Basic research for renal rehabilitation : Clarification of mechanism of cardiovascular disease prevention

2010 Fiscal Year Final Research Report

• Project/Area Number: 20300184
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: KOHZUKI Masahiro 東北大学, 大学院・医学系研究科, 教授 (70234698)
• Co-Investigator(Kenkyū-buntansha): KANAZAWA Masayuki 東北大学, 大学院・医学系研究科, 非常勤講 (60282050) ; ITO Osamu 東北大学, 大学院・医学系研究科, 准教授 (00361072)
• Project Period (FY): 2008 – 2010
• Keywords: リハビリテーション医学

Research Abstract

In rats with chronic renal faikure, chronic exercise improved insulin sensitivity. The combination therapy with chronic exercise, angiotensin II receptor blocker and branched chain-amino acids improved blood pressure, renal protection, and capillary density and type I muscle fiber type in skeletal muscles. The combination therapy with chronic exercise and N + L type calcium channel blocker, cilnidipine improved blood pressure, renal protection and insulin sensitivity. These effects of chronic exercise and cilnidipine may be mediated by an inhibition of sympathetic nervous system.

Research Products

• [Journal Article] Endogenous hydrogen peroxide up regulates the expression of nitric oxide synthases in the kidney of spontaneously hypertensive rats (2011)
  • Author(s): Cao P, Ito O, Guo Q, Ito D, Muroya Y, Rong R, Mori T, Ito S, Kohzuki M
  • Journal Title: J Hypertens Volume: 29 Pages: 1167-1174
  • Peer Reviewed
• [Journal Article] Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats (2010)
  • Author(s): Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K
  • Journal Title: Peptides Volume: 31 Pages: 1920-5
  • Peer Reviewed
• [Journal Article] Expression of adrenomedullin 2/intermedin, a possible Reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure (2010)
  • Author(s): Hirose T, Totsune K, Mori N, Mori T, Morimoto R, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
  • Journal Title: Am J Physiol Renal Physiol Volume: 299 Pages: F128-34
  • Peer Reviewed
• [Journal Article] Increased expression of (prorenin receptor in the remnant kidneys of 5/6 nephrectomized rats (2010)
  • Author(s): Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, Kawamura T, Metoki H, Asayama K, Kikuya M, Ohkubo T, Kohzuki M, Takahashi K, Imai Y
  • Journal Title: Regul Pept Volume: 159 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Atorvastatin up regulates the expression of nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats (2010)
  • Author(s): Ito D, Ito O, Mori N, Muroya Y, Cao P, Takashima K, Kanazawa M, Kohzuki M
  • Journal Title: J Hypertens Volume: 28 Pages: 2278-2288
  • Peer Reviewed
• [Journal Article] Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats (2010)
  • Author(s): Guo Q, Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M, Kohzuki M
  • Journal Title: Clin Exp Hypertens Volume: 32 Pages: 1-8
  • Peer Reviewed
• [Journal Article] The renin-angiotensin system, adrenomedullins and urotensin II in the kidney : possible renoprotection via the kidney peptide systems (2009)
  • Author(s): Takahashi K, Hirose T, Mori N, Morimoto R, Kohzuki M, Imai Y, Totsune K
  • Journal Title: Peptides Volume: 30 Pages: 1575-85
  • Peer Reviewed
• [Journal Article] Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats : comparison with endothelin-1 (2009)
  • Author(s): Hirose T, Takahashi K, Mori N, Nakayama T, Kikuya M, Ohkubo T, Kohzuki M, Totsune K, Imai Y
  • Journal Title: Peptides Volume: 30 Pages: 1124-9
  • Peer Reviewed
• [Journal Article] Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation (2009)
  • Author(s): Lu H, Kanazawa M, Ishida A, Tufescu A, Sasaki Y, Ito O, Kurosawa H, Sato T, Ootaka T, Kohzuki M
  • Journal Title: Am J Hypertens Volume: 22 Pages: 1101-1106
  • Peer Reviewed
