2010 Fiscal Year Final Research Report
Netrin-G/NGL interaction for integrating neuronal information
| Project/Area Number |
20300116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ITOHARA Shigeyoshi The Institute of Physical and Chemical Research, 行動遺伝学技術開発チーム, チームリーダー (60252524)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUKAWA Hiroshi 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, リサーチアソシエイト (20392128)
NISHIMURA Chiko 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 研究員 (10373341)
YAGUCHI Kunio 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 研究員 (60553641)
ZHANG Qi 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 研究員 (20525604)
IWASATO Takuji 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 副チームリーダー (00311332)
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| Project Period (FY) |
2008 – 2010
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| Keywords | netrin-G1 / netrin-G2 / NGL1 / NGL2 / 変異マウス / シナプス伝達 / 可塑性 / 認知機能 |
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| Research Abstract |
netrin-G1 and netrin-G2 are expressed on axons of distinct neuronal circuits and form functionally distinct subdomains on dendrites via interaction with their specific ligands, NGL-1 and NGL-2, at synapses. Electrophysiologic and behavioral studies on mice lacking either netrin-G1 or netrin-G2 revealed that netrin-G/NGL interaction had important roles for maintaining the integrity of synaptic function and plasticity. Moreover, we provided evidence that the differential expression patterns of duplicated netrin-G1 and netrin-G2 genes were acquired by "special subfunction partitioning".
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