2012 Fiscal Year Final Research Report
Effect of retinal remodeling after photoreceptor degeneration on feasibility of STS-based retinal prosthesis
| Project/Area Number |
20300187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Osaka University |
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Principal Investigator |
SAWAI Hajime 大阪大学, 大学院・医学系研究科, 准教授 (20202103)
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| Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Tomomitsu 大阪大学, 医学系研究科, 助教 (70314309)
YAGI Tetsuya 大阪大学, 工学系研究科, 教授 (50183976)
YAMASHITA Masayuki 奈良県立医科大学, 医学系研究科, 教授 (20183121)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 人工感覚器 |
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| Research Abstract |
The retianl prosthesis is one of the feasible methods to some extent to recover visual sensation of blind patients caused by the degeneration of photoreceptors in the retinas. The feasibility depends on the stabile function of retinal circuitry remaining after photoreceptors degeneration. Since remodeling of the retinal neurons and their networks has been reported, we investigated how electrophysiological and optical response in the retina and visual centers to transretinal electrical stimulation could changed during progress of photoreceptor degeneration in the RCS rat, which is well established as a model animal for patients with retinitis pigmentosa. No significant difference in collicular filed potentials and VSD images of visual cortical response to the stimulation was detected between young and old animals. Retinal cytoarchitecture and dendritic morphology of the retinal ganglion cells after loss of photoreceptors also is well preserved until 36 wks of age. These results suggest that remodeling of retinal circuitry, if any, might not be a seriously taken consideration in development of retinal prosthesis.
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[Journal Article] a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.2008
Author(s)
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T. Pikachurin
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Journal Title
Nat Neurosci.
Volume: Vol.11
Pages: 923-31
Peer Reviewed
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[Journal Article] BIFURCATION-BASED MODEL CONSTRUCTION OF A PYRAMIDAL CELL OF THE PRIMARY VISUAL CORTEX.2008
Author(s)
Ishiki, T., Tanaka, S., Osanai, M., Doi, S., Kumagai, S., Yagi, T.
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Journal Title
INTERNATIONAL JOURNAL OF INNOVATIVE COMPUTING INFORMATION AND CONTROL
Volume: Vol.5
Pages: 831-845
Peer Reviewed
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