• [Journal Article] Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure (2009)
  • Author(s): Mori N, Hirose T, Nakayama T, Ito O, Kanazawa M, Imai Y, Kohzuki M, Takahashi K, Totsune K
  • Journal Title: Peptides Volume: 30 Pages: 400-408
  • Peer Reviewed
• [Journal Article] Disability prevention of cardiovascular and chronic kidney diseases : Effect of a combination therapy with exercise training and superoxide dismutase mimetic on blood pressure and nitric oxide synthase in spontaneously hypertensive rats (2009)
  • Author(s): Cao P, Ito O, Guo Q, Chang Y, Ito D, Muroya Y, Takashima K, Kanazawa M, Kohzuki M
  • Journal Title: Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine Volume: 13-14
• [Journal Article] Disability prevention of metabolic syndrome : Effects of exercise training on steatosis and fatty acid metabolisms in the liver of Zucker fatty rats (2009)
  • Author(s): Chang Y, Ito O, Cao P, Tan L, Takashima K, Muroya Y, Ito D, Kanazawa M, Kohzuki M
  • Journal Title: Proceedings of the 5th World Congress of the International Society of Physical and Rehabilitation Medicine Pages: 18-19
• [Journal Article] 厚生労働省循環器病研究委託費(15指-2)「わが国における心疾患リハビリテーションの実態調査と普及促進に関する研究」班 (2009)
  • Author(s): 上月正博, 齋藤宗靖, 岩坂壽二, 代田浩之, 上嶋健治, 牧田茂, 安達仁, 横井宏佳, 大宮一人, 三河内弘, 横山広行, 後藤葉一
  • Journal Title: わが国における心臓リハビリテーションの採算性多施設調査結果 Volume: 4 Pages: 269-275
  • Peer Reviewed
• [Journal Article] 高血圧自然発症ラットの腎Rho-キナーゼへのAtorvastatinの効果 (2009)
  • Author(s): 伊藤大亮, 伊藤修, 曹鵬宇, 室谷嘉一, 高島健太, 金澤雅之, 上月正博
  • Journal Title: Therapeutic Research Volume: 30 Pages: 1427-1428
  • Peer Reviewed
• [Presentation] 腎疾患モデルラットにおける長期的運動の効果 (2011)
  • Author(s): 伊藤修
  • Organizer: 第1回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2011-01-07
• [Presentation] 慢性心不全モデルラットの心・腎nitric oxide合成酵素発現への長期的運動の効果 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-15
• [Presentation] Effect of exercise training on renal oxidative stress and renal NO production system in SHR (2010)
  • Author(s): Cao P, Ito O, Ito D, Muroya Y, Guo Q, Ron R, Mori T, Ito S, Kohzuki M
  • Organizer: 23rd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Vancouber
  • Year and Date: 2010-09-27
• [Presentation] Effect of exercise training on nitric oxide synthases in rats with chronic heart failure (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Organizer: 23rd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Vancouber
  • Year and Date: 2010-09-27
• [Presentation] 慢性心不全モデルラットの心・腎nitric oxide合成酵素発現への長期的運動の効果 (2010)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戎栄, 下川宏明, 上月正博
  • Organizer: 第35回日本運動療法学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-07-03
• [Presentation] Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure (2010)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Kohzuki M
  • Organizer: 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-18
• [Presentation] 高血圧自然発症ラットの腎における酸化ストレスとNO産生系への長期的運動の効果 (2010)
  • Author(s): 伊藤修, 曹鵬宇, 伊藤大亮, 室谷嘉一, 郭其, 森建文, 伊藤貞嘉, 上月正博
  • Organizer: 第53回日本腎臓学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] Role of Carbonyl Stress on Renoprotective Effects of Olmesartan and Exercise (2010)
  • Author(s): Jiang Y, Mori T, Guo Q, Ito O, Suda C, Kanazawa M, Kohzuki M, Ito S
  • Organizer: COEX
  • Place of Presentation: Seoul
  • Year and Date: 2010-06-05
• [Presentation] 長期的運動によるnitric oxide合成酵素への影響(その2)-高血圧自然発症ラットとWistar-Kyotoラットの比較 (2010)
  • Author(s): 伊藤修, 伊藤大亮, 須田千尋, 室谷嘉一, 坂田佳子, 森信芳, 長坂誠, 海老原覚, 上月正博
  • Organizer: 第47回日本リハビリテーション医学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-05-21
• [Presentation] Role of Carbonyl Stress on Renoprotective Effects of Olmesartan and Exercise (2010)
  • Author(s): Jiang Y, Mori T, Guo Q, Ito O, Suda C, Kanazawa M, Kohzuki M, Ito S
  • Organizer: ISNnexus
  • Place of Presentation: Kyoto
  • Year and Date: 2010-04-16
