicate that transcription patterns of the genes can be classified into five groups. In addition, GC content was highly correlated with the distribution of nucleosomes.
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