Experimental evidence of in situ capture of endothelial progenitor cells on luminal surface of artificial grafts in bloodstream on porcein model.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20300171
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kanazawa Institute of Technology
• Principal Investigator: MATSUDA Takehisa Kanazawa Institute of Technology, ゲノム生物工学研究所, 教授 (60142189)
• Co-Investigator(Kenkyū-buntansha): WATANABE Go 金沢大学, 医学(系)研究科(研究院), 教授 (60242492) ; OOTAKE Hiroshi 金沢大学, 医学(系)研究科(研究院), 特任教授 (60283131)
• Project Period (FY): 2008 – 2010
• Keywords: 生体材料 / 細胞組織 / 人工血管 / 生体力学 / 動物実験

Research Abstract

This study aims at in situ capture of endothelial progenitor cells (EPCs) on blood-contacting surfaces of cardiovascular devices in bloodstream. Among various cell surface receptor/legend pairs, only surface-bound VEGF/VEGF receptor pair induced adhesion, proliferation, and differentiation of EPCs in vitro. VEGF-bound stents and artificial grafts generated EPC adhesion and colonization, followed by endothelialization on porcein model. Thus, our prototype surface architecture to propose new concept of providing nonthrambogenic potential on blood-contacting devices.