2010 Fiscal Year Final Research Report
Surface modification of poly(L-lactic acid) nerve conduits with oligo(D-lactic acid)?bioactive-peptide conjugates
| Project/Area Number |
20300172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YAMAOKA Tetsuji National Cardiovascular Center Research Institute, 生体医工学部, 部長 (50243126)
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| Co-Investigator(Kenkyū-buntansha) |
HAMARA Atsushi (独)国立循環器病研究センター研究所, 生体医工学部, 研究員 (80416221)
MURASE Tsuyoshi 大阪大学, 大学院・医学研究科, 助教 (50335361)
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| Co-Investigator(Renkei-kenkyūsha) |
MURASE Tsuyoshi 大阪大学, 大学院・医学研究科, 助教 (50335361)
TANAKA Hiroyuki 大阪大学, 大学院・医学研究科, 医員 (00432542)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医工学材料 |
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| Research Abstract |
One of the attractive alternatives to the common therapeutic technique for autologous nerve grafting is the use of artificial nerve conduit. Poly (L-lactic acid) (PLLA) is widely used as a substrate for artificial nerve conduit because it is readily biodegradable. In the present project, we developed a PLLA nanofibrous nerve conduit, modified with a conjugate of oligo (D-lactic acid) (ODLA) and the neurite outgrowth, thereby promoting peptide such as IKVAV or AG73 to improve the nerve regeneration. PLA/ODLA-peptide modified nanofibrous conduit was fabricated by electrospinning and then transplanted at the 10 mm gap of rat sciatic nerve. After six months, electrophysiological evaluation revealed that it achieved better functional reinnervation than the silicone conduits or unmodified PLLA nanofibrous conduits.
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[Journal Article] Scaffolds from electrospun polyhydroxyalkanoate copolymers : Fabrication, characterization, bioabsorption and tissue response.2008
Author(s)
T.H.Ying, D.Ishii, A.Mahara, S.Murakami, T.Yamaoka, K.Sudesh, R.Samian, M.Fujita, M.Maeda, T.Iwata.
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Journal Title
Biomaterials 29
Pages: 1307-1317
Peer Reviewed
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