2010 Fiscal Year Final Research Report
Escherichia coli pan-genome analysis using next-generation DNA sequencing technologies
| Project/Area Number |
20310116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
基礎ゲノム科学
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| Research Institution | University of Miyazaki |
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Principal Investigator |
HAYASHI Tetsuya University of Miyazaki, フロンティア科学実験総合センター, 教授 (10173014)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Yoshitoshi 宮崎大学, フロンティア科学実験総合センター, 助教 (40363585)
OHOKA Tadasuke 宮崎大学, 医学部, 助教 (50363594)
KUROKAWA Ken 東京工業大学, 生命理工学研究科, 教授 (20343246)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ゲノム / 微生物 / 細菌 / 進化 / 感染症 |
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| Research Abstract |
We collected numerous Escherichia coli strains of various pathotypes and origins and performed a large scale genome sequencing using next-generation sequencers. Genomic comparison of these sequenced strains and already sequenced strains provided the pan-genome information of E. coli and revealed several genomic features characteristic to enterohemorrhagic E. coli (EHEC) or other pathotypes. Furthermore, we found a significant number of E. arbertii strains are included in the strains isolated as EHEC or enteropathogenic E. coli (EPEC) and obtained draft sequences of representative E. arbertii strains.
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[Journal Article] The complete genome sequence and comparative genome analysis of enteropathogenic E. coli 0127:H6 strain E2348/69.2009
Author(s)
A.Iguchi, N.R.Thomson, Y.Ogura, D.Saunders, T.Ooka, 他, K.Kurokawa, 他, T.Hayashi, J.Parkhill, G.Frankel
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Journal Title
J.Bacteriol. 191(1)
Pages: 347-354
Peer Reviewed
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