Metabolomics Analysis of Phase Shift and Intercellular Entrainment of Central Circadian Pacemaker Cells

2011 Fiscal Year Final Research Report

• Project/Area Number: 20310119
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 基礎ゲノム科学
• Research Institution: Kanazawa University (2009-2011); Mitsubishi Kagaku Institute of Life Sciences (2008)
• Principal Investigator: TEI Hajime 金沢大学, 自然システム学系, 教授 (00242115)
• Project Period (FY): 2008 – 2011
• Keywords: 概日リズム / 視交叉上核 / 時計遺伝子 / メタボローム / データベース / CE-MS

Research Abstract

This study is focused on the phase shift and inter-cellular entrainment of the cellular circadian rhythms. To clarify the molecule(s) these phenomena, I have constructed a database assembling the results of metabolomic and proteomic analyses. Metabolites involved in the determination of cellular energy states, lipid metabolism, and amino acid biosynthesis worked for the cellular phase shift ; and those involved in xenobiotics and nucleic acid metabolism functioned for cellular entrainment

Research Products

• [Journal Article] Positive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2 (2011)
  • Author(s): Ogawa, Y., Koike, N., Kurosawa, G., Soga, T., Tomita, M., Tei, H.
  • Journal Title: PLoS One Volume: 6 Pages: e18663
  • Peer Reviewed
• [Journal Article] The uterus sustains stable biological clock during pregnancy (2010)
  • Author(s): Akiyama, S., Ohta, H., Watanabe, S., Moriya, T., Hariu, A., Nakahata, N., Chisaka, H., Matsuda, T., Kimura, Y., Tsuchiya, S., Tei, H., Okamura, K., Yaegashi, N.
  • Journal Title: Tohoku J. Exp. Med Volume: 221 Pages: 287-298
  • Peer Reviewed
• [Journal Article] Period-phase map : two-dimensional selection of circadian rhythm-related genes (2009)
  • Author(s): Morioka, R., Arita, M., Sakamoto, K., Kawaguchi, S., Tei, H., Horimoto, K.
  • Journal Title: IET Syst Biol Volume: 3 Pages: 487-495
  • Peer Reviewed
• [Journal Article] Genetic and Molecular Analysis of Wild-Derived Arrhythmic Mice (2009)
  • Author(s): Watanabe, T., Suzuki, T., Ishikawa, A., Yokota, Y., Ueda, H. R., Yamada, R. G., Tei, H., Imai, S., Tomida, S., Kobayashi, J., Naito, E., Yasuo, S., Nakao, N., Namikawa, T., Yoshimura, T., Ebihara, S.
  • Journal Title: PLoS ONE Volume: 4 Pages: e4301
  • Peer Reviewed
• [Journal Article] Ontogeny of circadian organization in the rat (2009)
  • Author(s): Yamazaki, S., Yoshikawa, T., Biscoe, E. W., Numano, R., Gallaspy, L. M., Soulsby, S., Papadimas, E., Pezuk, P., Doyle, S. E., Tei, H., Sakaki, Y., Block, G. D., Menaker, M.
  • Journal Title: J Biol Rhythms Volume: 24 Pages: 55-63
  • Peer Reviewed
• [Journal Article] Maternal feeding controls fetal biological clock (2008)
  • Author(s): Ohta, H., Xu, S., Moriya, T., Iigo, M., Watanabe, T., Nakahata, N., Chisaka, H., Hanita, T., Matsuda, T., Ohura, T., Kimura, Y., Yaegashi, N., Tsuchiya, S., Tei, H., Okamura, K.
  • Journal Title: PLoS ONE Volume: 3 Pages: e2601
  • Peer Reviewed