Study of food aromatic compound effect to stress and emotion

2010 Fiscal Year Final Research Report

• Project/Area Number: 20300246
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Shizuoka
• Principal Investigator: YOKOGOSHI Hidehiko University of Shizuoka, 食品栄養科学科, 教授 (70109320)
• Project Period (FY): 2008 – 2010
• Keywords: 柑橘香気成分 / 抗ストレス / 情動解析 / 緑の香り / アロマテラピー

Research Abstract

In animal study, the effect of some food chemicals or odor components on neurotransmitters and some kinds of behaviors such as memory-learning ability was examined. In human volunteers, the autonomic nervous system or emotional changes was examined.

Research Products

• [Journal Article] Effects of the quality of dietary amino acids composition on the urea synthesis in rats. (2011)
  • Author(s): Tsujioka, K., Ohsumi M., Hayase K., Yokogoshi H.
  • Journal Title: Journal of Nutritional Science and Vitaminology 57 Pages: 48-55
• [Journal Article] Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acis. (2011)
  • Author(s): Kanehira, T., Nakamura, Y., Nakamura, K., Horie, N., Furugori, K., Sauchi, Y., Yokogoshi H.
  • Journal Title: Journal of Nutritional Science and Vitaminology 57 Pages: 9-15
• [Journal Article] Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. (2011)
  • Author(s): Kobayashi, Y., Kako, H., Yokogoshi H.
  • Journal Title: Cellular and Molecular Neurobiology 30 Pages: 173-184
• [Journal Article] Effect of quality and quantity of dietary protein on 4E-BP1 and S6K1 phosphorylation of brains in aged rats. (2011)
  • Author(s): 大住美穂, 吉澤史昭, 早瀬和利, 横越英彦
  • Journal Title: Journal of Nutritional Science and Vitaminology 56 Pages: 319-325
• [Journal Article] Genistein regulates serotonergic activity in the hippocampus on ovariectomized rats in forced swimming stress. (2011)
  • Author(s): Kageyama, A., Sakakibara, H., Zhou W-J., Yoshioka M., Ohsumi M., Shimoi, K., Yokogoshi H.
  • Journal Title: Bioscience Biotechnology and Biochemistry 74 Pages: 2005-2010
• [Journal Article] 成熟ラットにおける脳4E-BP1並びにS6K1のリン酸化に及ぼす食餌タンパク質の質的、量的影響 (2010)
  • Author(s): 大住美穂、吉澤史昭、早瀬和利、横越英彦
  • Journal Title: 日本栄養・食糧学会誌 63 Pages: 310
• [Journal Article] Effect of quantity and quality of dietary protein on choline acetyltransferase and nerve growth factor, and their mRNAs in the cerebral cortex and hippocampus of rats. (2009)
  • Author(s): Tujioka, K., Shi, X., Ohsumi M., Tuchiya, T., Hayase K., Uchida, T., Ikeda, S., Morishita, A., Yokogoshi H.
  • Journal Title: Amino. Acids 36(1) Pages: 13-9
• [Journal Article] Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. (2009)
  • Author(s): Yamada, T., Terashima, T., Kawano, R., Furuno, R., Okubo, T., Juneja, L.. R., Yokogoshi H.
  • Journal Title: Amino. Acids 36(1) Pages: 21-7
• [Journal Article] Components of lemon essential oil attenuate dementia induced by scopolamine. (2009)
  • Author(s): Zhou W-J., Fukumoto, S., Yokogoshi H.
  • Journal Title: Nutri. Neurosci 12(2) Pages: 57-64
• [Journal Article] Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats. (2009)
  • Author(s): 周文駿, 吉岡みゆき, 横越英彦
  • Journal Title: J.Nutr.Sci. Vitaminol 55 Pages: 367-373
• [Journal Article] Psychological stress-reducing effect of chocolate enriched withγ-aminobutyric acid (GABA) in humans: assessment of stressusing heart rate variability and salivary chromogranin A. (2009)
  • Author(s): Nakamura, H., Takishima, T., Kometani, T., Yokogoshi H.
  • Journal Title: International Journal of Food Sciences and Nutrition 22 Pages: 1-8
