2010 Fiscal Year Final Research Report
Development of designed agents that selectively photo-degrade certain proteins and oligosaccharides
| Project/Area Number |
20310140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
TOSHIMA Kazunobu Keio University, 理工学部, 教授 (60217502)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生物活性分子 / 分子設計 / 合成 / タンパク / 糖 / 光分解 / 細胞 / 分子標的薬 |
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| Research Abstract |
Several agents, that target-selectively photo-degrade certain disease-related proteins and oligosaccharides, were designed and synthesized. Furthermore, it was found the agents thus developed work not only in test tube but also in disease-related cells. From these studies, a new approach for the design of light-activated and molecular-targeted medicines has been established.
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Research Products
(46 results)
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[Presentation]2009
Author(s)
D.Takahashi, S.Tanimoto, S.Sakai, K.Toshima
Organizer
The 25^<th> Naito Conference on Chemical Biology [II]
Place of Presentation
Sapporo
Year and Date
2009-09-09
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