2010 Fiscal Year Final Research Report
Molecular Mechanisms for neuronal interactions during synapse formation
| Project/Area Number |
20300115
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
HAMA Chihiro The Institute of Physical and Chemical Research, 総合生命科学部, 教授 (50238052)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 軸索 / 嗅覚 / ショウジョウバエ / 突然変異 / Wnt5 / Drl / ヒストン |
|---|
| Research Abstract |
We have studied several mutants showing that the olfactory receptor neurons exhibit abnormal axonal projection or synaptic targeting in the first olfactory processing center in the brain. Among these, we have concentrated our attention on the mutants of Wnt5, Drl and Drl-2. All these molecules constitute Wnt5 signaling, each expressed in a distinct pattern, and regulate the distribution of glomeruli in the olfactory center. Notably, both Drl and Drl-2 can play opposing roles in Wnt5 signaling, depending on the cells where they are expressed. These findings suggest a new mechanism for Wnt5 signaling in the development of neural circuits.
|
-
-
[Journal Article] Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development.2009
Author(s)
Sakurai, M., Aoki, T., Yoshikawa, S., Santschi, L.A., Saito, H., Endo, K., Ishikawa, K., Kimura, K-i., Ito, K., Thomas, J.B., Hama, C.
-
Journal Title
The Journal of Neuroscience 29
Pages: 4972-4980
Peer Reviewed
-
-
-
-