• [Journal Article] Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. (2009)
  • Author(s): Kobayashi, Y., Kako, H., Yokogoshi H.
  • Journal Title: Cellular and Molecular Neurobiology
• [Journal Article] 唾液クロモグラニンA濃度測定によるγ-アミノ酪酸とラフマエキスのストレス低減効果の検証 (2009)
  • Author(s): 陽東藍、石原茂正、李楊金緯、Butterrweck, V.、横越英彦
  • Journal Title: 日本生理人類学会誌 14(3) Pages: 55-59
• [Journal Article] Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectmized female rats fed genistein. (2009)
  • Author(s): Lyou, S,, Kawano, S., Yamada, T., Okuyam. S., Terashima, T., Hayase K., Yokogoshi H.
  • Journal Title: J.Nutr. Biochem 20 Pages: 948-955
• [Journal Article] ラットへのs-リモネン投与による脳内神経伝達物質及び行動へのサブ慢性的な影響 (2009)
  • Author(s): 周文駿、吉岡みゆき、横越英彦
  • Journal Title: 日本栄養・食糧学会誌 62(5) Pages: 190
• [Journal Article] ラットへのs-リモネン投与による脳内神経伝達物質及び行動へのサブ慢性的な影響 (2009)
  • Author(s): 周文駿、吉岡みゆき、横越英彦
  • Journal Title: 日本ビタミン学会誌 83(10) Pages: 598
• [Journal Article] Effects of Japanese mistletoe lectin on cytokine gene expression in human colonic carcinoma cells and in the mouse intestine. (2009)
  • Author(s): Monira, P., Koyama, Y., Fukutomi, R., Yasui, K., Isemura, M., Yokogoshi
  • Journal Title: Biomedical Research 30(5) Pages: 303-309
• [Journal Article] Effect of flavor components in lemon essential oil on physical or psychological stress. (2008)
  • Author(s): Fukumoto, S., Morishita, A., Furutachi, K., Terashima, T., Nakayama, T., Yokogoshi H.
  • Journal Title: Stress & Health 24 Pages: 3-12
• [Journal Article] Effects of direct exposure of green odour components on dopamine release from rat brain striatal slices and PC12 cells. (2008)
  • Author(s): Kako, H, Fukumoto, S., Kobayashi, Y., Yokogoshi H.
  • Journal Title: Brain.Res.Bull 75(5) Pages: 706-712
• [Journal Article] Effect of repeated stress in early childhood on the onset of diabetes mellitus in male Spontaneously Diabetic Torii rats. (2008)
  • Author(s): Ookawa, K., Mochizuki, K., Yokogoshi H., Ookawa, K., Mochizuki, K., Yokogoshi H.
  • Journal Title: J.Vet.Med.Sci 70(2) Pages: 145-151
• [Journal Article] The growth hormone affects the brain protein synthesis rate in hypophysectomized aged rats. (2008)
  • Author(s): Ohsumi M., Tujioka, K., Hayase K., Nagata, S., Yokogoshi H.
  • Journal Title: J.Nutr.Sci. Vitaminol 54(1) Pages: 76-81
• [Journal Article] Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test. (2008)
  • Author(s): Yamada, T., Terashima, T., Okubo, T., Juneja, L. R., Yokogoshi H.
  • Journal Title: Biosci. Biotechnol. Biochem 72(5) Pages: 1356-1359
• [Journal Article] Administration of theanine, a unique amino acid in tea leaves, changed feeding-relating components in the serum and feeding behavior in rats. (2008)
  • Author(s): Yamada, T., Nishimura, Y., Sakurai, T., Terashima, T., Okubo, T., Juneja, L. R., Yokogoshi H.
  • Journal Title: Biosci. Biotechnol. Biochem 72(5) Pages: 1352-1355
• [Journal Article] Role of estrogen receptors and aromatase on brain protein synthesis rates in ovariectmized female rats fed genistein. (2008)
  • Author(s): Lyou, S., Kawano, S., Yamada, T., Okuyam, S., Terashima, T., Hayase K., Yokogoshi H.
  • Journal Title: Nutr. Neurosci 1(4) Pages: 155-160
• [Journal Article] Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of brain in mice. (2008)
  • Author(s): Hiratsuka, S., Ishihara K., Kitagawa, T., Wada, S., Yokogoshi. H.
  • Journal Title: J.Nutr.Sci., Vitaminol 54(6) Pages: 501-506
