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2011 Fiscal Year Final Research Report

Synaptic maturation and tagging between early and late long-term potentiation-induced synapses

Research Project

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Project/Area Number 20300128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

SHIOSAKA Sadao  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (90127233)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Shigetaka  旭川医科大学, 医学部, 教授 (20230740)
Co-Investigator(Renkei-kenkyūsha) ISHIKAWA Yasuyuki  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90346320)
TAMURA Hideki  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (80437516)
Project Period (FY) 2008 – 2011
Keywordsニューロプシン(KLK8) / 海馬シャーファー側枝 / 海馬CA1 / LTP / 受容体蛋白質 / NMDA受容体 / Synaptic tagging
Research Abstract

Accumulating evidence has suggested pivotal roles for neural proteases in cognitive functions. Among such proteases, neuropsin, a kallikrein gene-related(KLK) endoprotease, appears to have a significant plasticity function that has been analyzed primarily in the hippocampal Schaffer-collateral pathway. Enzymatically active neuropsin is necessary to establish the early phase of long-term potentiation(LTP). Associations between early and persistent-LTP synapses may be related to mammalian working memory and consequently integration in learning and memory(Ishikawa et al). We challenged and succeeded to obtaining specific substrate for protease neuropsin and found that neuregulin-1 is the most suitable native substrate for neuropsin(Tamura et al). Novel signaling pathway of neuropsin-neuregulin might be a significant in mammalian cognition.

  • Research Products

    (34 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (11 results) Presentation (21 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Neuropsin-a possible early phase synaptic mediator2011

    • Author(s)
      SHIOSAKA, S. & ISHIKAWA, Y
    • Journal Title

      J. Chem. Neuroanat

      Volume: 42 Pages: 24-29

  • [Journal Article] Neuropsin cleaves EphB2 in the amygdala to control anxiety2011

    • Author(s)
      ATTWOOD, B. K., BOURGOGNON, J. M., PATEL, S., MUCHA, M., SCHIAVON, E., SKRZYPIEC, A. E., YOUNG, K. W., SHIOSAKA, S., KOROSTYNSKI, M., PIECHOTA, M., PRZEWLOCKI, R. & PAWLAK, R
    • Journal Title

      Nature

      Volume: 473 Pages: 372-375

  • [Journal Article] Diversity of Neuropsin(Kallikrein8)-dependent Synaptic Associativity in the Hippocampal Pyramidal Neuron2011

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Journal Title

      Journal of Physiology[London]

      Volume: 589 Pages: 3559-3573

  • [Journal Article] Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin2010

    • Author(s)
      SHINGAKI, K., MATSUZAKI, S., TANIGUCHI, M., KUBO, T., FUJIWARA, T., KANAZAWA, S., YAMAMOTO, A., TAMURA, H., MAEDA, T., OOI, K., MATSUMOTO, K., SHIOSAKA, S. & TOHYAMA, M
    • Journal Title

      Br. J. Dermatol

      Volume: 163 Pages: 466-475

  • [Journal Article] Olig2-expressing progenitor cells preferentially differentiate into oligodendrocytes in cuprizone-induced demyelinated lesions2009

    • Author(s)
      ISLAM, M. S., TATSUMI, K., OKUDA, H., SHIOSAKA, S. & WANAKA, A
    • Journal Title

      Neuroc hem. Int

      Volume: 54 Pages: 192-198

  • [Journal Article] Acute stress increases neuropsin mRNA expression in the mouse hippocampus through the glucocorticoid pathway2008

    • Author(s)
      HARADA, A., SHIOSAKA, S., ISHIKAWA, Y. & KOMAI, S
    • Journal Title

      Neurosci. Lett

      Volume: 436 Pages: 273-277

  • [Journal Article] Increased anxiety-like behavior in neuropsin(kallikrein-related peptidase8) genedeficient mice2008

    • Author(s)
      HORII, Y., YAMASAKI, N., MIYAKAWA, T. & SHIOSAKA, S
    • Journal Title

      Behav. Neurosci

      Volume: 122 Pages: 498-504

  • [Journal Article] Neuropsin(KLK8)-dependent and-independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus2008

    • Author(s)
      ISHIKAWA, Y., HORII, Y., TAMURA, H. & SHIOSAKA, S
    • Journal Title

      J. Neurosci

      Volume: 28 Pages: 843-849

  • [Journal Article] Genetic variations of human neuropsin gene and psychiatric disorders : polymorphism screening and possible association with bipolar disorder and cognitive functions2008

    • Author(s)
      IZUMI, A., IIJIMA, Y., NOGUCHI, H., NUMAKAWA, T., OKADA, T., HORI, H., KATO, T., TATSUMI, M., KOSUGA, A., KAMIJIMA, K., ASADA, T., ARIMA, K., SAITOH, O., SHIOSAKA, S. & KUNUGI, H
    • Journal Title

      Neuropsychopharm

      Volume: 33 Pages: 3237-3245

  • [Journal Article] Integrated In vivo Neural Imaging and Interface CMOS Devices : Design, Packaging, and Implementation2008

    • Author(s)
      NG, D. C., NAKAGAWA, T., MIZUNO, T., TOKUDA, T., NUNOSHITA, M., TAMURA, H., ISHIKAWA, Y., SHIOSAKA, S. & OHTA, H
    • Journal Title

      IEEE Sensor J

      Volume: 8 Pages: 121-130

  • [Journal Article] One-chip sensing device(biomedical photonic LSI) enabled to assess hippocampal steep and gradual up-regulated proteolytic activities2008

    • Author(s)
      TAMURA, H., NG, D. C., TOKUDA, T., NAOKI, H., NAKAGAWA, T., MIZUNO, T., HATANAKA, Y., ISHIKAWA, Y., OHTA, J. & SHIOSAKA, S
    • Journal Title

