2010 Fiscal Year Final Research Report
Functional association of brain and body underlying decision-making
| Project/Area Number |
20330148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Nagoya University |
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Principal Investigator |
OHIRA Hideki Nagoya University, 環境学研究科, 教授 (90221837)
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| Co-Investigator(Kenkyū-buntansha) |
IIDAKA Tetsuya 名古屋大学, 大学院・医学系研究科, 准教授 (70324366)
ISOWA Tokiko 三重大学, 医学部, 准教授 (30336713)
NOMURA Michio 京都大学, 大学院・教育学研究科, 准教授 (60399011)
NOMURA Shusaku 長岡技術科学大学, 産学融合トップランナー養成センター, 特任准教授 (80362911)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 意思決定 / 感情 / 脳 / 身体 |
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| Research Abstract |
The aim of this study was to elucidate how the brain and body guide optimal decision making though their functional association in uncertain situations. We developed an experimental paradigm called "stochastic learning" where options which were stochastically related to monetary reward and punishment were presented to participants, and they maximized their reward though trials and errors. We examined brain and bodily responses during the task by measuring brain activity by positron emission tomography (PET) and activities of autonomic, endocrine, and immune systems. The main findings were as follows. (1) Bran regions including the prefrontal cortex and striatum were activated during the task and those brain regions regulated bodily responses. (2) Portions of individual differences of emotional responses accompanying reward and punishment were explained by polymorphisms of a serotonin transporter gene. (3) Autonomic activities were represented in the insula cortex. Such bodily representation in the brain could determine randomness of decision making. (4) These functional associations of brain and body accompanying decision making were blunted by chronic stress.
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[Journal Article] Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men.
Author(s)
Ohira H, Matsunaga M, Isowa T, Nomura M, Ichikawa N, Kimura K, Kanayama N, Murakami H, Osumi T, Konagaya T, Nogimori T, Fukuyama S, Shinoda J, Yamada J.
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Journal Title
Peer Reviewed
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