• [Journal Article] Anxiolytic effects of short- and long-term administration of cacao mass on rat elevated T-maze test. (2008)
  • Author(s): Yamada, T., Yamada, Y.,Okano, Y., Terashima, T., Yokogoshi H.
  • Journal Title: Biosci. Biotechnol. Biochem 72(5) Pages: 1352-1355
• [Presentation] 香気成分ヘキサナールによるPC12細胞からのドーパミン放出調節にかかわる因子の解析
• [Presentation] s-Limonene and s-Perillyl Alcohol Attenuated the Dementia Induced by Scopolamine
• [Presentation] Studies of L-Theanine on Nutritional-Physiological Functions. Mechanism of Action and Neurochemistry Theanine and the Brain
• [Presentation] GABA茶の摂取による気分改善効果に関する研究
• [Presentation] みどりの香り成分の直接刺激がラット線条体のドーパミン放出に及ぼす効果.Microdialysis法を用いた解析
• [Presentation] 香気成分ヘキサナールによるドーパミン放出とドーパミン代謝の関連
• [Presentation] 「みどりの香り」投与によるラット脳内神経伝達物質及び記憶学習への影響
• [Presentation] ヘキサナールおよびヘキサノールによって放出される神経伝達物質量の違いと刺激後の代謝調節
• [Presentation] みどりの香りによるラット脳切片からのアミノ酸神経伝達物質放出促進効果
• [Presentation] 脳下垂体摘出成熟ラットにおける脳タンパク質合成速度に及ぼすGABA摂取の影響
• [Presentation] 緑茶テアニンはアミロイド-β-ペプチドの神経毒性から神経細胞死を抑制する
• [Presentation] みどりの香りn-hexanal投与によるラット脳内神経伝達物質量の経時的変動
• [Presentation] PC12細胞へのヘキサナール刺激は130kDaタンパク質の脱リン酸化を促進する
• [Presentation] シアル酸のラット乳幼児期の脳機能に及ぼす影響
• [Presentation] 緑茶中アミノ酸(GABA、テアニン)投与による記憶学習への影響
• [Presentation] Lactobacillus helveticus発酵乳の記憶障害予防及び記憶力向上作用
• [Presentation] 夕方からのストレス負荷によるGABA摂取の影響
• [Presentation] Effects of ML-J on gene expression in human Caco-2 cells and in mouse intestine
• [Presentation] カツオ血合肉のエキス成分が高血圧自然発症ラットの血圧、血清脂質及び脳内神経伝達物質に及ぼす影響
• [Presentation] シアル酸の新機能としての神経科学的解析
• [Presentation] 食薬融合の観点からGABAとハーブの併用による情動に関する研究
• [Presentation] カツオ血合肉エキスの摂取がラット脳の脂質酸化に及ぼす影響
• [Presentation] Effets of a Japanesse mistletoe lectin on cytokine gene expression in human colonic carcinoma cells and in the mouse intestine.
• [Presentation] Effect of n-hexanal, a type of green odor, on brain dopamine release.
• [Presentation] 香気成分n-hexanalによる神経伝達物質放出促進作用とその作用機序に関する研究
• [Presentation] テアニンの機能と利用
• [Presentation] Effect of theanine on young rat's hippocampal neurogenesis and cognitive function.
• [Presentation] Facilitation in hippocampal neurogenesis in young rats fed theanine, an amino acid in tea leaves, and its effect on cognitive function.
• [Presentation] ストレスによる脳内モノアミンの応答と恐怖記憶の関係.
• [Presentation] みどりの香りn-hexanal投与によるラット脳内ドーパミン放出増加とそのメカニズムに関する研究
• [Presentation] ヘキサナール刺激によって脱リン酸化される 130 kDa タンパク質の同定への試み
• [Presentation] ビスフェノールA暴露が行動や脳内モノアミンに与える影響
• [Book] 味と脳の感覚:五感からみた栄養神経科学 食品成分の研究と食品としての機能評価～動物実験からヒトボランティア試験～ (2010)
  • Author(s): 横越英彦
  • Total Pages: 270-274
  • Publisher: 日本食生活学会
• [Book] お砂糖豆知識.甘いおやつの効用 (2010)
  • Author(s): 横越英彦
  • Total Pages: 38-40
  • Publisher: 独立行政法人農畜産業振興機構
• [Book] 食品機能性の科学 (2009)
  • Author(s): 横越英彦
  • Total Pages: 419-423
  • Publisher: 株)産業技術サービスセンター
• [Book] 脳内老化制御とバイオマーカーー基盤研究と食品素材 (2009)
  • Author(s): 横越英彦
  • Total Pages: 191-203
  • Publisher: (株)シーエムシー出版
• [Book] ストレスの科学と健康 (2008)
  • Author(s): 横越英彦
  • Total Pages: 175-179
  • Publisher: 共立出版
• [Book] 紅茶の保健機能と文化 (2008)
  • Author(s): 横越英彦
  • Total Pages: 246-254
  • Publisher: (株)アイ・ケイコーポレーション
• [Book] 食品シリーズ「アミノ酸の科学と最新応用技術」 (2008)
  • Author(s): 横越英彦
  • Total Pages: 246-264
  • Publisher: (株)シーエムシー出版
• [Book] 新材料・新素材シリーズ「竹の基礎科学と高度利用技術」 (2008)
  • Author(s): 横越英彦、他
  • Total Pages: 179-187
  • Publisher: (株)シーエムシー出版
• [Book] 脳と栄養ハンドブック (2008)
  • Author(s): 横越英彦
  • Total Pages: 269-275
  • Publisher: (株)サイエンスフォーラム
• [Book] ネオエスカ「代謝栄養学」 (2008)
  • Author(s): 横越英彦
  • Total Pages: 1-4、159-176、193-202
  • Publisher: 同文書院
• [Remarks] ホームページ等