2010 Fiscal Year Final Research Report
Dynamic Manipulation of Molecules Embedded within Artificial Cell Membrane Supported on Solid Surface
| Project/Area Number |
20310076
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Microdevices/Nanodevices
|
|---|
| Research Institution | NTT Basic Research Laboratories |
|---|
Principal Investigator |
FURUKAWA Kazuaki NTT Basic Research Laboratories, 主任研究員 (40393748)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KASHIMURA Yoshiaki 日本電信電話株式会社NTT物性科学基礎研究所, 研究主任 (90393751)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | マイクロ化学システム / 脂質二分子膜 / 分子操作 |
|---|
| Research Abstract |
In this project, we aimed at establishing the technique for manipulating molecule(s) embedded within a supported lipid bilayer (SLB) using electric field locally applied to the bilayer. The supported lipid bilayer at solid-liquid interface maintains the lateral diffusion characteristics, thus can be regarded as a 2-dimensional molecule system for the embedded molecule(s). We reached to the following two significant achievements. (1) We have successfully formed the gradation of dye-conjugated lipid molecules within SLB using the solid substrate equipping the buried electrodes. This means that the force induced by the electric field overcomes the Brownian motion in the bilayer. (2) We have successfully controlled the self-spreading by switching on and off the voltage supplied to a pair of electrodes with nanogap distance. This means that the trapping force of molecules by an electric field at the nanogap position overcomes the energy for driving self-spreading. By using the nanogap as "molecule gate", we have achieved the dynamic control of the macroscopic structure of self-spreading lipid bilayer.
|