• [Presentation] Role of Carbonyl Stress on Renoprotective Effects of Olmesartan and Exercise (2010)
  • Author(s): Jiang Y, Mori T, Guo Q, Ito O, Suda C, Kanazawa M, Kohzuki M, ItoS
  • Organizer: CVEM 2010
  • Place of Presentation: Nara
  • Year and Date: 2010-03-31
• [Presentation] Role of carbonyl stress on renoprotective effects of olmesartan and exercise (2010)
  • Author(s): Guo Q, Mori T, Jiang Y, Ito O, Suda C, Kanazawa M, Kohzuki M, Ito S
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-29
• [Presentation] Combination of chronic exercise, branched-chain amino acid and valsartan enhances renoprotective and peripheral effects in rats with chronic renal failure (2009)
  • Author(s): Yao Q, Kanazawa M, Suda C, Mori N, Ito O, Kohzuki M
  • Organizer: 11th China-Japan Joint Symposium on Hypertension 2009
  • Place of Presentation: Beijing
  • Year and Date: 2009-10-30
• [Presentation] Effects of combination therapy of exercise training and superoxide dismutase mimetic on blood pressure and the nitric oxide synthase in spontaneously hypertensive rats (2009)
  • Author(s): Cao P, Ito O, Guo Q, Chang Y, Ito D, Muroya Y, Takashima K, Kanazawa M, Kohzuki M
  • Organizer: World Hypertension Congress 2009
  • Place of Presentation: Beijing
  • Year and Date: 2009-10-30
• [Presentation] 5/6腎臓摘出慢性腎不全モデルラットの高血圧、インスリン抵抗性、交感神経活性と腎障害に対するcilnidipineと長期的運動の併用効果. (2009)
  • Author(s): 郭其, 金澤雅之, 森建文, 張文博, 須田千尋, 伊藤修, 伊藤貞嘉, 上月正博
  • Organizer: 第32回日本高血圧学会
  • Place of Presentation: 大津
  • Year and Date: 2009-10-03
• [Presentation] 5/6腎臓摘出慢性腎不全モデルラットにおける運動とolmesarutanの腎保護作用に対するカルボニルストレスの役割 (2009)
  • Author(s): 郭其, 森建文, 金澤雅之, 須田千尋, 伊藤修, 宮田敏男, 伊藤貞嘉, 上月正博
  • Organizer: 第32回日本高血圧学会
  • Place of Presentation: 大津
  • Year and Date: 2009-10-03
• [Presentation] 高血圧自然発症ラットのNO合成酵素発現における酸化ストレスの役割 (2009)
  • Author(s): 伊藤修, 曹鵬宇, 郭其, 室谷嘉一, 伊藤大亮, 森建文, 伊藤貞嘉, 上月正博
  • Organizer: 第32回日本高血圧学会
  • Place of Presentation: 大津
  • Year and Date: 2009-10-03
• [Presentation] Disability prevention of chronic renal failure (CRF): Effects of combination therapy with chronic exercise and G-CSF in rats with CRF (2009)
  • Author(s): Suda C, Kanazawa M, Yao Q, Takashima K, Muroya Y, Mori N, Nagasaka M, Ito O, Kurosawa H, Kohzuki M
  • Organizer: 5th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Istanbul
  • Year and Date: 2009-06-15
• [Presentation] Disability prevention of chronic renal failure : Combination of chronic exercise, branched-chain amino acid (BCAA)and valsartan enhances renoprotective and peripheral effects in rats with chronic renal failure. (2009)
  • Author(s): Yao Q, Kanazawa M, Suda C, Ishida A, Mori N, Nagasaka M, Ito O, Kurosawa H, Kohzuki M
  • Organizer: 5th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Istanbul
  • Year and Date: 2009-06-15
• [Presentation] Disability prevention of cardiovascular and chronic kidney diseases : Effects of a combination therapy with exercise training and superoxide dismutase mimetic on blood pressure and nitric oxide synthase in spontaneously hypertensive rats. (2009)
  • Author(s): Cao P, Ito O, Guo Q, Chang Y, Ito D, Muroya Y, Takashima K, Kanazawa M, Kohzuki M
  • Organizer: 5th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Istanbul
  • Year and Date: 2009-06-15
• [Presentation] Disability prevention of cardiovascular and chronic kidney diseases : Effect of a combination therapy with exercise training and atorvastatin on blood pressure and nitric oxide synthase in spontaneously hypertensive rats. (2009)
  • Author(s): Ito D, Ito O, Cao P, Muroya Y, Takashima K, Kanazawa M, Kohzuki M
  • Organizer: 5th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: Istanbul
  • Year and Date: 2009-06-15
• [Presentation] 慢性腎不全ラットにおける長期的運動, bCAAと降圧薬による血圧、腎と骨格筋に対する併用効果 (2009)
