2010 Fiscal Year Final Research Report
Comprehensive analysis of protein tyrosine phosphatase receptor type O
| Project/Area Number |
20300113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SHINTANI Takafumi National Institute for Basic Biology, 統合神経生物学研究部門, 准教授 (10312208)
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| Project Period (FY) |
2008 – 2010
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| Keywords | チロシンホスファターゼ / チロシンキナーゼ / 視神経 / 投射 / 行動解析 |
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| Research Abstract |
In this study, we analyzed Ptpro-deficient mice. In the axonal projections from the retina to the brain, we could not find any differences between wild-type and Ptpro-deficient mice. On the other hand, in some behavioral tests, we detected a significant difference between wild-type and Ptpro-deficient mice. We also found that Ptpro regulates multiple RPTKs in collaboration with other members of the R3 PTP subfamily.
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