2010 Fiscal Year Final Research Report
INTRODUCTION OF METABONOMICS TO RISK ASSESSMENT OF INSECTICIDES
| Project/Area Number |
20310035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagoya City University (2009-2010)
Nagoya University (2008) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Kenji 名古屋大学, 医学部, 准教授 (80126870)
UEYAMA Jun 名古屋大学, 医学部, 助教 (00397465)
NAKAJIMA Tamie (中島 民江) 名古屋大学, 大学院・医学系研究科, 教授 (10020794)
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| Co-Investigator(Renkei-kenkyūsha) |
ITO Yuki 名古屋市立大学, 大学院・医学研究科, 助教 (80452192)
SHIBATA Eiji 愛知医科大学, 医学部, 教授 (90206128)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 人体有害物質 |
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| Research Abstract |
We developed and established highly sensitive methods of measuring urinary metabolites of organophosphorus and pyrethroid insecticides. The established methods were applied to general population and pesticide sprayers to evaluate their exposure. Furthermore, the relationship between metabolite body burden and male reproductive dysfunction was investigated. It was suggested that evaluation of single insecticide metabolite might lead to underestimation of risk of pesticide exposure.
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[Journal Article] Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats2011
Author(s)
Li Q, Kobayashi M, Inagaki H, Hirata Y, Sato S, Ishizaki M, Okamura A, Dong Wang, Nakajima T, Kamijima M, Kawada T
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Journal Title
Human and Experimental Toxicology
Volume: 30
Pages: 665-74
Peer Reviewed
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[Journal Article] β-Glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure2010
Author(s)
Ueyama J, Satoh T, Kondo T, Takagi K, Shibata E, Goto M, Kimata A, Saito I, Hasegawa T, Wakusawa S, Kamijima M
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Journal Title
Toxicol Lett
Volume: 193
Pages: 115-119
Peer Reviewed
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[Journal Article] Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan2009
Author(s)
Ueyama J, Kimata A, Kamijima M, Hamajima N, Ito Y, Suzuki K, Inoue T, Yamamoto K, Takagi K, Saito I, Miyamoto K, Hasegawa T, Kondo T
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Journal Title
Environ Res
Volume: 109
Pages: 175-80
Peer Reviewed
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[Journal Article] Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers2009
Author(s)
Kimata A, Kondo T, Ueyama J, Yamamoto K, Mochizuki A, Asai K, Takagi K, Okamura A, Wang D, Kamijima M, Nakajima T, Fukaya Y, Shibata E, Gotoh M, Saito I
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Journal Title
J Occup Health
Volume: 51
Pages: 100-5
Peer Reviewed
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[Journal Article] Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms2009
Author(s)
Kimata A, Kondo T, Ueyama J, Yamamoto K, Yoshitake J, Takagi K, Suzuki K, Inoue T, Ito Y, Hamajima N, Kamijima M, Gotoh M, Shibata E
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Journal Title
Int Arch Occup Environ Health
Volume: 82
Pages: 1173-8
Peer Reviewed
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[Journal Article] Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats2008
Author(s)
Ueyama J, Kamijima M, Asai K, Mochizuki A, Wang D, Kondo T, Suzuki T, Takagi K, Kanazawa H, Miyamoto K, Wakusawa S, Hasegawa T
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Journal Title
Toxicol Lett
Volume: 182
Pages: 42-47
Peer Reviewed
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