2010 Fiscal Year Final Research Report
Roles of heparan sulfate endosulfatases in higher brain functions
Project/Area Number |
20300108
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | University of Tsukuba |
Principal Investigator |
MASU Masayuki University of Tsukuba, 大学院・人間総合科学研究科, 教授 (20243032)
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Co-Investigator(Kenkyū-buntansha) |
MASU Kazuko 筑波大学, 大学院・人間総合科学研究科, 講師 (50344883)
ARINAMI Tadao 筑波大学, 大学院・人間総合科学研究科, 教授 (10212648)
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Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医学研究所, 教授 (10301780)
IKEDA Kazutaka 東京都精神医学総合研究所, 研究員 (60281656)
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Project Period (FY) |
2008 – 2010
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Keywords | 脳・神経 / 糖鎖 / 遺伝子 / 遺伝学 |
Research Abstract |
The roles of heparan sulfate endosulfatases, Sulf1 and Sulf2, in higher brain functions were examined using their respective knockout mice and behavioral test battery. Sulf1 knockout mice showed abnormalities in some behavioral tests, whereas Sulf2 knockout mice shoed no behavioral abnormalities. Human SULF1 gene showed genetic association with bipolar disorders.
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Research Products
(33 results)
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[Journal Article] Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development.2011
Author(s)
Koike, S., Yutoh, Y., Keino-Masu, K., Noji, S., Masu, M., Ohuchi, H.
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Journal Title
Dev.Dyn. 240巻
Pages: 413-421
Peer Reviewed
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[Journal Article] Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia.2010
Author(s)
Syu, A., Ishiguro, H., Inada, T., Horiuchi, Y., Tanaka, S., Ishikawa, M., Arai, M., Itokawa, M., Niizato, K., Iritani, S., Ozaki, N., Takahashi, M., Kakita, A., Takahashi, H., Nawa, H., Keino-Masu, K., Arikawa-Hirasawa, E., Arinami, T.
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Journal Title
Neuropsychopharmacology 35巻
Pages: 1155-1164
Peer Reviewed
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[Journal Article] A SnoN-Ccd1 Pathway Promotes Axonal Morphogenesis in the Mammalian Brain.2009
Author(s)
Ikeuchi, Y., Stegmuller, J., Netherton, S., Anh Huynh, M., Masu, M., Frank, D., Bonni, S., Bonni, A.
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Journal Title
J.Neurosci. 29巻
Pages: 4312-4321
Peer Reviewed
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[Journal Article] Distinct Roles of Neuropilin 1 Signaling for Radial and Tangential Extension of Callosal Axons.2009
Author(s)
Hatanaka, Y., Matsumoto, T., Yanagawa, Y., Fujisawa, H., Murakami, F., Masu, M.
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Journal Title
J.Comp.Neurol. 514巻
Pages: 215-225
Peer Reviewed
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[Journal Article] Autotaxin/lysophospholipase D-mediated LPA Signaling is Required to Form Distinctive Large Lysosomes in the Visceral Endoderm Cells of the Mouse Yolk Sac.2009
Author(s)
Koike, S., Keino-Masu, K., Ohto, T., Sugiyama, F., Takahashi, S., Masu, M.
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Journal Title
J.Biol.Chem. 284巻
Pages: 33561-33570
Peer Reviewed
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[Presentation] Autotaxin is required for anterior neural ridge formation, midbrain-hindbrain boundary patterning, and cranial neural tube closure.2010
Author(s)
Tagiuchi, S.Koike, Y.Yutoh, Keino-Masu, K., S.Noji, Masu, M., H.Ohuchi.
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
Place of Presentation
神戸
Year and Date
20101207-20101210
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[Presentation] マウス胎児脳におけるヘパラン硫酸多様性の検出2010
Author(s)
岡田拓也、桝和子、長嶺聖史、國田智、高橋智、Arie Oosterhof, Toin van Kuppevelt、桝正幸
Organizer
第33回日本神経科学学会大会・第53回日本神経化学会大会・第20回日本神経回路学会大会
Place of Presentation
神戸
Year and Date
20100902-20100904
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[Presentation] Autotaxin-mediated Control of Actin Dynamics through Rho-ROCK-LIM kinase Pathway is Required for Endocytic Vesicle Fusion and Lysosome Biogenesis in Yolk Sac Visceral Endoderm Cells.2008
Author(s)
Koike, S., Keino-Masu, K., Ohto, T., Sugiyama, F., Takahashi, T., Masu, M.
Organizer
The 48th annual meeting of the American Society for Cell Biology.
Place of Presentation
San Francisco, California, USA
Year and Date
20081213-20081217
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