2010 Fiscal Year Final Research Report
Mechanism of Tumor formation by deregulated circadian rhythm and strategy for its prevention
| Project/Area Number |
20300229
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
OHTANI Naoko Japanese Foundation For Cancer Research, 癌研究所がん生物部, 主任研究員 (50275195)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生活習慣病 |
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| Research Abstract |
To clarify whether the deregulation of circadian rhythm is involved in cancer, DMBA (7,12-dimethylbenz[a]anthracene) treated mice of 4 or 5 days old were kept in the completely dark condition during day and night (Dark and Dark, DD) or in 12 h-light and 12 h-dark condition (Light and Dark, LD). After 30 weeks, mice were sacrificed, and the spectrum and the number of tumors were analyzed. Mice kept in DD condition developed significantly more lung tumors (3.9 fold more lung tumors in male mice and 2.1 fold more lung tumors in female mice). As a next step, the molecular mechanisms of how deregulation of circadian rhythm promotes lung tumors will be elucidated.
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[Journal Article] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
Author(s)
Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S., Hara E., Ohtani N
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Journal Title
Cancer Research 70
Pages: 9381-9390
Peer Reviewed
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[Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross talk with p53.2009
Author(s)
Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, J. Mann D. J, Ohmura M., Hirao A, Saya H, Arase S, Hayashi Y, Nakao K., Matsumoto M, Ohtani N, Hara E
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Journal Title
J.Cell Biol. 186
Pages: 393-407
Peer Reviewed
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[Presentation] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
Author(s)
Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Ishikawa Y, Sone S, Hara E., Ohtani N
Organizer
Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Aging Cold Spring Harbor
Place of Presentation
New York, USA
Year and Date
2010-09-29
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