Positive and negative reward coding by serotonin, acetylcholine, and dopamine network.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20300139
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kansai Medical University
• Principal Investigator: NAKAMURA Kae Kansai Medical University, 医学部, 教授 (40454607)
• Project Period (FY): 2008 – 2011
• Keywords: モノアミン神経伝達物質 / セロトニン / アセチルコリン / ドパミン / 報酬 / 嫌悪

Research Abstract

(1)報酬に基づく強化学習の神経生理学的研究は、自律的に行動するロボットの開発、教育への応用などに強力なインパクトを与える。強化学習理論では予測される報酬と実際に得られた報酬の差(報酬予測誤差)の計算過程が実験的、理論的に最も重要な問題の一つである。報酬予測誤差をコードするとされるドパミン細胞にはアセチルコリン細胞がある脚橋被蓋核(PPTN)とセロトニン細胞がある背側縫線核(DRN)の投射がある。これらが単一神経細胞レベルでどのような報酬情報を計算しているかを調べることを目的とした。
(2)高い時間解像度の神経活動の計測、行動変化との関連の解析、すでに確立されている神経回路モデルとの関連という条件を満たす動物モデルとして、眼球運動課題を行っている霊長類を用いた。PPTNは小林康、DRNは中村加枝が主に解析を行った。

Research Products

• [Journal Article] Serotonin and dopamine : Unifying affective, activational, and decision functions. (2011)
  • Author(s): Cools, R., Nakamura, K., Daw, N.D.
  • Journal Title: Neuropsychopharmacology 36 Pages: 98-113
  • Peer Reviewed
• [Journal Article] Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata). (2010)
  • Author(s): Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Takashi, Y., Nakamura, K., Tsubura, A.
  • Journal Title: Toxicologic Pathology 38(7) Pages: 1058-1063
  • Peer Reviewed
• [Journal Article] Coding of task reward value in the dorsal raphe nucleus. (2010)
  • Author(s): Bromberg-Martin,E.S., Hikosaka.O., Nakamura, K.
  • Journal Title: The Journal of Neuroscience 30(18) Pages: 6262-6272
  • Peer Reviewed
• [Journal Article] Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks. (2009)
  • Author(s): Ken-ichi Okada, Yasushi Kobayashi
  • Journal Title: European Journal of Neuroscience 30 Pages: 2211-2223
  • Peer Reviewed
• [Journal Article] Reward processing of the basal ganglia : Reward function of Pedunculopontine tegmental nucleus. (2009)
  • Author(s): Yasushi Kobayashi, Ken-ichi Okada
  • Journal Title: Brain and Nerve神経研究の進歩 61(4) Pages: 397-404
  • Peer Reviewed
• [Journal Article] Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards. (2009)
  • Author(s): Ken-ichi Okada, Keisuke Toyama, Yuka Inoue, Tadashi Isa, Yasushi Kobayashi
  • Journal Title: The Journal of Neuroscience 29 Pages: 4858-4870
  • Peer Reviewed
• [Presentation] Context dependent firing regularity of pedunculopontine tegmental nucleus of behaving monkeys. (2010)
  • Author(s): Ken-ichi Okada, Yasushi Kobayashi
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
  • Year and Date: 2010-11-16
• [Presentation] Positive and negative reward value coding in the primate lateral hypothalamus. (2010)
  • Author(s): Noritake, A., Nakamura, K.
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2010-11-15
• [Presentation] Neural processing of appetitive and aversive stimuli in the primate dorsal raphe nucleus. (2010)
  • Author(s): Hayashi, K., Nakao, K., Okada, K., Kobayashi, Y., Nakamura, K.
  • Organizer: Society for Neuroscience Meeting
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2010-11-15
• [Presentation] Positive and negative value coding in the primate dorsal raphe nucleus. (2009)
  • Author(s): Nakamura, K., Kobayashi, Y., Okada, O., Noritake, A., Matsuzaki, R., Nakao, K.
  • Organizer: Society for Neuroscience
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2009-10-20
• [Presentation] Analyses of the time course of neuronal activity of the pedunculopontine tegmental nucleus in monkeys for reward conditioned saccade task. (2009)
  • Author(s): Okada K, Kobayashi Y
  • Organizer: Society for Neuroscience
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2009-10-20
• [Presentation] Effects of relative and absolute magnitudes of reward on dorsal raphe neuronal activity in monkeys. (2008)
  • Author(s): Nakamura, K., Matsumoto, M., Hikosaka, O.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Walter E.Washington Convention Center, Washington, DC., USA
  • Year and Date: 2008-11-15
• [Presentation] Neural correlates of task performance of the visually guided saccade tasks in the primate pedunculopontine tegmental nucleus. (2008)
  • Author(s): Ken-ichi Okada, Yasushi Kobayashi
  • Organizer: Society for Neuroscience
  • Place of Presentation: Walter E.Washington Convention Center, Washington, DC., USA
  • Year and Date: 2008-11-15
• [Book] Advances in Reinforcement Learning. Chapter Title : Reward prediction error computation in the pedunculopontine tegmental nucleus neurons (2011)
  • Author(s): Yasushi Kobayashi, Ken-ichi Okada
  • Total Pages: 157-180
  • Publisher: Publisher Open Access Publisher INTECH
• [Remarks]
  • URL: http://www.kmu.ac.jp/depts/intro/physiol
• [Remarks]
  • URL: http://www7.bpe.es.osaka-u.ac.jp/~yasushi/gyoseki.htm