Function of spinal reflex circuit for regulating volitional movement.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20300140
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Center of Neurology and Psychiatry (2009-2010); National Institute for Physiological Sciences (2008)
• Principal Investigator: SEKI Kazuhiko 独立行政法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 部長 (00226630)
• Project Period (FY): 2008 – 2010
• Keywords: 反射 / 脊髄 / 随意運動 / 霊長類 / 電機生理

Research Abstract

By recording the activity of first-order spinal interneuron from primary afferents, we found that 1) they could be used to the automatic augmentation of voluntary muscle force, 2) afferent input to them were facilitated during static phase of task, and 3) reafference signal was strong enough to drive these interneurons.

Research Products

• [Journal Article] Spinal interneurons facilitate coactivation of hand muscles during a precision grip task in monkeys. (2010)
  • Author(s): Takei T, Seki K
  • Journal Title: The Journal of Neuroscience 30(50) Pages: 17041-50
  • Peer Reviewed
• [Journal Article] Task-dependent modulation of primary afferent depolarization in cervical spinal cord of monkeys performing an instructed delay task (2009)
  • Author(s): Seki K., Perlmutter S.I., Fetz E.E.
  • Journal Title: J.Neurophysiol 102 Pages: 85-99
  • Peer Reviewed
• [Journal Article] Spinomuscular coherence in monkeys performing a precision grip task (2008)
  • Author(s): Takei T., Seki K.
  • Journal Title: J.Neurophysiol 99(4) Pages: 2012-20
  • Peer Reviewed
• [Presentation] Modulation of sensory responses at spinal and cortical levels during preparation and execution of voluntary movement (2010)
  • Author(s): Seki K, E.E.Fetz
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2010-11-15
• [Presentation] How motion is encoded by sensory afferent ensembles in monkeys? (2010)
  • Author(s): Umeda T, Sakatani T, Yamashita O, Saitoh M, Morimoto J, Seki K, Kawato M, Isa T
  • Organizer: The 40th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2010-11-14
• [Presentation] 随意運動の制御における脊髄の役割:反射や歩行を越えて (2010)
  • Author(s): 関和彦
  • Organizer: 第176回つくばブレインサイエンス・セミナー
  • Place of Presentation: 筑波大学
  • Year and Date: 2010-10-12
• [Presentation] 随意運動と脊髄機能 (2010)
  • Author(s): 関和彦
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉商科大学
  • Year and Date: 2010-09-17
• [Presentation] 随意運動の制御における脊髄ニューロン系の役割とその臨床的意義 (2010)
  • Author(s): 関和彦
  • Organizer: 第87回日本生理学会大
  • Place of Presentation: いわて県民情報交流センター
  • Year and Date: 2010-05-19
• [Presentation] Spinomuscular coherence in monkey performing a precision grip task. (2009)
  • Author(s): Takei T, Seki K
  • Organizer: The 3rd International Symposium on Mobiligence
  • Place of Presentation: Awaji, Hyogo
  • Year and Date: 2009-11-20
• [Presentation] Spinal interneurons : A new role for controlling voluntary movements. (2009)
  • Author(s): 関和彦
  • Organizer: International Symposium, New Perspectives on Neural Mechanisms of Cognition and Action
  • Place of Presentation: Tamagawa University, Machida
  • Year and Date: 2009-11-13
• [Presentation] Post-spike effects of spinal interneurons on hand muscles in monkeys performing a precision grip. (2009)
  • Author(s): Takei T, Seki K
  • Organizer: The 39th annual meeting of the Society for the Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] A new role of spinal interneuronal networks for controlling volitional movement. (2009)
  • Author(s): 関和彦
  • Organizer: The 19th Society for the neural control of movement
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2009-05-01
• [Remarks] ホームページ等
  • URL: http://www.ncnp.go.jp/nin/guide/r_model/index.html