  • Author(s): 金澤雅之, 須田千尋, 姚強, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
  • Organizer: 第46回日本リハビリテーション医学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-06-05
• [Presentation] 慢性腎不全ラットにおける長期的運動とG-CSFの併用による運動耐容能と腎への効果 (2009)
  • Author(s): 金澤雅之, 須田千尋, 姚強, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
  • Organizer: 第46回日本リハビリテーション医学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-06-05
• [Presentation] 長期的運動とスタチンの併用効果(その6). 高血圧自然発症ラットへの併用効果 (2009)
  • Author(s): 伊藤修, 伊藤大亮, 室谷嘉一, 森信芳, 長坂誠, 金澤雅之, 上月正博
  • Organizer: 第46回日本リハビリテーション医学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-06-05
• [Presentation] 高血圧自然発症ラットの血圧とNitric Oxide合成酵素に対する長期的運動とatorvastatinの併用の効果 (2009)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 室谷嘉一, 高島健太, 金澤雅之, 上月正博
  • Organizer: 第25回日本リハビリテーション医学会東北地方会
  • Place of Presentation: 山形
  • Year and Date: 2009-02-28
• [Presentation] Effect of exercise training and superoxide dismutase mimetic tempol on blood pressure and the expression of nitric oxide synthase in spontaneously hypertensive rats (2008)
  • Author(s): Cao P, Ito O, Ito D, Muroya Y, Takashima K, Chang Y, Kanazawa M, Kohzuki M
  • Organizer: 10th China-Japan Joint Symposium on Hypertension 2008
  • Place of Presentation: Sapporo
  • Year and Date: 2008-10-21
• [Presentation] 慢性腎不全モデルラットの血圧, 腎、骨格筋におけるバルサルタン、長期的運動、分枝鎖アミノ酸の併用効果. (2008)
  • Author(s): 金澤雅之, 伊藤修, 室谷嘉一, 伊藤大亮, 上月正博
  • Organizer: 第31回日本高血圧学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-20
• [Presentation] 高血圧自然発症ラットの血圧とNO合成酵素に対する長期的運動の影響. (2008)
  • Author(s): 伊藤大亮, 伊藤修, 森信芳, 室谷嘉一, 金澤雅之, 上月正博
  • Organizer: 第31回日本高血圧学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-20
• [Presentation] Effect of combination therapy of chronic exercise, anti-hypertensive drugs on systolic blood pressure, renal function, exercise endurance and skeletal capillaries in a rat model of chronic renal failure (2008)
  • Author(s): Ishida A, Kanazawa M, Lu H, Kawamura T, Ito D, Ito O, Ootaka T, Sato T, Kohzuki M
  • Organizer: 22nd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-15
• [Presentation] Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats (2008)
  • Author(s): Guo Q, Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, Kanazawa M, Kohzuki M
  • Organizer: 22nd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-15
• [Presentation] Combination of chronic exercise and losartan enhances renoprotective and peripheral effects in spontaneously type 2 diabetes mellitus rats with nephropathy (2008)
  • Author(s): Kanazawa M, Tufescu A, Ishida A, Lu H, Ito O, Ootaka T, Sato T, Kohzuki M
  • Organizer: 22nd Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-15
• [Presentation] 2型糖尿病性腎症モデルラットの腎病変, 運動耐容能, 骨格筋毛細血管に及ぼす長期的運動とlosartanの併用効果. (2008)
  • Author(s): 金澤雅之, 須田千尋, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
  • Organizer: 第45回日本リハビリテーション医学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-05
• [Presentation] 慢性腎不全モデルラットにおける長期的運動, bCAAと降圧薬による血圧, 腎と骨格筋に対する併用効果. (2008)
  • Author(s): 金澤雅之, 姚強, 須田千尋, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 上月正博
  • Organizer: 第45回日本リハビリテーション医学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-05
• [Presentation] 慢性腎不全モデルラットにおける長期的運動とG-CSFの併用による腎保護効果. (2008)
  • Author(s): 金澤雅之, 須田千尋, 室谷嘉一, 森信芳, 長坂誠, 伊藤修, 黒澤一, 姚強, 上月正博
  • Organizer: 第45回日本リハビリテーション医学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-05
• [Presentation] 長期的運動による腎nitric oxide合成酵素への影響 (2008)
  • Author(s): 伊藤修, 伊藤大亮, 室谷嘉一, 森信芳, 長坂誠, 金澤雅之, 上月正博
  • Organizer: 高血圧自然発症ラットにおける検討
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-05
• [Book] 腎不全・透析患者のリハビリテーション. 先端医療シリーズ40 :リハ医とコメディカルのための最新リハビリテーション医学 (2010)
  • Author(s): 上月正博, 他
  • Total Pages: 254-257
  • Publisher: 先端医療技術研究所
• [Book] 内部障害のリハビリテーション (2009)
  • Author(s): 上月正博, 他
  • Total Pages: 1-466
  • Publisher: 医歯薬出版