2010 Fiscal Year Final Research Report
Function of Fields in the Auditory Cortex
Project/Area Number |
20300112
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Kumamoto University |
Principal Investigator |
SONG Wen-Jie Kumamoto University, 大学院・生命科学研究部, 教授 (90216573)
|
Co-Investigator(Kenkyū-buntansha) |
KAZUYA Saitoh 熊本大学, 教育学部, 准教授 (20301997)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 神経科学 / 生理学 / 脳・神経 |
Research Abstract |
We have carried out optical imaging studies, behavioral studies, as well as electrophysiological studies to probe the function of auditory fields in guinea pigs. We found 1) focal activation of the primary auditory field at a single site can evoke an eyelid response conditioned with a pure tone, 2) there are spontaneous activity events in the primary field and some events exhibited a spatiotemporal pattern highly similar to the tone-evoked activity, and 3) frequency discrimination by the population activity of the primary fields outperforms behavioral frequency discrimination results. These results not only suggest a role of the primary auditory cortex in tone perception and frequency discrimination, but also have an impact on auditory prosthesis by cortical stimulation.
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Author(s)
Kazuya Yamagata, Takafumi Senoguchi, Meihong Lu, Makoto Takemoto, Fazlul Karim, Chisa Go, Yoshifumi Sato, Mitsutoki Hatta, Tatsuya Yoshizawa, Eiichi Araki, Junichi Miyazaki, Wen-Jie Song
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Journal Title
Biochem Biophys Res Comm. 407
Pages: 620-625
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Author(s)
Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y.
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Journal Title
J Biol Chem 286(5)
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Peer Reviewed
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