2010 Fiscal Year Final Research Report
Organization and basic functional mechanism of cerebellar modules
| Project/Area Number |
20300137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUGIHARA Izumi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60187656)
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| Research Collaborator |
藤田 啓史 東京医科歯科大学, 大学院・医歯学総合研究科, 大学院博士課程学生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小脳 / 後索核 / プルキンエ細胞 / アルドラーゼC / マーモセット / 苔状線維 / ラット / 神経解剖学 |
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| Research Abstract |
The cerebellar module is organized by the molecular expression pattern and input-output axonal connections of Purkinje cells, climbing fibers and mossy fibers. We related axonal connections of Purkinje cells and mossy fiber axons that originate from the dorsal column nuclei to the aldolase C expression pattern. Combining the results with our previous findings on the climbing fiber projection pattern, we clarified the organization of cerebellar modules, and show how cerebellar input and output functions are correlated topographically. Furthermore, we have shown similarity of the cerebellar modular organization between rodents and primates by analyzing the marmoset cerebellum in addition to the rat cerebellum.
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[Journal Article] Projection of reconstructed single Purkinje cell axons in relation to the cortical and nuclear aldolase C compartments of the rat cerebellum.2009
Author(s)
Sugihara, I., Fujita, H., Na, J., Quy, P.N., Li, B.Y., Ikeda, D.
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Journal Title
J.Comp.Neurol. 512
Pages: 282-304
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[Journal Article] BCL-2 counteracts Doppel-induced apoptosis of prion-protein-deficient Purkinje cells in the Ngsk Prnp^<0/0> mouse.2008
Author(s)
Heitz, S., Gautheron, V., Lutz, Y., Rodeau, J.L., Zanjani, H.S., Sugihara, I., Bombarde, G., Richard, F., Fuchs, J.P., Vogel, M.W., Mariani, J., Bailly, Y.
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Journal Title
Dev.Neurobiol. 68
Pages: 332-348
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