2011 Fiscal Year Final Research Report
A model for estimation of genetic risk of radiation of human female exposure
| Project/Area Number |
20310033
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation/Chemicals
|
|---|
| Research Institution | 放射線影響研究所 (2011)
Radiation Effects Research Foundation (2008-2010) |
|---|
Principal Investigator |
ASAKAWA Jun-ichi 放射線影響研究所, 遺伝学部, 主任研究員 (10359458)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | 未熟卵母細胞 / DNA2次元電気泳動 / 放射線被ばく / 遺伝リスク |
|---|
| Research Abstract |
We estimated the mutation induction rate by examining DNA samples of 750 F1 rats derived from immature oocytes of dams irradiated with 2.5 Gy of gamma rays and 750 controls by the two-dimensional electrophoresis. There was no increase of deletion mutations in the exposed group. Our data, although still preliminary, imply that the genetic risk of radiation in female immature oocytes is smaller than that in male spermatogonia.
|
