2011 Fiscal Year Final Research Report
Development of Photosensitizers by using Antenna Molecules-Fullerene Dyad Systems
| Project/Area Number |
20310133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
IKEDA Atsushi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (90274505)
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| Project Period (FY) |
2008 – 2011
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| Keywords | フラーレン / リポソーム / 光線力学治療法 / がん細胞 / 2元系 / エネルギー移動 / 一重項酸素 / 活性酸素 |
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| Research Abstract |
Photodynamic therapy(PDT) is an emerging approach for the treatment of tumour diseases that has received growing interest in the last few years. In this study, we constructed photosynthesis mimetic liposomal photosensitizers(PS) of PDT by shoehorning light-harvesting "antenna" molecules and dense C_<60> into lipid membrane bilayers. The developed liposomal PS showed improved photodynamic activity toward human cancer cells via the photoenergy transfer from photoactivated antenna molecules to C_<60>. This is the first demonstration of photodynamic activity of C_<60> by the irradiation of light matched with the optimal wavelength for PDT(600-700 nm).
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Research Products
(55 results)
