2011 Fiscal Year Final Research Report
Mechanism of laminar formation of cerebral cortex and layer-specific neural circuits
| Project/Area Number |
20300119
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Satoshi 神戸大学, 大学院・医学研究科, 講師 (90244681)
KATSUYAMA Yu 神戸大学, 大学院・医学研究科, 助教 (10359862)
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| Project Period (FY) |
2008 – 2011
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| Keywords | リーリン / Dab1 / reeler / yotari / 大脳皮質 / 層形成 |
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| Research Abstract |
Previous studies have elucidated many genes that are expressed in specific layers of cortical layers. Among these genes we chose four genes, i. e., mSorLA, ROR-beta, ER81 and Tbr1 and studied phenotypes of cerebral neocortex of the reeler mouse. It has been long considered that the reeler cortex is cytoarchitectually reversed. We have demonstrated that compaction of neuronal components expressing each layer marker is affected in the reeler cortex, which resulted in intermingling of different cortical neurons and blurred cortical layers. The similar abnormalities were also recognized in the dorsal horn of the spinal cord, dorsal cochlear nucleus and cerebellar neocortex of the reeler mouse, suggesting Reelin is essential for compaction of neurons. In the reeler cortex, ROR-beta expressing neurons are not widely scattered, suggesting compaction of ROR-beta expressing neurons-is regulated by molecules other than Reelin protein. In the reeler olfactory bulb, the cytoarchitectural abnormality is also subtle, and therefore formation of this laminar structure is regulated by Reelin-independent molecules. In conclusion, we could not identified reversed laminar structures of the reeler cortex as repeatedly reported by many previous reports, and the reeler malformation is caused by the intriguing outcomes of several mechanisms relating to Reelin protein.
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Research Products
(40 results)
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[Journal Article] The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex2009
Author(s)
Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M
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Journal Title
Dev Biol
Volume: 331(2)
Pages: 140-51
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[Journal Article] Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh12009
Author(s)
Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M.
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Journal Title
Development
Volume: 136(12)
Pages: 2049-58
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[Journal Article] Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development2009
Author(s)
Watanabe Y, Inoue K, Okuyama-Yamamoto A, Nakai N, Nakatani J, Nibu KI, Sato N, Iiboshi Y, Yusa K, Kondoh G, Takeda J, Terashima T, Takumi T
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Journal Title
J Comp Neurol
Volume: 515(5)
Pages: 565-84
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[Journal Article] Draxin, a repulsive guidance protein for spinal cord and forebrain commissures2009
Author(s)
Islam SM, Shinmyo Y, Okafuji T, Su Y, Naser IB, Ahmed G, Zhang S, Chen S, Ohta K, Kiyonari H, Abe T, Tanaka S, Nishinakamura R, Terashima T, Kitamura T, Tanaka H
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Journal Title
Science
Volume: 323(5912)
Pages: 388-93
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[Presentation] 転写抑制因子RP58は大脳皮質の細胞分裂パターンとニューロン生存に必須である2009
Author(s)
岡戸晴生, 丸山千秋, 杉谷善信, 福田裕子, 石田礼子, 平井志伸, 三輪昭子, 高橋亜紀代, 青木克己, 持田慶司, 鈴木治, 本田岳夫, 仲嶋一範, 小川正晴, 寺島俊雄, 松田潤一郎, 川野仁, 葛西正孝
Organizer
第32回日本神経科学大会
Place of Presentation
名古屋
Year and Date
2009-09-16
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