2011 Fiscal Year Final Research Report
Roles of a neural activity-regulated protocadherin in spine formation
| Project/Area Number |
20300135
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2008-2010) |
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Principal Investigator |
YAMAGATA Kanato 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー (20263262)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Hiroko 財団法人東京都医学総合研究所, 基盤技術研究センター, 基盤技術研究職員 (40162870)
TANAKA Hidekazu 大阪大学, 医学系研究科, 准教授 (70273638)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 樹状突起 / スパイン / プロトカドヘリン / 神経活動 |
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| Research Abstract |
Arcadlin is an activity-regulated membrane protein that reduces excitatory synpatic number by activating the TAO2-MEK3-p38 MAPK signaling and inducing N-cadherin endocytosis. We have analyzed the physiological and pathological roles, regulatory mechanism, and knockout mice of arcadlin. As a result, we found 1) the arcadlin-N-cadherin complex associates with GluR2 and accelerates its endocytosis, 2) the internalization of arcadlin is mediated by endophilin-3 and arc, 3) arcadlin expression is regulated by COX-2, 4) arcadlin knockout mice show abnormal behavior, and 5) TAO2 mutation may cause developmental disorder.
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