      J. Neurosci. Meth

      Volume: 173 Pages: 114-120

  • [Presentation] Neuropsin(KLK8)シグナル系-精神疾患の新規治療戦略への期待2012

    • Author(s)
      塩坂貞夫
    • Organizer
      大阪神経科学研究会(ORIGIN)
    • Place of Presentation
      大阪
    • Year and Date
      20120300
  • [Presentation] 海馬におけるニューロプシン依存的シナプス連合性の解析2011

    • Author(s)
      石川保幸、田村英紀、塩坂貞夫
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      金沢
    • Year and Date
      20110000
  • [Presentation] 自由行動下マウスの海馬CA1におけるニューロプシン依存的シナプス可塑性2011

    • Author(s)
      山下春奈、石川保幸、塩坂貞夫
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      金沢
    • Year and Date
      20110000
  • [Presentation] マウス海馬におけるマトリックスメタロプロテアーゼ活性の組織学的解析2011

    • Author(s)
      鈴木春満、金河大、塩坂貞夫
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      金沢
    • Year and Date
      20110000
  • [Presentation] ニューロプシン・ニューレグリンシステムの脳内分布と機能2011

    • Author(s)
      河田美穂、田村英紀、塩坂貞夫
    • Organizer
      第87回日本解剖学会近畿支部学術集会
    • Place of Presentation
      兵庫
    • Year and Date
      20110000
  • [Presentation] 新奇環境はシナプス可塑性に関与するプロテアーゼ、ニューロプシン(klk8)の遺伝子発現を高める2011

    • Author(s)
      金河大、鈴木春満、畠中由美子、石川保幸、塩坂貞夫
    • Organizer
      第88回生理学会第116回解剖学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      20110000
  • [Presentation] Chemical LTP刺激によってシナプス膜に集積する分子のスクリーニング2011

    • Author(s)
      中村雪子、石川保幸、塩坂貞夫
    • Organizer
      第88回生理学会第116回解剖学会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      20110000
  • [Presentation] Novel environment increases plasticity-related protease neuropsin gene without change in tPA gene ISN-ESN2011

    • Author(s)
      KANAGAWA, D., ISHIKAWA, Y., & SHIOSAKA, S
    • Organizer
      23rd Biennial Meeting
    • Place of Presentation
      Athens, Greece
    • Year and Date
      20110000
  • [Presentation] Histological profile of synaptic matrix metalloproteinase activity in the mouse hippocampus2011

    • Author(s)
      SUZUKI, H., KANAGAWA, D., & SHIOSAKA, S.
    • Organizer
      23rd Biennial Meeting
    • Place of Presentation
      Athens, Greece
    • Year and Date
      20110000
  • [Presentation] Functional neuroimaging by using an implantable CMOS multimodal device in a freely-moving mouse2011

    • Author(s)
      Kobayashi, T., TAMURA, H. HATANAKA, Y., MOTOYAMA, M., NODA, T., SASAGAWA, K., TOKUDA, T., ISHIKAWA, Y., SHIOSAKA, S. OHTA, J.
    • Organizer
      Biomedical Circuits and Systems Conference(BioCAS)
    • Place of Presentation
      IEEE
    • Year and Date
      20110000
  • [Presentation] Diversity of neuropsin-dependent synaptic associativity2011

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      20110000
  • [Presentation] Neuropsin dependent synaptic tagging in mouse hippocampus2010

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20100000
  • [Presentation] 細胞外セリンプロテアーゼニューロプシンの基質探索2010

    • Author(s)
      田村英紀、濱口晴也、石川保幸、塩坂貞夫
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20100000
  • [Presentation] ニューロプシン依存的シナプスタギングの解析2010

    • Author(s)
      石川保幸、田村英紀、塩坂貞夫
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20100000
  • [Presentation] Neuropsin dependent compartment specific and process specific synaptic tagging2009

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20090000
  • [Presentation] Neuropsin dependent compartment specific and process specific synaptic tagging2009

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20090000
  • [Presentation] Real-time in vivo molecular quantification for freely-moving mouse's hippocampus2009

    • Author(s)
      TAMURA, H. HATANAKA, Y., MINAMI, H., TAGAWA, A., NODA, T., SASAGAWA, K., TOKUDA, T., OHTA, J., ISHIKAWA, Y., SHIOSAKA, S
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20090000
  • [Presentation] Environmental enrichment enhances neuropsin mRNA in the hippocampus2009

    • Author(s)
      KANAGAWA, D., ISHIKAWA, Y., & SHIOSAKA, S
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      20090000
  • [Presentation] Neuropsin(KLK8) dependent compartment specific and process specific synaptic tagging2009

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保、群馬
    • Year and Date
      20090000
  • [Presentation] Neuropsin-dependent and-independent synaptic tagging2008

    • Author(s)
      ISHIKAWA, Y., TAMURA, H. & SHIOSAKA, S
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      20080000
  • [Presentation] Neuropsin依存的・非依存的シナプスタギング2008

    • Author(s)
      石川保幸、堀井洋一郎、田村英紀、塩坂貞夫
    • Organizer
      第31回日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      20080000
  • [Remarks] ホームページ

    • URL

      http://bsw3.naist.jp/courses/courses205.html

  • [Patent(Industrial Property Rights)] ニューレグリン-1(Neuregulin-1)部分ペプチド2011

    • Inventor(s)
      塩坂貞夫、田村英紀
    • Industrial Property Rights Holder
      奈良先端科学技術大学院大学
    • Industrial Property Number
      特許、特願2011-259056
    • Filing Date
      2011-11-28

URL: 

Published: 2013-07-31   Modified: 2016-01-14  

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